UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549


                                    FORM 8-K

                                 CURRENT REPORT


                     Pursuant to Section 13 or 15(d) of the
                         Securities Exchange Act of 1934


       Date of Report (Date of earliest event reported): DECEMBER 31, 2004


                                  XTRANA, INC.
             (Exact name of registrant as specified in its charter)

           DELAWARE                   0-17714                   58-1729436
(State or other jurisdiction        (Commission               (IRS Employer
        of incorporation)           File Number)            Identification No.)


                P.O. BOX 668, SEDALIA, COLORADO                   80135
           (Address of principal executive offices)            (Zip Code)


                                 (303) 466-4424
              (Registrant's telephone number, including area code)


         Check the  appropriate  box below if the Form 8-K filing is intended to
simultaneously  satisfy the filing obligation of the registrant under any of the
following provisions (SEE General Instruction A.2. below):

         |_|      Written   communications   pursuant  to  Rule  425  under  the
                  Securities Act (17 CFR 230.425)

         |_|      Soliciting material pursuant to Rule 14a-12 under the Exchange
                  Act (17 CFR 240.14a-12)

         |_|      Pre-commencement  communications  pursuant  to  Rule  14d-2(b)
                  under the Exchange ct (17 CFR 240.14d-2(B))

         |_|      Pre-commencement  communications  pursuant  to Rule  13e-4(c))
                  under the Exchange Act (17 CFR 240.13e-4c))





ITEM 3.03         MATERIAL MODIFICATION TO RIGHTS OF SECURITY HOLDERS.

         As of December 31, 2004, Xtrana Inc.'s  stockholder rights plan expired
pursuant to its terms, as amended.

         Xtrana,  Inc.'s Board of Directors  previously approved an amendment to
the Rights  Agreement to accelerate the termination of the Rights Agreement from
June 12,  2008 to  December  31,  2004.  A copy of the Second  Rights  Agreement
Amendment between the Company and its transfer agent,  American Stock Transfer &
Trust Company, is attached hereto as Exhibit 4.1.


ITEM 9.01         FINANCIAL STATEMENTS AND EXHIBITS.

         (c)      Exhibits.

                  The following exhibits are filed herewith:

                  EXHIBIT
                  NUMBER   DESCRIPTION
                  -------  -----------

                  4.1      Second Rights  Agreement  Amendment  between  Xtrana,
                           Inc. and American Stock Transfer & Trust Company.


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                                    SIGNATURE

         Pursuant to the  requirements  of the Securities  Exchange Act of 1934,
the  Registrant  has duly  caused  this report to be signed on its behalf by the
undersigned hereunto duly authorized.


                                            XTRANA, INC.



Date:    January 5, 2005                    By:      /S/ JAMES CHAMBERLAIN
                                               ---------------------------------
                                                     James Chamberlain
                                                     Chief Executive Officer


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                                  EXHIBIT INDEX

EXHIBIT
NUMBER   DESCRIPTION
-------  -----------

4.1      Second Rights  Agreement  Amendment  between Xtrana,  Inc. and American
         Stock Transfer & Trust Company.


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