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Condensed Consolidated Statements of Cash Flows (Unaudited) - USD ($)
3 Months Ended 12 Months Ended
Mar. 31, 2017
Mar. 31, 2016
Dec. 31, 2016
Dec. 31, 2015
Dec. 31, 2014
Cash flows from operating activities:          
Net loss $ (548,341) $ (1,296,279) $ (3,271,701) $ (2,689,287) $ (2,733,555)
Adjustments to reconcile net loss to net cash used in operating activities:          
Depreciation and amortization 6,898 7,195 28,780 28,935 69,037
Stock-based compensation expense 14,580 483,485 967,667 67,905 479,103
Changes in assets and liabilities:          
Grant funds receivable 6,560 119,978 91,904 (40,637) 61,568
Prepaid expenses and other current assets 10,151 17,102 (5,626) (12,146) (934)
Accounts payable and accrued expenses 178,054 39,455 242,857 (60,033) (125,326)
Total adjustments 216,243 667,215 1,325,582 (15,976) 483,448
Net cash used in operating activities (332,098) (629,064) (1,946,119) (2,705,263) (2,250,107)
Cash flows from investing activities:          
Purchase of property and equipment (4,350) (15,850) (35,503)
Net cash used in investing activities (4,350) (15,850) (35,503)
Cash flows from financing activities:          
Proceeds from sale of common stock 49,167 238,198 1,339,801 873,400
Net cash provided by financing activities 49,167 238,198 1,339,801 2,679,810 873,400
Net decrease in cash and cash equivalents (287,281) (390,866) (606,318) (41,303) (1,412,210)
Cash and cash equivalents at beginning of period 454,030 1,060,348 1,060,348 1,101,651 2,513,861
Cash and cash equivalents at end of period $ 166,749 $ 669,482 $ 454,030 $ 1,060,348 $ 1,101,651