Note 9 - Income Taxes (Tables)

12 Months Ended

Dec. 31, 2021

Notes Tables

Schedule of Deferred Tax Assets and Liabilities [Table Text Block]

	2021			2020
Deferred tax assets:
Net operating loss carryforward	$	18,449,694		$	14,737,240
Research and development tax credit carryforward		1,566,293			1,189,110
Stock-based compensation expense		129,475			4,870
Accrued salaries		69,940			72,721
Total deferred tax assets		20,215,402			16,003,941
Deferred tax liabilities
Depreciation		30,945			28,274
Net deferred tax assets		20,184,457			15,975,667
Valuation allowance		(20,184,457	)		(15,975,667	)
Net deferred tax asset after reduction for valuation allowance	$	-0-		$	-0-

Schedule of Effective Income Tax Rate Reconciliation [Table Text Block]

	2021			2020
U.S. federal statutory rate applied to pretax loss	$	(3,899,767	)	$	(621,194	)
Permanent differences		-			65
Research and development credits		(377,183	)		(66,574	)
Change in valuation allowance, net of expired items and other adjustments		4,276,950			687,703
Reported income tax expense	$	-0-		$	-0-