EXHIBIT 3.1

                              AMENDED AND RESTATED
                          CERTIFICATE OF INCORPORATION
                                       OF
                           BIOPOOL INTERNATIONAL, INC.

         Pursuant to the General  Corporation Law of the State of Delaware,  the
undersigned,  being an  authorized  officer of Biopool  International,  Inc.,  a
Delaware   corporation,   hereby  adopts  the  following  Amended  and  Restated
Certificate of Incorproation.

                  FIRST: The original name of this corporation is Cytrx Biopool,
Ltd., and the date of filing of the original Certificate of Incorporation of the
corporation  with the  Secretary of State of the State of Delaware is January 7,
1987.

                  SECOND:  Pursuant  to  Section  242  and  245 of the  Delaware
General Corporation Law, this Amended and Restated  Certificate of Incorporation
restates and integrates  and further amends the provisions of the  corporation's
original Certificate of Incorporation as follows:

                                       I.

         The name of this Corporation is Xtrana, Inc. (the "Corporation").

                                       II.

         The  Corporation's  registered  office is located  at 2711  Centerville
Road, Suite 400, in the City of Wilmington,  in the County of New Castle, in the
State of Delaware 19808. The name of the registered agent at that address is The
Prentice-Hall Corporation System, Inc.

                                      III.

         The  purpose  of the  Corporation  is to  engage in any  lawful  act or
activity for which  corporations may be organized under the General  Corporation
Law of the State of Delaware (the "GCL").

                                       IV.

         The total number of shares of stock which the Corporation is authorized
to issue is Fifty Million (50,000,000),  all of which shall be Common Stock, par
value $0.01 per share.

                                       V.

         The Bylaws of the Corporation may be made, altered,  amended,  changed,
added to or repealed by the Board of Directors without the assent or vote of the
stockholders.  Elections of directors need not be by ballot unless the Bylaws so
provide.





                                       VI.

         The personal  liability of the directors of the  Corporation  is hereby
eliminated to the fullest extent permitted by paragraph (7) of subsection (b) of
Section 102 of the GCL, as the same may be amended and supplemented.

                                      VII.

         The Corporation  shall, to the fullest extent  permitted by Section 145
of the GCL, as amended  from time to time,  indemnify  all  persons  whom it may
indemnify pursuant thereto.

                                      VIII.

         The Corporation  reserves the right to amend, alter,  change, or repeal
any  provision  contained  in this  certificate  in the manner now or  hereafter
prescribed by law, and all rights and powers  conferred  herein on stockholders,
directors and officers are subject to this reserved power.



                  THIRD:   That  the  Amended  and   Restated   Certificate   of
Incorporation has been duly adopted by the Corporation's  Board of Directors and
a  majority  of its  voting  stockholders  in  accordance  with  the  applicable
provisions of Sections 242 and 245 of the GCL.

                  FOURTH: This Amended and Restated Certificate of Incorporation
shall be effective on the date filed with the Secretary of State of Delaware.


         IN WITNESS WHEREOF,  said corporation has caused this certificate to be
signed by the Chief Operating Officer of the Corporation on this June 21, 2001.

                                /S/ TIMOTHY J. DAHLTORP
                                --------------------------------------------
                                Timothy J. Dahltorp, Chief Operating Officer


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