Via Facsimile and U.S. Mail
Mail Stop 6010
								December 28, 2005

Haseeb Chaudhry
Chief Executive Officer
Alpha Innotech Corp.
2401 Merced Street
San Leandro, California 94577


Re:	Alpha Innotech Corp.
      Item 4.01 Form 8-K
      Filed December 27, 2005
	File No. 001-14257


Dear Mr. Chaudhry:

      We have reviewed your filing and have the following
comments.
Where indicated, we think you should revise your document in
response
to these comments.  If you disagree, we will consider your
explanation as to why our comment is inapplicable or a revision is
unnecessary.  Please be as detailed as necessary in your
explanation.
After reviewing this information, we may raise additional
comments.

	Please understand that the purpose of our review process is
to
assist you in your compliance with the applicable disclosure
requirements and to enhance the overall disclosure in your filing.
We look forward to working with you in these respects.  We welcome
any questions you may have about our comments or any other aspect
of
our review.  Feel free to call us at the telephone number listed
at
the end of this letter.

Item 4.01(a)
1. Please amend the first  paragraph of your filing to state
whether
the former accountant resigned, declined to stand for re-election
or
was dismissed as required by Item 304(a)(1)(i) of Regulation S-B.
It
is not sufficient to state that the company "ended the engagement"
of
the accountant.

2. Please amend the second paragraph of your filing to state
whether
the principal accountant`s report on the financial statements for
either of the past two years contained an adverse opinion or
disclaimer of opinion.  Your current disclosure only covers the
most
recent year.  In addition, please amend the report to state
whether
during the registrant`s two most recent fiscal years and any
subsequent interim period preceding such resignation, declination
or
dismissal there were any disagreements with the former accountant.
Your current disclosure only covers the most recent fiscal year
end
and the subsequent interim period preceding the termination.

3. To the extent that you make changes to the Form 8-K to comply
with
our comments, please obtain and file an updated Exhibit 16 letter
from the former accountant stating whether the accountant agrees
with
the statements made in your revised Form 8-K.

 	As appropriate, please amend your filing and respond to these
comments within five business days or tell us when you will
respond.
You may wish to provide us with marked copies of the amendment to
expedite our review.  Please furnish a cover letter with your
amendment that keys your responses to our comments and provides
any
requested information.  Detailed cover letters greatly facilitate
our
review.  Please understand that we may have additional comments
after
reviewing your amendment and responses to our comments.

	We urge all persons who are responsible for the accuracy and
adequacy of the disclosure in the filing to be certain that the
filing includes all information required under the Securities
Exchange Act of 1934 and that they have provided all information
investors require for an informed investment decision.  Since the
company and its management are in possession of all facts relating
to
a company`s disclosure, they are responsible for the accuracy and
adequacy of the disclosures they have made.

	In connection with responding to our comments, please
provide,
in writing, a statement from the company acknowledging that:

* the company is responsible for the adequacy and accuracy of the
disclosure in the filing;

* staff comments or changes to disclosure in response to staff
comments do not foreclose the Commission from taking any action
with
respect to the filing; and

* the company may not assert staff comments as a defense in any
proceeding initiated by the Commission or any person under the
federal securities laws of the United States.


      In addition, please be advised that the Division of
Enforcement
has access to all information you provide to the staff of the
Division of Corporation Finance in our review of your filing or in
response to our comments on your filing.

	If you have any questions, please call me at (202) 551-3649.


							Sincerely,



							Vanessa Robertson
							Staff Accountant
??

??

??

??

Haseeb Chaudhry
Alpha Innotech Corp.
December 28, 2005
Page 1