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Note 5 - Property and Equipment (Tables)
 6 Months Ended
Jun. 30, 2019
Notes Tables  
Property, Plant and Equipment [Table Text Block]
   
June 30,
2019
    
December 31,
2018
  
Laboratory equipment
   $
534,578
     $
530,306
  
Leasehold improvements
    
115,605
      
115,605
  
Other furniture, fixtures & equipment
    
28,685
      
28,685
  
Total property and equipment
    
678,868
      
674,596
  
Accumulated depreciation and amortization
    
(667,041
 )    
(663,246
 )
Property and equipment, net
   $
11,827
     $
11,350