Note 6 - Stock-based Compensation Expense (Tables)

12 Months Ended

Dec. 31, 2022

Notes Tables

Schedule of Share-Based Payment Award, Stock Options, Valuation Assumptions [Table Text Block]

	2022			2021
Weighted average risk-free interest rates		3.54	%		1.43	%
Expected dividend yield		0.0	%		0.0	%
Expected life of option (in yrs)		7.0			7.0
Expected volatility		160.0	%		84.8	%

Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Table Text Block]

	2022		2021
Stock options:
Research and development	$	225,031	$	96,814
General and administrative		548,346		172,613
Total stock option expense		773,377		269,427
Stock awards (consultants):
General and administrative		128,697		100,560
Total stock-based compensation expense	$	902,074	$	369,987