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1. Organization and Significant Accounting Policies - Potentially dilutive securities (Details) - shares
12 Months Ended
Dec. 31, 2015
Dec. 31, 2014
Basic and diluted weighted average common stock shares outstanding 12,177,396 10,447,030
Common stock options    
Potentially dilutive securities excluded from loss per share computations:    
Shares 2,555,263 1,390,770
Warrants    
Potentially dilutive securities excluded from loss per share computations:    
Shares 7,195,997 7,428,141