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Condensed Consolidated Statements of Cash Flows - USD ($)
$ in Thousands
3 Months Ended
Mar. 31, 2022
Mar. 31, 2021
Cash Flows From Operating Activities:    
Loss from continuing operations $ (15,402) $ (35,676)
Loss from discontinued operations, net of income taxes (40) (21)
Net loss (15,442) (35,697)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation and amortization 73 65
Stock-based compensation 3,011 4,212
Non-cash lease expense 358 401
Other non-cash items 462 68
Loss on disposal of assets 3 0
Realized gain on sale of equity holdings (645) (2,856)
Unrealized loss on equity holdings 1,538 4,999
Changes in operating assets and liabilities:    
Other receivables 387 (324)
Prepaid expenses and other current assets (1,051) 670
Other assets 288 (36)
Accounts payable and other accrued liabilities (9,944) (1,681)
Accrued payroll and benefits (5,338) (4,408)
Other long-term liabilities (3,996) 96
Net cash used in operating activities (30,296) (34,491)
Cash Flows From Investing Activities:    
Proceeds from maturities of investments 805 49,823
Proceeds from sale of equity holdings 287 2,858
Purchases of investments (625) (15,964)
Purchases of property and equipment, net (39) (73)
Net cash provided by investing activities 428 36,644
Cash Flows From Financing Activities:    
Issuance of common shares to Hanmi Pharmaceutical Co., Ltd. 20,000 0
Proceeds from sale of common stock under an at-the-market sales agreement, net 0 21,357
Net cash provided by financing activities 20,000 21,357
Effect of exchange rates on cash and cash equivalents 8 2
Net (decrease) increase in cash and cash equivalents (9,860) 23,512
Cash and cash equivalents—beginning of period 88,539 46,009
Cash and cash equivalents—end of period 78,679 69,521
Supplemental disclosure of cash flow information:    
Cash paid for facility and equipment under operating leases 584 620
Cash paid for income taxes 0 4
Noncash investing activities:    
Additions of property and equipment that remain in accounts payable and other accrued liabilities $ 0 $ 27