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Note 8 - Stockholders' Equity (Details Textual) - USD ($)
1 Months Ended 3 Months Ended 12 Months Ended
Mar. 31, 2017
Oct. 31, 2014
Mar. 31, 2017
Mar. 31, 2016
Dec. 31, 2016
Dec. 31, 2015
Dec. 31, 2014
Stock Issued During Period, Shares, Warrants Exercised 983,334            
Proceeds from Warrant Exercises $ 49,167            
General and Administrative Expense     $ 292,667 $ 906,505 $ 2,131,426 $ 1,429,731 $ 1,807,605
Expense Associated with Warrant Modifications [Member]              
Stock Issued During Period, Shares, Warrants Exercised   3,176,000     21,884,420    
Proceeds from Warrant Exercises   $ 873,400     $ 1,339,801    
General and Administrative Expense       469,799 912,862 0 277,912
2006 Equity Incentive Plan [Member]              
Allocated Share-based Compensation Expense     14,580 $ 13,686 54,805 $ 67,905 $ 101,191
Employee Service Share-based Compensation, Nonvested Awards, Compensation Cost Not yet Recognized $ 117,404   $ 117,404   $ 132,032    
Employee Service Share-based Compensation, Nonvested Awards, Compensation Cost Not yet Recognized, Period for Recognition     2 years 109 days   2 years 182 days