Consolidated Statements of Operations - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2017	Dec. 31, 2016	Dec. 31, 2015
Revenues:
Product sales, net	$ 116,178	$ 128,596	$ 136,851
License fees and service revenue	12,189	17,848	25,705
Total revenues	128,367	146,444	162,556
Operating costs and expenses:
Cost of sales (excludes amortization and impairment charges of intangible assets)	42,859	27,953	27,689
Cost of service revenue	4,359	7,890	0
Selling, general and administrative	84,267	88,418	88,064
Research and development	65,895	59,123	51,073
Amortization and impairment charges of intangible assets	27,647	25,946	38,319
Total operating costs and expenses	225,027	209,330	205,145
Loss from operations	(96,660)	(62,886)	(42,589)
Other (expense) income:
Interest expense, net	(6,798)	(9,435)	(9,074)
Change in fair value of contingent consideration related to acquisitions	(4,957)	(649)	676
Other (expense) income, net	389	887	(1,249)
Total other expenses	(11,366)	(9,197)	(9,647)
Loss before income taxes	(108,026)	(72,083)	(52,236)
Benefit (provision) for income taxes	16,778	2,313	(406)
Net loss	$ (91,248)	$ (69,770)	$ (52,642)
Net loss per share:
Basic ($ per share)	$ (1.07)	$ (0.96)	$ (0.81)
Diluted ($ per share)	$ (1.07)	$ (0.96)	$ (0.81)
Weighted average shares outstanding:
Basic (shares)	85,115,592	72,824,070	64,882,417
Diluted (shares)	85,115,592	72,824,070	64,882,417