Consolidated Statements of Stockholders' Equity - USD ($) $ in Thousands	Total	Preferred Stock [Member]	Common Stock [Member]	Common Stock [Member] Hanmi [Member]	Common Stock [Member] NDDO [Member]	Additional Paid-In Capital [Member]	Additional Paid-In Capital [Member] Hanmi [Member]	Additional Paid-In Capital [Member] NDDO [Member]	Accumulated Other Comprehensive Income (Loss) [Member]	Accumulated Deficit [Member]	Treasury Stock [Member]	Total Stockholders Equity [Member]	Total Stockholders Equity [Member] Hanmi [Member]	Total Stockholders Equity [Member] NDDO [Member]	Conversion Hedge [Member] Common Stock [Member]	Conversion Hedge [Member] Additional Paid-In Capital [Member]	Conversion Hedge [Member] Total Stockholders Equity [Member]	Preferred Stock to Common Stock [Member] Preferred Stock [Member]	Preferred Stock to Common Stock [Member] Common Stock [Member]	Preferred Stock to Common Stock [Member] Additional Paid-In Capital [Member]	Preferred Stock to Common Stock [Member] Total Stockholders Equity [Member]
Beginning Balance at Dec. 31, 2014		$ 123	$ 66			$ 543,656			$ (850)	$ (288,441)	$ 0	$ 254,554
Beginning Balance, (shares) at Dec. 31, 2014		20	65,969,699								0
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Net income (loss)	$ (52,642)									(52,642)		(52,642)
Other comprehensive income (loss), net	$ (4,469)								(4,469)			(4,469)
Issuance of common stock to 401(k) plan						1,124						1,124
Issuance of common stock to 401(k) plan, (shares)			179,865
Issuance of common stock for ESPP						627						627
Issuance of common stock for ESPP, (shares)			114,578
Issuance of common stock upon exercise of stock options						1,482						1,482
Issuance of common stock upon exercise of stock options, (shares)	456,082		456,082
Warrant modification						568						568
RSA and stock option issuances and forfeitures for terminations, net			$ 2			12,249						12,251
RSA and stock option issuances and forfeitures for terminations, net, (shares)			1,613,553
Repurchase/retirement of RSAs to satisfy employee tax withholding						(638)						(638)
Repurchase/retirement of RSAs to satisfy employee tax withholding (shares)			(104,842)
Issuance of common stock for milestone achievement			$ 0			0						0
Issuance of common stock for milestone achievement, (shares)			0
Ending Balance at Dec. 31, 2015		$ 123	$ 68			559,068			(5,319)	(341,083)	$ 0	212,857
Ending Balance, (shares) at Dec. 31, 2015		20	68,228,935								0
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Net income (loss)	$ (69,770)									(69,770)		(69,770)
Other comprehensive income (loss), net	$ 3,740								3,740			3,740
Issuance of common stock to 401(k) plan						953						953
Issuance of common stock to 401(k) plan, (shares)			172,650
Issuance of common stock for ESPP						668						668
Issuance of common stock for ESPP, (shares)			150,303
Issuance of common stock upon exercise of stock options						202						202
Issuance of common stock upon exercise of stock options, (shares)	39,010		39,010
RSA and stock option issuances and forfeitures for terminations, net			$ 1			12,717						12,718
RSA and stock option issuances and forfeitures for terminations, net, (shares)			868,032
Repurchase/retirement of RSAs to satisfy employee tax withholding						(1,397)						(1,397)
Repurchase/retirement of RSAs to satisfy employee tax withholding (shares)			(266,860)
Common stock issued under an at-market-issuance sales agreement (Note 7)			$ 11			73,858						73,869
Common stock issued under an at market issuance sales agreement (Note 7), (shares)	10,890,915		10,890,915
Issuance of common stock for milestone achievement							$ 2,308	$ 111					$ 2,308	$ 111
Issuance of common stock for milestone achievement, (shares)				318,750	25,000
Conversion of preferred shares into common stock (Note 7)																$ (227)	$ (227)	$ (123)	$ 0	$ 123	$ 0
Conversion of preferred shares into common stock (Note 7), (shares)																		(20)	40,000
Dividend paid on preferred shares (Note 7)										(6)		(6)
Ending Balance at Dec. 31, 2016	$ 236,026	$ 0	$ 80			648,384			(1,579)	(410,859)	$ 0	236,026
Ending Balance, (shares) at Dec. 31, 2016	80,466,735	0	80,466,735								0
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Net income (loss)	$ (91,248)									(91,248)		(91,248)
Other comprehensive income (loss), net	$ 17,578								17,578			17,578
Issuance of common stock to 401(k) plan						912						912
Issuance of common stock to 401(k) plan, (shares)			102,874
Issuance of common stock for ESPP						1,010						1,010
Issuance of common stock for ESPP, (shares)			203,229
Issuance of common stock upon exercise of stock options			$ 1			5,477						5,478
Issuance of common stock upon exercise of stock options, (shares)	937,482		864,897
RSA and stock option issuances and forfeitures for terminations, net						13,197						13,197
RSA and stock option issuances and forfeitures for terminations, net, (shares)			548,394
Repurchase/retirement of RSAs to satisfy employee tax withholding						(4,331)						(4,331)
Repurchase/retirement of RSAs to satisfy employee tax withholding (shares)			(373,822)
Issuance of common stock upon vesting of RSUs	$ 1,030					1,030
Common stock issued under an at-market-issuance sales agreement (Note 7)			$ 14			128,258						128,272
Common stock issued under an at market issuance sales agreement (Note 7), (shares)			13,558,132
Conversion of preferred shares into common stock (Note 7)															$ 5	$ 43,410	$ 43,415
Conversion of preferred shares into common stock (Note 7), (shares)															5,372,296
Ending Balance at Dec. 31, 2017	$ 351,339	$ 0	$ 100			$ 837,347			$ 15,999	$ (502,107)	$ 0	$ 351,339
Ending Balance, (shares) at Dec. 31, 2017	100,742,735	0	100,742,735								0