Consolidated Statements of Stockholders' Equity - USD ($) $ in Thousands	Total	Preferred Stock [Member]	Common Stock [Member]	Additional Paid-In Capital [Member]	Accumulated Other Comprehensive Income (Loss) [Member]	Accumulated Deficit [Member]	Treasury Stock [Member]	Total Stockholders Equity [Member]	Hanmi [Member] Common Stock [Member]	Hanmi [Member] Additional Paid-In Capital [Member]	Hanmi [Member] Total Stockholders Equity [Member]	NDDO [Member] Common Stock [Member]	NDDO [Member] Additional Paid-In Capital [Member]	NDDO [Member] Total Stockholders Equity [Member]
Beginning Balance at Dec. 31, 2013		$ 123	$ 64	$ 518,144	$ 894	$ (237,619)	$ 0	$ 281,606
Beginning Balance, Shares at Dec. 31, 2013		20	64,104,173				0
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Net income (loss)	$ (45,719)					(45,719)		(45,719)
Other comprehensive income (loss), net	$ (1,744)				(1,744)			(1,744)
Issuance of common stock to 401(k) plan				1,028				1,028
Issuance of common stock to 401(k) plan, Shares			133,734
Issuance of common stock for ESPP				639				639
Issuance of common stock for ESPP, Shares			99,551
Issuance of common stock upon exercise of stock options			$ 1	1,905				1,906
Issuance of common stock upon exercise of stock options, Shares	485,260		485,260
RSA issuances and forfeitures for terminations, net				10,781				10,781
RSA issuances and forfeitures for terminations, net, Shares			396,083
Purchase/retirement of RSAs to satisfy employee tax withholding				(1,733)				(1,733)
Repurchase of shares to satisfy employee tax withholding, Shares			(249,102)
Issuance of common stock for milestone achievement			$ 1	7,789				7,790
Issuance of common stock for milestone achievement, Shares			1,000,000
Ending Balance at Dec. 31, 2014		$ 123	$ 66	538,553	(850)	(283,338)	$ 0	254,554
Ending Balance, Shares at Dec. 31, 2014		20	65,969,699				0
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Net income (loss)	$ (50,785)					(50,785)		(50,785)
Other comprehensive income (loss), net	$ (4,469)				(4,469)			(4,469)
Issuance of common stock to 401(k) plan				1,124				1,124
Issuance of common stock to 401(k) plan, Shares			179,865
Issuance of common stock for ESPP				627				627
Issuance of common stock for ESPP, Shares			114,578
Issuance of common stock upon exercise of stock options			$ 0	1,482				1,482
Issuance of common stock upon exercise of stock options, Shares	456,082		456,082
Warrant modification	$ 568			568
RSA issuances and forfeitures for terminations, net			$ 2	10,392				10,394
RSA issuances and forfeitures for terminations, net, Shares			1,613,553
Purchase/retirement of RSAs to satisfy employee tax withholding				(638)				(638)
Repurchase of shares to satisfy employee tax withholding, Shares			(104,842)
Ending Balance at Dec. 31, 2015	$ 212,857	$ 123	$ 68	552,108	(5,319)	(334,123)	$ 0	212,857
Ending Balance, Shares at Dec. 31, 2015	68,228,935	20	68,228,935				0
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Net income (loss)	$ (68,512)							(68,512)
Other comprehensive income (loss), net	$ 3,740				3,740			3,740
Issuance of common stock to 401(k) plan				953				953
Issuance of common stock to 401(k) plan, Shares			172,650
Issuance of common stock for ESPP				668				668
Issuance of common stock for ESPP, Shares			150,303
Issuance of common stock upon exercise of stock options			$ 0	202				202
Issuance of common stock upon exercise of stock options, Shares	39,010		39,010
RSA issuances and forfeitures for terminations, net			$ 1	11,459				11,460
RSA issuances and forfeitures for terminations, net, Shares			868,032
Purchase/retirement of RSAs to satisfy employee tax withholding				(1,397)				(1,397)
Repurchase of shares to satisfy employee tax withholding, Shares			(266,860)
Issuance of common stock for milestone achievement									$ 0	$ 2,308	$ 2,308	$ 0	$ 111	$ 111
Repurchase of 2018 Convertible Notes													$ (227)	$ (227)
Dividend paid on preferred shares						(6)		(6)
Issuance of common stock for milestone achievement, Shares									318,750			25,000
Common stock issued under an at-market-issuance sales agreement (Note 7)		$ 0	$ 11	73,858	0	0		73,869
Common stock under an at market issuance sales agreement, Shares	10,890,915	0	10,890,915
Conversion of preferred shares into common stock (Note 7)		$ (123)	$ 0	123	0	0		0
Conversion of preferred shares into common stock, Shares		(20)	40,000
Ending Balance at Dec. 31, 2016	$ 236,026	$ 0	$ 80	$ 640,166	$ (1,579)	$ (402,641)	$ 0	$ 236,026
Ending Balance, Shares at Dec. 31, 2016	80,466,735	0	80,466,735				0