EXHIBIT 4.1

                        SECOND RIGHTS AGREEMENT AMENDMENT

         This Second Rights  Agreement  Amendment,  dated as of December 6, 2004
(this  "Amendment"),  to the  Rights  Agreement,  dated as of June 12,  1998 and
amended  as of March 1,  2000 (as  amended,  the  "Rights  Agreement"),  between
Xtrana, Inc., a Delaware  corporation  formerly known as Biopool  International,
Inc. (the  "Company") and American  Stock  Transfer & Trust  Company,  as Rights
Agent (the "Rights Agent").

         The Company and the Rights Agent have heretofore executed and delivered
the Rights  Agreement.  Pursuant  to Section  28 of the  Rights  Agreement,  the
Company  and the  Rights  Agent  may from time to time  supplement  or amend the
Rights Agreement in accordance with the provisions of Section 28 thereof.

         In  consideration of the foregoing  premises and mutual  agreements set
forth in the Rights  Agreement,  as  amended,  and this  Amendment,  the parties
hereto agree as follows:

         1. The "Final Expiration Date" as defined in Section 7(a) of the Rights
Agreement  (which  heretofore  was June  12,  2008) is  hereby  amended  to mean
December 31, 2004.

         2. This Amendment shall be governed by and construed in accordance with
the laws of the State of Delaware.

         3. This  Amendment  may be executed in any number of  counterparts  and
each of such counterparts shall for all purposes be deemed an original,  and all
such counterparts shall together constitute but one and the same instrument.

         4. Except as expressly set forth herein,  this  Amendment  shall not by
implication or otherwise  alter,  modify,  amend or in any way affect any of the
terms, conditions,  obligations, covenants or agreements contained in the Rights
Agreement,  all of which are  ratified  and  affirmed in all  respects and shall
continue in full force and effect.

         IN WITNESS WHEREOF, the parties hereto have caused this Amendment to be
duly executed as of the day and year first above written.

                                        XTRANA, INC.

                                        By:      /S/ JAMES CHAMBERLAIN
                                                 ------------------------------
                                                 James Chamberlain
                                        Title:   Chief Executive Officer

                                        AMERICAN STOCK TRANSFER & TRUST COMPANY

                                        By:      /S/ WILBERT MYLES
                                                 ------------------------------
                                                 Wilbert Myles
                                        Title:   Vice President