EXHIBIT 32.1
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                CERTIFICATION PURSUANT TO 18 U.S.C. SECTION 1350,
                       AS ADOPTED PURSUANT TO SECTION 906
                        OF THE SARBANES-OXLEY ACT OF 2002


In connection with the Quarterly Report of Semotus Solutions, Inc. (the
"Company") on Form 10-QSB for the period ended September 30, 2006 as filed with
the Securities and Exchange Commission on the date hereof (the "Form 10-QSB"),
I, Anthony N. LaPine, Chief Executive Officer of the Company, certify, pursuant
to 18 U.S.C. ss.1350, as adopted pursuant to ss.906 of the Sarbanes-Oxley Act of
2002, that:


(1)  The Form 10-QSB fully complies with the requirements of Section 13(a) or
     15(d) of the Securities Exchange Act of 1934 (15 U.S.C. 78m or 78o(d)); and


(2)  The information contained in the Form 10-QSB fairly presents, in all
     material respects, the financial condition and results of operations of the
     Company.



DATED: NOVEMBER 8, 2006                   /S/ ANTHONY N. LAPINE
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                                          ANTHONY N. LAPINE
                                          CHIEF EXECUTIVE OFFICER