-----BEGIN PRIVACY-ENHANCED MESSAGE-----
Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
Originator-Key-Asymmetric:
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 TWSM7vrzLADbmYQaionwg5sDW3P6oaM5D3tdezXMm7z1T+B+twIDAQAB
MIC-Info: RSA-MD5,RSA,
 VDCzde0UxL/21VO8BKWavHatyjznl/TqiJgU9mMftMbzYiuzLFG49QYZRVioetTL
 XfQtGcPHMFzzuwi1rs0yGg==

<SEC-DOCUMENT>0001238931-05-000001.txt : 20050617
<SEC-HEADER>0001238931-05-000001.hdr.sgml : 20050617
<ACCEPTANCE-DATETIME>20050617184859
ACCESSION NUMBER:		0001238931-05-000001
CONFORMED SUBMISSION TYPE:	4
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20050617
FILED AS OF DATE:		20050617
DATE AS OF CHANGE:		20050617

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			KING GARY
		CENTRAL INDEX KEY:			0001238931

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-21873
		FILM NUMBER:		05904183

	BUSINESS ADDRESS:	
		STREET 1:		C/O BIOSITE INC
		STREET 2:		11030 ROSELLE STREET
		CITY:			SAN DIEGO
		STATE:			CA
		ZIP:			92121
		BUSINESS PHONE:		8584554808

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			BIOSITE INC
		CENTRAL INDEX KEY:			0000834306
		STANDARD INDUSTRIAL CLASSIFICATION:	IN VITRO & IN VIVO DIAGNOSTIC SUBSTANCES [2835]
		IRS NUMBER:				330288606
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		11030 ROSELLE ST
		CITY:			SAN DIEGO
		STATE:			CA
		ZIP:			92121
		BUSINESS PHONE:		6194554808

	MAIL ADDRESS:	
		STREET 1:		11030 ROSELLE ST
		CITY:			SAN DIEGO
		STATE:			CA
		ZIP:			92121

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	BIOSITE DIAGNOSTICS INC
		DATE OF NAME CHANGE:	19960710
</SEC-HEADER>
<DOCUMENT>
<TYPE>4
<SEQUENCE>1
<FILENAME>edgardoc.xml
<DESCRIPTION>PRIMARY DOCUMENT
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0202</schemaVersion>

    <documentType>4</documentType>

    <periodOfReport>2005-06-17</periodOfReport>

    <notSubjectToSection16>0</notSubjectToSection16>

    <issuer>
        <issuerCik>0000834306</issuerCik>
        <issuerName>BIOSITE INC</issuerName>
        <issuerTradingSymbol>BSTE</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001238931</rptOwnerCik>
            <rptOwnerName>KING GARY</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>BIOSITE INCORPORATED</rptOwnerStreet1>
            <rptOwnerStreet2>11030 ROSELLE STREET</rptOwnerStreet2>
            <rptOwnerCity>SAN DIEGO</rptOwnerCity>
            <rptOwnerState>CA</rptOwnerState>
            <rptOwnerZipCode>92121</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>1</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>1</isOther>
            <officerTitle>VP International Sales</officerTitle>
            <otherText>VP International Sales</otherText>
        </reportingOwnerRelationship>
    </reportingOwner>

    <derivativeTable>
        <derivativeTransaction>
            <securityTitle>
                <value>Non-Qualified Stock Option (right to buy)</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <value>53.38</value>
            </conversionOrExercisePrice>
            <transactionDate>
                <value>2005-06-17</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>A</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>15000</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>0</value>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>A</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <exerciseDate>
                <footnoteId id="F1"/>
            </exerciseDate>
            <expirationDate>
                <value>2015-06-17</value>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>15000</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>15000</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </derivativeTransaction>
    </derivativeTable>

    <footnotes>
        <footnote id="F1">Option vests in sixteen equal quarterly installments over four years (on each quarterly anniversary of the applicable vesting commencement date), provided that no shares may be exercised during the first six (6) month period following the commencement of vesting.</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>By: Robyn Shutak  For: Gary King</signatureName>
        <signatureDate>2005-06-17</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
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