-----BEGIN PRIVACY-ENHANCED MESSAGE-----
Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
Originator-Key-Asymmetric:
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 TWSM7vrzLADbmYQaionwg5sDW3P6oaM5D3tdezXMm7z1T+B+twIDAQAB
MIC-Info: RSA-MD5,RSA,
 Ve5DTcH2y6neO7cSA5WgWHE66eAOp32Yq4rusW4G4/wMViVt2wKaT0TSpmK/mlhl
 fzUMF2OQmTae+be/9KiNqQ==

<SEC-DOCUMENT>0001241181-04-000001.txt : 20040116
<SEC-HEADER>0001241181-04-000001.hdr.sgml : 20040116
<ACCEPTANCE-DATETIME>20040116151338
ACCESSION NUMBER:		0001241181-04-000001
CONFORMED SUBMISSION TYPE:	4
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20040113
FILED AS OF DATE:		20040116

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			DE GREEF RODERICK
		CENTRAL INDEX KEY:			0001241181

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-18170
		FILM NUMBER:		04529627

	BUSINESS ADDRESS:	
		STREET 1:		1900 MAIN ST
		STREET 2:		STE 700
		CITY:			IRVINE
		STATE:			CA
		ZIP:			92614
		BUSINESS PHONE:		9497973800

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			BIOLIFE SOLUTIONS INC
		CENTRAL INDEX KEY:			0000834365
		STANDARD INDUSTRIAL CLASSIFICATION:	ELECTROMEDICAL & ELECTROTHERAPEUTIC APPARATUS [3845]
		IRS NUMBER:				943076866
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		SUNY PARK SCIENCE III
		STREET 2:		SUITE 144
		CITY:			BINGHAMTON
		STATE:			NY
		ZIP:			13902-6000
		BUSINESS PHONE:		6077772775

	MAIL ADDRESS:	
		STREET 1:		SUNYPARK SCIENCE III
		STREET 2:		STE 144
		CITY:			BINGHAMTON
		STATE:			NY
		ZIP:			13902-6000

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	BIOLIFE SOLUTION INC
		DATE OF NAME CHANGE:	20030113

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	CRYOMEDICAL SCIENCES INC
		DATE OF NAME CHANGE:	19920703
</SEC-HEADER>
<DOCUMENT>
<TYPE>4
<SEQUENCE>1
<FILENAME>edgar.xml
<DESCRIPTION>PRIMARY DOCUMENT
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>
    <schemaVersion>X0201</schemaVersion>

    <documentType>4</documentType><periodOfReport>2004-01-13</periodOfReport>
    <issuer>
        <issuerCik>0000834365</issuerCik>
        <issuerName>BIOLIFE SOLUTIONS INC</issuerName>
        <issuerTradingSymbol>BLFS</issuerTradingSymbol></issuer><reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001241181</rptOwnerCik>
            <rptOwnerName>DE GREEF RODERICK</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O CARDIAC SCIENCE</rptOwnerStreet1>
            <rptOwnerStreet2>1900 MAIN STREET, SUITE 700</rptOwnerStreet2>
            <rptOwnerCity>IRVINE</rptOwnerCity>
            <rptOwnerState>CA</rptOwnerState>
            <rptOwnerZipCode>92614</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
            <reportingOwnerRelationship>
<isDirector>1</isDirector><isOfficer>0</isOfficer><isTenPercentOwner>0</isTenPercentOwner><isOther>0</isOther></reportingOwnerRelationship></reportingOwner><derivativeTable><derivativeTransaction><securityTitle><value>Series G Convertible Preferred Stock</value></securityTitle><conversionOrExercisePrice><footnoteId id="F2"/></conversionOrExercisePrice><transactionDate><value>2004-01-13</value></transactionDate><transactionCoding><transactionFormType>4</transactionFormType><transactionCode>P</transactionCode><equitySwapInvolved>0</equitySwapInvolved></transactionCoding><transactionAmounts><transactionShares><value>4</value></transactionShares><transactionPricePerShare><footnoteId id="F1"/></transactionPricePerShare><transactionAcquiredDisposedCode><value>A</value></transactionAcquiredDisposedCode></transactionAmounts><exerciseDate><footnoteId id="F3"/></exerciseDate><expirationDate><footnoteId id="F4"/></expirationDate><underlyingSecurity><underlyingSecurityTitle><value>Common Stock</value></underlyingSecurit
yTitle><underlyingSecurityShares><value>1250000</value></underlyingSecurityShares></underlyingSecurity><postTransactionAmounts><sharesOwnedFollowingTransaction><value>4</value></sharesOwnedFollowingTransaction></postTransactionAmounts><ownershipNature><directOrIndirectOwnership><value>D</value></directOrIndirectOwnership><natureOfOwnership><value/></natureOfOwnership></ownershipNature></derivativeTransaction><derivativeTransaction><securityTitle><value>Common Stock Warrants (right to buy)</value></securityTitle><conversionOrExercisePrice><value>.08</value></conversionOrExercisePrice><transactionDate><value>2004-01-13</value></transactionDate><transactionCoding><transactionFormType>4</transactionFormType><transactionCode>P</transactionCode><equitySwapInvolved>0</equitySwapInvolved></transactionCoding><transactionAmounts><transactionShares><value>4</value></transactionShares><transactionPricePerShare><footnoteId id="F1"/></transactionPricePerShare><transactionAcquiredDisposedCode><value>A</value></transactionA
cquiredDisposedCode></transactionAmounts><exerciseDate><footnoteId id="F3"/></exerciseDate><expirationDate><value>2013-10-31</value></expirationDate><underlyingSecurity><underlyingSecurityTitle><value>Common Stock</value></underlyingSecurityTitle><underlyingSecurityShares><value>1250000</value></underlyingSecurityShares></underlyingSecurity><postTransactionAmounts><sharesOwnedFollowingTransaction><value>4</value></sharesOwnedFollowingTransaction></postTransactionAmounts><ownershipNature><directOrIndirectOwnership><value>D</value></directOrIndirectOwnership><natureOfOwnership><value/></natureOfOwnership></ownershipNature></derivativeTransaction></derivativeTable><footnotes><footnote id="F1">The reported securities are included within 4 BioLife Solutions, Inc. Units purchased by the reporting person for $25,000.00 per Unit.  Each Unit consists of one share of Series G Convertible Preferred Stock convertible into 312,500 shares of common stock per share, and one warrant to purchase 312,500 shares of common stoc
k at a price of $0.08 per share.</footnote><footnote id="F2">1 for 312,500</footnote><footnote id="F3">Immediately</footnote><footnote id="F4">Such Preferred Stock is perpetual.</footnote></footnotes><remarks/><ownerSignature><signatureName>Roderick de Greef</signatureName><signatureDate>2004-01-13</signatureDate></ownerSignature></ownershipDocument>

</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
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