Consolidated Statements of Operations - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2015	Dec. 31, 2014	Dec. 31, 2013
Revenues:
Product sales, net	$ 136,851	$ 186,537	$ 143,475
License fees and service revenue	25,705	293	12,379
Total revenues	162,556	186,830	155,854
Operating costs and expenses:
Cost of product sales (excludes amortization and impairment of intangible assets)	27,689	27,037	28,580
Selling, general and administrative	86,514	97,412	99,315
Research and development	50,766	69,662	46,670
Amortization and impairment of intangible assets	38,319	24,288	20,074
Total operating costs and expenses	203,288	218,399	194,639
Loss from operations	(40,732)	(31,569)	(38,785)
Other (expense) income:
Interest expense, net	(9,074)	(8,584)	(2,192)
Change in fair value of contingent consideration related to acquisitions	676	987	2,871
Other (expense) income, net	(1,249)	(4,367)	1,470
Total other (expense) income	(9,647)	(11,964)	2,149
Loss before income taxes	(50,379)	(43,533)	(36,636)
Provision for income taxes	(406)	(2,186)	(25,498)
Net loss	$ (50,785)	$ (45,719)	$ (62,134)
Net (loss) income per share: ($ per share)
Basic ($ per share)	$ (0.78)	$ (0.71)	$ (1.02)
Diluted ($ per share)	$ (0.78)	$ (0.71)	$ (1.02)
Weighted average shares outstanding: (shares)
Basic	64,882,417	64,708,163	60,729,128
Diluted	64,882,417	64,708,163	60,729,128