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Note 5 - Property and Equipment (Tables)
3 Months Ended
Mar. 31, 2019
Notes Tables  
Property, Plant and Equipment [Table Text Block]
   
March 31,
2019
   
December 31,
2018
 
Laboratory equipment
  $
534,578
    $
530,306
 
Leasehold improvements
   
115,605
     
115,605
 
Other furniture, fixtures & equipment
   
28,685
     
28,685
 
Total property and equipment
   
678,868
     
674,596
 
Accumulated depreciation and amortization
   
(665,143
)    
(663,246
)
Property and equipment, net
  $
13,725
    $
11,350