Balance Sheet Account Detail - Summary of Other Assets (Detail) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2016	Dec. 31, 2015
Organization, Consolidation and Presentation of Financial Statements [Abstract]
Equity securities (see Note 11)	$ 11,533	$ 5,189
CASI note - long term (see Note 11)	1,510	1,500
Research & development supplies and other	224	185
2018 Convertible Notes issuance costs (excluding current portion)	0	0
Executive officer life insurance – cash surrender value	11,863	9,181
Inventories - non-current portion	4,419	3,156
Other assets	29,549	19,211
Unrealized loss	4,200
Accounting Standards Update 2015-03 [Member] | Long-term Debt [Member]
New Accounting Pronouncements or Change in Accounting Principle [Line Items]
Debt issuance costs	$ 1,300	$ 2,200