EXHIBIT 10.4.1

                   LEASE ADDENDUM TWO FOR MODIFICATION OF RENT
                    AND OPTION FOR EARLY TERMINATION OF LEASE

THIS ADDENDUM  DATED  November 11, 2003 (for  reference  purposes only) shall be
attached to and considered part of that certain Lease Agreement  entered into by
and between James M. Roswell d/b/a Burbank East Business Park, ("Landlord"), and
Biopool   International,   Inc.  d/b/a  Xtrana,  Inc.,  a  Delaware  Corporation
(Tenant"),  dated  December 19, 2001, as modified by the Lease  Addendum One for
Increase In Space Dated  December 21, 2001. For the promises  contained  herein,
and other good and valuable consideration,  the receipt and sufficiency of which
are hereby acknowledged, the parties agree as follows.

The following provisions shall hereby modify the aforementioned Lease Agreement,
as modified by the Lease  Addendum One for Increase In Space Dated  December 21,
2001.

1.       GROSS RENT  ABATEMENT.  Landlord and Tenant agree to a 6 month  partial
         abatement  of the Gross  Rent in the amount of $5,000 per month for a 6
         month period  commencing  on December 1, 2003,  and expiring on May 31,
         2004.  During this abatement time period,  Tenant shall pay Landlord as
         Gross  Rent  the  sum of  FOURTEEN-THOUSAND  EIGHT-HUNDRED  THIRTY-NINE
         DOLLARS AND 75/100  ($14,839.75)  on or before  December 1, 2003, and a
         like  sum on or  before  the  first  day of each and  every  successive
         calendar month  thereafter  and expiring  March 31, 2004.  Landlord and
         Tenant agree that  commencing on April 1, 2004, and expiring on May 31,
         2004,   Tenant   shall  pay   Landlord   as  Gross   Rent  the  sum  of
         FIFTEEN-THOUSAND   THREE-HUNDRED   THIRTY-FOUR   DOLLARS   AND   44/100
         ($15,334.44).

2.       ABATED RENT REPAYMENT.  This abated Gross Rent shall accrue interest at
         the rate of 6% per annum and shall be paid in full,  without  deduction
         or offset in lawful  money of the  United  States on or before  June 1,
         2004.  Commencing on June 1, 2004 the Gross Rent shall  continue at the
         unabated rate as set forth in the Lease  Agreement  and Lease  Addendum
         One on a monthly basis, continuing until the expiration of the lease as
         set forth in the Lease agreement and Lease Addendum One.

3.       AMENDMENT TO LETTER OF CREDIT.  On or before  December 1, 2003,  Tenant
         shall  provide  landlord  with a second  amendment  to the  Irrevocable
         Standby Letter of Credit No. STR19435,  dated April 9, 2002, as amended
         by the Amendment to Irrevocable  Standby Letter of Credit No.  STR19435
         dated  January  21,  2003,  to increase  the amount of the  Irrevocable
         Standby Letter of Credit to the sum of $137,500,  effective for the one
         year time period December 1, 2003 through December 1, 2004. On or after
         December 1, 2004,  Tenant shall provide Landlord with a third amendment
         to the  Irrevocable  Standby  Letter  of  Credit  reducing  the  sum to
         $62,046, as per the original Lease.

4.       OPTION FOR EARLY  TERMINATION OF LEASE.  After December 1, 2003, Tenant
         shall  have the  option  to effect  an early  termination  of the Lease
         Agreement,  as amended,  upon timely  notice and payment of one half of
         the remaining Base Rent due under the lease agreement,  plus payment of
         the abetted  Gross Rent,  plus accrued  interest  amount  referenced in
         paragraph 1 and 2 of this Lease  Addendum  Two,  less the amount of the
         security  deposit in the sum of $31,022.40,  plus any cost of repair or
         cleaning   as  provided   in   paragraph  6  of  the  Lease   Agreement
         ("Termination Payment").





         Tenant shall provide  Landlord  with written  notice of its election to
         exercise  its  option  for early  termination  sixty (60) days prior to
         termination.  In the  event  Tenant  exercises  its  option  for  early
         termination, and conditioned upon receipt of the Termination Payment as
         set forth in this paragraph,  the Irrevocable  Standby Letter of Credit
         No. STR19435 and Amendments thereto shall be null and void, and will be
         released  by  Landlord.  Landlord  agrees to  release  Tenant  from all
         obligations  under the Lease  Agreement upon receipt of the Termination
         Payment.

5.       MASTER LEASE. It is hereby agreed and understood  between  Landlord and
         Tenant  that  this  Lease  Addendum  does  not  apply  to any  Sublease
         Agreement.

6.       ALL OTHER TERMS AND  CONDITIONS  OF THE LEASE.  It is hereby agreed and
         understood  between  Landlord  and  Tenant  that all  other  terms  and
         conditions of the Lease Agreement and attachments, addenda and exhibits
         thereto, including, without limitation, Lease Addendum One for Increase
         in  Space,  shall be  unmodified  and shall  remain  in full  force and
         effect.






LANDLORD:                                       TENANT:

James M. Roswell
DBA Burbank East Business Park                  Biopool International, Inc.



     /s/ James M. Roswell
By:  /s/ James M. Roswell                      By:  /s/ Timothy J. Dahltorp
    ----------------------------                   -----------------------------
         James M. Roswell                               Timothy J. Dahltorp
                                                        Chief Financial Officer




Date: November 11, 2003                        Date: November 11, 2003