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Note 8 - Income Taxes - Reconciliation of Income Tax Benefit (Details)
12 Months Ended
Dec. 31, 2022
Dec. 31, 2021
U.S. federal statutory rate applied to pretax loss 21.00% 21.00%
State income tax (benefit) 3.90% 4.00%
Permanent differences (0.00%) 0.20%
NOL carryforward expiration (15.60%) (5.30%)
R&D tax credits, net of expiration 4.60% 2.00%
Change in valuation allowance and other adjustments (13.90%) (21.90%)
Effective tax rate 0.00% 0.00%