EXHIBIT 10.1

                                 March 09, 2006


VIA U.S. MAIL

Ronald H. Bissinger


                  Re:   OFFER OF EMPLOYMENT

Dear Ron,

         o        On behalf of Alpha Innotech  Corporation I am pleased to offer
                  you a job in the exempt  position  of  COO/CFO.  If you accept
                  this offer, your starting wages at Alpha Innotech  Corporation
                  will be  $15,000.00  per month.  You will also be  eligible to
                  receive a  $20,000.00  bonus on March 15,  2007 as long as you
                  remain employed through March 15, 2007. In addition,  you will
                  receive 200,000 stock options  subject to Board approval.  The
                  incentive stock grant shall be exercisable with respect to 25%
                  of the total  number of ISO shares one year after the  Vesting
                  Base  Date and with  respect  to an  additional  1/48th of the
                  total  number  of ISO  shares  at the  end of each  month  and
                  thereafter,  so that the ISO shall be exercisable with respect
                  to all of the ISO  Shares on and after  four  years  after the
                  vesting base date,  subject  however to the Company's Right of
                  Repurchase.  The Vesting Base Date will be September 15, 2005.
                  In addition, you will accrue vacation at the rate of 1.25 days
                  per month (equivalent to 15 days of vacation  annually).

         o        By  accepting  this  offer,  you agree to start work for Alpha
                  Innotech Corporation on March 15, 2006.

                  Alpha  Innotech  Corporation  conditions  this offer upon your
providing   appropriate   documentation   of  United   States   citizenship   or
authorization  to work in the United States.  Also,  Alpha Innotech  Corporation
conditions this offer upon final approval of the Board.

                  You must disregard any statements or  representations  made to
you which would  subtract  from,  add to, or in any way change the terms of this
letter.  This letter cancels,  supersedes,  and takes  precedence over all other
statements and representations regarding the terms of your employment with Alpha
Innotech Corporation.

                  If you accept this offer,  your employment with Alpha Innotech
Corporation  will be  "at-will."  This  means  that your  employment  with Alpha
Innotech  Corporation  will not last for any specific  period of time and either
you or Alpha Innotech  Corporation can terminate your employment  without notice
and for any  reason  (good or bad) or for no reason  at all.  This  letter  will
reflect the final,  total and complete  agreement between you and Alpha Innotech
Corporation





regarding how your  employment  may be  terminated.  No other  agreements  exist
regarding the subject of termination.

                  Even though your job duties, title, compensation and benefits,
as well as Alpha Innotech Corporation's  personnel policies and procedures,  may
change from time to time during  your  tenure with Alpha  Innotech  Corporation,
neither you nor Alpha Innotech  Corporation  can change the "at-will"  nature of
your employment,  unless the CEO of Alpha Innotech  Corporation  signs a written
contract which explicitly changes your status as an "at-will"  employee.  Please
understand that any positive performance evaluations,  compliments,  promotions,
or pay increases you may happen to receive at Alpha Innotech  Corporation do not
indicate a change in your "at-will" status. Also, an employee's "at-will" status
does not change based upon length of service with Alpha Innotech Corporation.

                  In order to accept this offer, you must sign this letter and I
must  receive  it back  before  close of  business  on the  fifth  business  day
following the date of this letter (above).

                  We wish to  impress  on you that  you must not  bring to Alpha
Innotech Corporation any confidential or proprietary  information or material of
any former employer,  disclose or use such information or material in the course
of your  employment  with  Alpha  Innotech  Corporation,  or  violate  any other
obligation to your former employers.

                  I hope that you will  accept  our offer  and look  forward  to
having you join us. If you have any questions or do not  understand  any part of
this letter, please contact me before signing below.

                                   Sincerely,

                                   /s/ Haseeb Chaudhry
                                   --------------------------
                                   HASEEB CHAUDHRY
                                   CEO
                                   ALPHA INNOTECH CORPORATION

                  I, Ronald H.  Bissinger,  have read this letter and understand
its terms. By signing below, I accept the offer of employment this letter makes.


Date:  March 9, 2006               Signature:  /s/ Ronald H. Bissinger
      --------------                           -----------------------------
                                               RONALD H. BISSINGER