-----BEGIN PRIVACY-ENHANCED MESSAGE-----
Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
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 TWSM7vrzLADbmYQaionwg5sDW3P6oaM5D3tdezXMm7z1T+B+twIDAQAB
MIC-Info: RSA-MD5,RSA,
 Uangk1bAKrzYXD+TQknSc01h9+M3kNXnzzPbKdkjEEY++RWfnJQmOI8JlJAD5+ZU
 SicJtSaD96sPysocsGChUg==

<SEC-DOCUMENT>0001019056-06-000253.txt : 20060309
<SEC-HEADER>0001019056-06-000253.hdr.sgml : 20060309
<ACCEPTANCE-DATETIME>20060309160057
ACCESSION NUMBER:		0001019056-06-000253
CONFORMED SUBMISSION TYPE:	3
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20060308
FILED AS OF DATE:		20060309
DATE AS OF CHANGE:		20060309

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			PRESSURE BIOSCIENCES INC
		CENTRAL INDEX KEY:			0000830656
		STANDARD INDUSTRIAL CLASSIFICATION:	IN VITRO & IN VIVO DIAGNOSTIC SUBSTANCES [2835]
		IRS NUMBER:				042652826
		STATE OF INCORPORATION:			MA
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		321 MANLEY STREET
		CITY:			WEST BRIDGEWATER
		STATE:			MA
		ZIP:			02379
		BUSINESS PHONE:		5085801818

	MAIL ADDRESS:	
		STREET 1:		321 MANLEY STREET
		CITY:			WEST BRIDGEWATER
		STATE:			MA
		ZIP:			02379

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	BOSTON BIOMEDICA INC
		DATE OF NAME CHANGE:	19960812

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Lawrence Nathan
		CENTRAL INDEX KEY:			0001355403

	FILING VALUES:
		FORM TYPE:		3
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-21615
		FILM NUMBER:		06676237

	BUSINESS ADDRESS:	
		BUSINESS PHONE:		508-580-1818

	MAIL ADDRESS:	
		STREET 1:		321 MANLEY STREET
		CITY:			WEST BRIDGEWATER
		STATE:			MA
		ZIP:			02379
</SEC-HEADER>
<DOCUMENT>
<TYPE>3
<SEQUENCE>1
<FILENAME>edgar.xml
<DESCRIPTION>PRIMARY DOCUMENT
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0202</schemaVersion>

    <documentType>3</documentType>

    <periodOfReport>2006-03-08</periodOfReport>

    <noSecuritiesOwned>0</noSecuritiesOwned>

    <issuer>
        <issuerCik>0000830656</issuerCik>
        <issuerName>PRESSURE BIOSCIENCES INC</issuerName>
        <issuerTradingSymbol>PBIO</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001355403</rptOwnerCik>
            <rptOwnerName>Lawrence Nathan</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>1 WEST MAIN STREET</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>NEW MARKET</rptOwnerCity>
            <rptOwnerState>MD</rptOwnerState>
            <rptOwnerZipCode>21174</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>1</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>0</isOther>
            <officerTitle>VP Marketing &amp; Bus Development</officerTitle>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeHolding>
            <securityTitle>
                <value>Pressure BioSciences, Inc.</value>
            </securityTitle>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>2283</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value></value>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeHolding>
    </nonDerivativeTable>

    <derivativeTable>
        <derivativeHolding>
            <securityTitle>
                <value>Pressure BioSciences, Inc.</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <value>3.34</value>
            </conversionOrExercisePrice>
            <exerciseDate>
                <value>2006-08-05</value>
                <footnoteId id="F1"/>
            </exerciseDate>
            <expirationDate>
                <value>2015-08-05</value>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Pressure BioSciences, Inc.</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>50000</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value></value>
                </natureOfOwnership>
            </ownershipNature>
        </derivativeHolding>
        <derivativeHolding>
            <securityTitle>
                <value>Pressure BioSciences, Inc.</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <value>3.88</value>
            </conversionOrExercisePrice>
            <exerciseDate>
                <value>2007-03-02</value>
                <footnoteId id="F1"/>
            </exerciseDate>
            <expirationDate>
                <value>2017-03-02</value>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Pressure BioSciences, Inc.</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>10000</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value></value>
                </natureOfOwnership>
            </ownershipNature>
        </derivativeHolding>
    </derivativeTable>

    <footnotes>
        <footnote id="F1">Exercisable over three years (33% at the end of each year).</footnote>
    </footnotes>

    <remarks></remarks>

    <ownerSignature>
        <signatureName>/s/ NATHAN LAWRENCE</signatureName>
        <signatureDate>2006-03-08</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
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