EXHIBIT 3.1.1

                            CERTIFICATE OF AMENDMENT
                                       OF
                              AMENDED AND RESTATED
                          CERTIFICATE OF INCORPORATION
                                       OF
                                  XTRANA, INC.


         The  undersigned,  James H.  Chamberlain,  Chief  Executive  Officer of
Xtrana, Inc. (the "Corporation"), a corporation organized and existing by virtue
of the General Corporation Law (the "GCL") of the State of Delaware, does hereby
certify pursuant to Section 103 of the GCL as to the following:

         1.       The name of the Corporation is Xtrana,  Inc. The original name
of the  Corporation  is Cytrx  Biopool,  Ltd.,  and the original  Certificate of
Incorporation  was filed with the Secretary of State of the State of Delaware on
January 7, 1987.

         2.       The terms and provisions of this  Certificate of Amendment (i)
have been approved by the Board of Directors of the  Corporation in a resolution
setting forth and declaring  advisable the amendment  contained  herein and (ii)
have been duly approved by the required number of shares of outstanding stock of
the Corporation,  in each case pursuant to and in accordance with Section 242 of
the General Corporation Law of the State of Delaware.

         3.       Article  I  of  the   Corporation's   Amended   and   Restated
Certificate of Incorporation is hereby amended and restated as follows:

   "The name of this corporation is Alpha Innotech Corp. (the "CORPORATION")."

         4.       Article  IV  of  the   Corporation's   Amended  and   Restated
Certificate of Incorporation is hereby amended and restated as follows:

              "The  total  number of shares of stock  which the  Corporation  is
     authorized  to issue is Fifty Million  (50,000,000),  all of which shall be
     Common Stock, par value $0.01 per shares. Simultaneously with the effective
     date  of  the  filing  of  this  amendment  to  the  Amended  and  Restated
     Certificate of Incorporation (the "Effective  Date"),  each share of Common
     Stock of the Corporation  issued and outstanding or held as treasury shares
     immediately  prior to the  Effective  Date (the "Old Common  Stock")  shall
     automatically be reclassified and continued (the "Reverse Split"),  without
     any action on the part of the holder  thereof,  as  one-tenth  on one share
     (0.1) of Common Stock. The Corporation shall not issue fractional shares on
     account  of the  Reverse  Split.  Holders  of Old  Common  Stock  who would
     otherwise  be  entitled  to a fraction of a share on account of the Reverse
     Split shall  receive,  upon  surrender of the stock  certificates  formerly
     representing  shares of the Old Common  Stock,  in lieu of such  fractional
     share, one whole share of Common Stock.

              The Corporation's authorized shares of Common Stock, each having a
     par  value of $0.01 per  share,  shall not be  changed.  The  Corporation's
     stated  capital  shall be reduced by an amount equal to the  aggregate  par
     value of the shares of Common Stock issued  prior to the  effectiveness  of
     this  Certificate  of  Amendment  which,  as a result of the Reverse  Split
     provided for herein, are no longer issued shares of Common Stock."





         IN WITNESS  WHEREOF,  the undersigned has executed this  Certificate of
Amendment of Amended and Restated Certificate of Incorporation as of the 3rd day
of October, 2005.

                                           /S/ JAMES H. CHAMBERLAIN
                                           -------------------------------------
                                           James H. Chamberlain,
                                           Chief Executive Officer


                                       2