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Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
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 TWSM7vrzLADbmYQaionwg5sDW3P6oaM5D3tdezXMm7z1T+B+twIDAQAB
MIC-Info: RSA-MD5,RSA,
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 ivigE7eUuo05673sNhxB/g==

<SEC-DOCUMENT>0001144204-09-009447.txt : 20090217
<SEC-HEADER>0001144204-09-009447.hdr.sgml : 20090216
<ACCEPTANCE-DATETIME>20090217215136
ACCESSION NUMBER:		0001144204-09-009447
CONFORMED SUBMISSION TYPE:	4
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20090212
FILED AS OF DATE:		20090217
DATE AS OF CHANGE:		20090217

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Lawrence Nathan
		CENTRAL INDEX KEY:			0001355403

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-21615
		FILM NUMBER:		09617141

	BUSINESS ADDRESS:	
		BUSINESS PHONE:		508-580-1818

	MAIL ADDRESS:	
		STREET 1:		321 MANLEY STREET
		CITY:			WEST BRIDGEWATER
		STATE:			MA
		ZIP:			02379

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			PRESSURE BIOSCIENCES INC
		CENTRAL INDEX KEY:			0000830656
		STANDARD INDUSTRIAL CLASSIFICATION:	MEASURING & CONTROLLING DEVICES, NEC [3829]
		IRS NUMBER:				042652826
		STATE OF INCORPORATION:			MA
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		321 MANLEY STREET
		CITY:			WEST BRIDGEWATER
		STATE:			MA
		ZIP:			02379
		BUSINESS PHONE:		5085801818

	MAIL ADDRESS:	
		STREET 1:		321 MANLEY STREET
		CITY:			WEST BRIDGEWATER
		STATE:			MA
		ZIP:			02379

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	BOSTON BIOMEDICA INC
		DATE OF NAME CHANGE:	19960812
</SEC-HEADER>
<DOCUMENT>
<TYPE>4
<SEQUENCE>1
<FILENAME>v140610_ex.xml
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0303</schemaVersion>

    <documentType>4</documentType>

    <periodOfReport>2009-02-12</periodOfReport>

    <notSubjectToSection16>0</notSubjectToSection16>

    <issuer>
        <issuerCik>0000830656</issuerCik>
        <issuerName>PRESSURE BIOSCIENCES INC</issuerName>
        <issuerTradingSymbol>PBIO</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001355403</rptOwnerCik>
            <rptOwnerName>Lawrence Nathan</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>51 BELMONT STREET</rptOwnerStreet1>
            <rptOwnerStreet2>UNIT B-1, BLDG. 1</rptOwnerStreet2>
            <rptOwnerCity>EASTON</rptOwnerCity>
            <rptOwnerState>MA</rptOwnerState>
            <rptOwnerZipCode>02375</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>1</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>0</isOther>
            <officerTitle>Vice President of Marketing</officerTitle>
        </reportingOwnerRelationship>
    </reportingOwner>

    <derivativeTable>
        <derivativeTransaction>
            <securityTitle>
                <value>Series A Convertible Preferred Stock</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <value>1.15</value>
            </conversionOrExercisePrice>
            <transactionDate>
                <value>2009-02-12</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>P</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>522</value>
                </transactionShares>
                <transactionPricePerShare>
                    <footnoteId id="F3"/>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>A</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <exerciseDate>
                <value>2009-02-12</value>
                <footnoteId id="F1"/>
            </exerciseDate>
            <expirationDate>
                <footnoteId id="F2"/>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock, par value $.01 per share</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>5220</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>522</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                    <footnoteId id="F1"/>
                </directOrIndirectOwnership>
            </ownershipNature>
        </derivativeTransaction>
        <derivativeTransaction>
            <securityTitle>
                <value>15-Month Preferred Stock Purchase Warrant</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <value>12.50</value>
            </conversionOrExercisePrice>
            <transactionDate>
                <value>2009-02-12</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>P</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>522</value>
                </transactionShares>
                <transactionPricePerShare>
                    <footnoteId id="F3"/>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>A</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <exerciseDate>
                <value>2009-02-12</value>
                <footnoteId id="F1"/>
            </exerciseDate>
            <expirationDate>
                <value>2010-05-12</value>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock, par value $.01 per share</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>5220</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>522</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                    <footnoteId id="F1"/>
                </directOrIndirectOwnership>
            </ownershipNature>
        </derivativeTransaction>
        <derivativeTransaction>
            <securityTitle>
                <value>30-Month Common Stock Purchase Warrant</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <value>2.00</value>
            </conversionOrExercisePrice>
            <transactionDate>
                <value>2009-02-12</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>P</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>5220</value>
                </transactionShares>
                <transactionPricePerShare>
                    <footnoteId id="F3"/>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>A</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <exerciseDate>
                <value>2009-02-12</value>
                <footnoteId id="F4"/>
            </exerciseDate>
            <expirationDate>
                <value>2011-08-12</value>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock, par value $.01 per share</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>5220</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>5220</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                    <footnoteId id="F4"/>
                </directOrIndirectOwnership>
            </ownershipNature>
        </derivativeTransaction>
    </derivativeTable>

    <footnotes>
        <footnote id="F1">The terms of the Series A Convertible Preferred Stock contain a limitation on conversion which prevents the Reporting Person
 from converting shares of Series A Convertible Preferred Stock into shares of Common Stock
if, after giving effect to the conversion, the Reporting Person would beneficially own more than 4.99% of the outstanding
 shares of Common Stock. The Reporting Person may elect to increase this limitation to 9.99%, 14.99%
or 19.99%, upon not less than 61 days prior written notice to the Company. The Reporting Person disclaims beneficial
 ownership of such securities except to the extent of the Reporting Person's pecuniary interest in such
securities.</footnote>
        <footnote id="F2">The Series A Convertible Preferred Stock has no expiration date.</footnote>
        <footnote id="F3">Pursuant to a certain Securities Purchase Agreement, dated February 12, 2009, among the Company, the Reporting Person and the
 other purchasers named therein, the Reporting Person purchased 522 &quot;Units&quot; at a purchase
price of $11.50 per Unit. Each Unit consisted of (i) one share of Series A Convertible Preferred Stock, (ii) a warrant to
 purchase 10 shares of Common Stock, which warrant is exercisable until August 12, 2011 and (iii) a
warrant to purchase, at the Reporting Person's election, either one share of Series A Convertible Preferred Stock or 10
 shares of Common Stock, which warant is exercisable until May 12, 2010.</footnote>
        <footnote id="F4">The 30-Month Common Warrants contain a limitation on exercise which prevents the Reporting Person from exercising any
 Warrants if, after giving effect to the exercise, the Reporting Person would beneficially own
more than 4.99% of the outstanding shares of Common Stock. The Reporting Person may elect to increase this limitation to
 9.99%, 14.99% or 19.99%, upon not less than 61 days prior written notice to the Company. The
Reporting Person disclaims beneficial ownership of such securities except to the extent of the Reporting Person's pecuniary
 interest in such securities.</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>/s/ Richard T. Schumacher, Attorney in Fact for Nathan P. Lawrence</signatureName>
        <signatureDate>2009-02-17</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
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