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Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
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MIC-Info: RSA-MD5,RSA,
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<SEC-DOCUMENT>0001144204-07-015695.txt : 20070330
<SEC-HEADER>0001144204-07-015695.hdr.sgml : 20070330
<ACCEPTANCE-DATETIME>20070330163223
ACCESSION NUMBER:		0001144204-07-015695
CONFORMED SUBMISSION TYPE:	3
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20070320
FILED AS OF DATE:		20070330
DATE AS OF CHANGE:		20070330

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			PRESSURE BIOSCIENCES INC
		CENTRAL INDEX KEY:			0000830656
		STANDARD INDUSTRIAL CLASSIFICATION:	MEASURING & CONTROLLING DEVICES, NEC [3829]
		IRS NUMBER:				042652826
		STATE OF INCORPORATION:			MA
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		321 MANLEY STREET
		CITY:			WEST BRIDGEWATER
		STATE:			MA
		ZIP:			02379
		BUSINESS PHONE:		5085801818

	MAIL ADDRESS:	
		STREET 1:		321 MANLEY STREET
		CITY:			WEST BRIDGEWATER
		STATE:			MA
		ZIP:			02379

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	BOSTON BIOMEDICA INC
		DATE OF NAME CHANGE:	19960812

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Lazarev Alexander V
		CENTRAL INDEX KEY:			0001394174

	FILING VALUES:
		FORM TYPE:		3
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-21615
		FILM NUMBER:		07733232

	BUSINESS ADDRESS:	
		BUSINESS PHONE:		781-863-1856

	MAIL ADDRESS:	
		STREET 1:		18 WINCHESTER DRIVE
		CITY:			LEXINGTON
		STATE:			MA
		ZIP:			02420
</SEC-HEADER>
<DOCUMENT>
<TYPE>3
<SEQUENCE>1
<FILENAME>v069326_ex.xml
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0202</schemaVersion>

    <documentType>3</documentType>

    <periodOfReport>2007-03-20</periodOfReport>

    <noSecuritiesOwned>0</noSecuritiesOwned>

    <issuer>
        <issuerCik>0000830656</issuerCik>
        <issuerName>PRESSURE BIOSCIENCES INC</issuerName>
        <issuerTradingSymbol>PBIO</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001394174</rptOwnerCik>
            <rptOwnerName>Lazarev Alexander V</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>18 WINCHESTER DRIVE</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>LEXINGTON</rptOwnerCity>
            <rptOwnerState>MA</rptOwnerState>
            <rptOwnerZipCode>02420</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>1</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>0</isOther>
            <officerTitle>V.P. of Research &amp; Development</officerTitle>
        </reportingOwnerRelationship>
    </reportingOwner>

    <derivativeTable>
        <derivativeHolding>
            <securityTitle>
                <value>Employee Stock Option (right to buy)</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <value>3.88</value>
            </conversionOrExercisePrice>
            <exerciseDate>
                <footnoteId id="F1"/>
            </exerciseDate>
            <expirationDate>
                <value>2016-03-02</value>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>50000</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </derivativeHolding>
    </derivativeTable>

    <footnotes>
        <footnote id="F1">The option vests in three equal annual installments.  The first anniversary of the option grant was March 2, 2007.</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>/s/ Alexander V. Lazarev</signatureName>
        <signatureDate>2007-03-30</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
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