SEC Form 3

FORM 3

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940

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1. Name and Address of Reporting Person* DAMASIO JOSEPH LUIS JR (Last) (First) (Middle) 10 LEWIS COURT (Street) NEW BEDFORD MA US 02740 (City) (State) (Zip)	2. Date of Event Requiring Statement (Month/Day/Year) 12/20/2011	3. Issuer Name and Ticker or Trading Symbol PRESSURE BIOSCIENCES INC [ PBIO ]
		4. Relationship of Reporting Person(s) to Issuer (Check all applicable) Director 10% Owner X Officer (give title below) Other (specify below) VP of Finance	5. If Amendment, Date of Original Filed (Month/Day/Year)
			6. Individual or Joint/Group Filing (Check Applicable Line) X Form filed by One Reporting Person Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Beneficially Owned
1. Title of Security (Instr. 4)	2. Amount of Securities Beneficially Owned (Instr. 4)	3. Ownership Form: Direct (D) or Indirect (I) (Instr. 5)	4. Nature of Indirect Beneficial Ownership (Instr. 5)

Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 4)	2. Date Exercisable and Expiration Date (Month/Day/Year)		3. Title and Amount of Securities Underlying Derivative Security (Instr. 4)		4. Conversion or Exercise Price of Derivative Security	5. Ownership Form: Direct (D) or Indirect (I) (Instr. 5)	6. Nature of Indirect Beneficial Ownership (Instr. 5)
	Date Exercisable	Expiration Date	Title	Amount or Number of Shares
Incentive Stock Option	(1)	02/12/2017	Common Stock	8,000	$3.51	D
Incentive Stock Option	(1)	09/25/2018	Common Stock	3,000	$2.75	D
Incentive Stock Option	(2)	03/12/2019	Common Stock	16,000	$0.77	D
Incentive Stock Option	(3)	09/09/2021	Common Stock	10,000	$1.05	D

Explanation of Responses:

1. Incentive Stock Options granted vest 1/3 per year over three years.

2. 1/3 of options vest immediately while 2/3 of options will vest ratably over two years.

3. Stock options have four year vesting period. 25% of the stock options will vest on the first anniversary while the remainder will vest monthly over the remaining three year vesting period.

	Joseph L Damasio Jr	12/23/2011
	** Signature of Reporting Person	Date
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 5 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
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