Condensed Consolidated Statements of Cash Flows - USD ($) $ in Thousands	6 Months Ended
	Jun. 30, 2015	Jun. 30, 2014
Cash Flows From Operating Activities:
Net loss	$ (27,908)	$ (31,204)
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation and amortization	14,129	12,179
Stock-based compensation	5,990	5,525
Accretion of debt discount to interest expense on 2018 Convertible Notes (Note 11)	2,569	2,332
Amortization of deferred financing costs to interest expense on 2018 Convertible Notes (Note 11)	327	308
Bad debt (recovery) expense	0	(28)
Impairment of intangible assets (Note 3(f))	7,160	0
Unrealized foreign currency exchange loss	3,992	606
Research and development expense for the value of stock issued to TopoTarget in connection with milestone achievement	0	7,790
Change in fair value of contingent consideration related to acquisitions (Note 9)	646	1,729
Changes in operating assets and liabilities:
Accounts receivable, net	28,966	(7,231)
Other receivables	(2,757)	(4,263)
Inventories	398	2,638
Prepaid expenses	1,139	(197)
Deferred tax assets	(237)	72
Other assets	(2,991)	(1,873)
Accounts payable and other accrued obligations	(13,052)	(10,659)
Accrued payroll and benefits	(2,645)	(1,723)
Drug development liability	(1,296)	(554)
Deferred revenue	(2,531)	(123)
Deferred tax liability	184	602
Other long-term liabilities	905	(256)
Net cash provided by (used in) operating activities	12,988	(24,330)
Cash Flows From Investing Activities:
Redemption of certificate of deposit	0	165
Purchases of property and equipment	(212)	(605)
Net cash used in investing activities	(212)	(440)
Cash Flows From Financing Activities:
Proceeds from exercise of stock options	996	1,339
Proceeds from sale of stock under employee stock purchase plan	335	348
Purchase and retirement of restricted stock to satisfy employee tax liability at vesting	(515)	(590)
Net cash provided by financing activities	816	1,097
Effect of exchange rates on cash and equivalents	(1,263)	(228)
Net increase (decrease) in cash and cash equivalents	12,329	(23,901)
Cash and cash equivalents—beginning of period	129,942	156,306
Cash and cash equivalents—end of period	142,271	132,405
Supplemental disclosure of cash flow information:
Cash paid for income taxes	332	329
Cash paid for interest	$ 1,650	$ 1,588