Note 8 - Income Taxes (Tables)

12 Months Ended

Dec. 31, 2022

Notes Tables

Schedule of Deferred Tax Assets and Liabilities [Table Text Block]

	2022			2021
Deferred tax assets:
Net operating loss carryforward	$	19,764,569		$	18,449,694
Research and development tax credit carryforward		2,202,603			1,566,293
Stock-based compensation expense		330,553			129,475
Accrued expenses		663,211			69,940
Total deferred tax assets		22,960,936			20,215,402
Deferred tax liabilities
Depreciation		51,466			30,945
Net deferred tax assets		22,909,470			20,184,457
Valuation allowance		(22,909,470	)		(20,184,457	)
Net deferred tax asset after reduction for valuation allowance	$	-0-		$	-0-

Schedule of Effective Income Tax Rate Reconciliation [Table Text Block]

	2022			2021
U.S. federal statutory rate applied to pretax loss		21.0	%		21.0	%
State income tax (benefit)		3.9			4.0
Permanent differences		(0.0	)		0.2
NOL carryforward expiration		(15.6	)		(5.3	)
R&D tax credits, net of expiration		4.6			2.0
Change in valuation allowance and other adjustments		(13.9	)		(21.9	)
Effective tax rate		0.0	%		0.0	%