Consolidated Statements of Operations - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2016	Dec. 31, 2015	Dec. 31, 2014
Revenues:
Product sales, net	$ 128,596	$ 136,851	$ 186,537
License fees and service revenue	17,848	25,705	293
Total revenues	146,444	162,556	186,830
Operating costs and expenses:
Cost of product sales (excludes amortization and impairment charges of intangible assets)	27,953	27,689	27,037
Cost of service revenue	7,890	0	0
Selling, general and administrative	87,347	86,514	97,412
Research and development	58,936	50,766	69,662
Amortization and impairment charges of intangible assets	25,946	38,319	24,288
Total operating costs and expenses	208,072	203,288	218,399
Loss from operations	(61,628)	(40,732)	(31,569)
Other (expense) income:
Interest expense, net	(9,435)	(9,074)	(8,584)
Change in fair value of contingent consideration related to acquisitions	(649)	676	987
Other income (expense), net	887	(1,249)	(4,367)
Total other expenses	(9,197)	(9,647)	(11,964)
Loss before income taxes	(70,825)	(50,379)	(43,533)
Benefit (provision) for income taxes	2,313	(406)	(2,186)
Net loss	$ (68,512)	$ (50,785)	$ (45,719)
Net (loss) income per share: ($ per share)
Basic ($ per share)	$ (0.94)	$ (0.78)	$ (0.71)
Diluted ($ per share)	$ (0.94)	$ (0.78)	$ (0.71)
Weighted average shares outstanding: (shares)
Basic (shares)	72,824,070	64,882,417	64,708,163
Diluted (shares)	72,824,070	64,882,417	64,708,163