EXHIBIT 24-1

                               POWER OF ATTORNEY

         Know all by these present, that the undersigned hereby constitutes and
appoints each of Richard T. Schumacher and Steven E. Hebert signing singly, the
undersigned's true and lawful attorney-in-fact to:

         (1)  execute for and on behalf of the undersigned, in the undersigned's
              capacity as an officer and/or director of Pressure BioSciences,
              Inc. (the "Company"), a Form ID - Uniform Application for Access
              Codes to File on Edgar and Forms 3, 4, and 5 in accordance with
              Section 16(a) of the Securities Exchange Act of 1934 and the rules
              promulgated thereunder;

         (2)  do and perform any and all acts for and on behalf of the
              undersigned which may be necessary or desirable to complete and
              execute any such Form 3, 4, or 5 and timely file such form with
              the United States Securities and Exchange Commission and any stock
              exchange or similar authority; and

         (3)  take any other action of any type whatsoever in connection with
              the foregoing which, in the opinion of such attorney-in-fact, may
              be of benefit to, in the best interest of, or legally required by,
              the undersigned, it being understood that the documents executed
              by such attorney-in-fact on behalf of the undersigned pursuant to
              this Power of Attorney shall be in such form and shall contain
              such terms and conditions as such attorney-in-fact may approve in
              such attorney-in-fact's discretion.

         The undersigned hereby grants to each such attorney-in-fact full power
and authority to do and perform any and every act and thing whatsoever
requisite, necessary, or proper to be done in the exercise of any of the rights
and powers herein granted, as fully to all intents and purposes as the
undersigned might or could do if personally present, with full power of
substitution or revocation, hereby ratifying and confirming all that such
attorney-in-fact, or such attorney-in-fact's substitute or substitutes, shall
lawfully do or cause to be done by virtue of this power of attorney and the
rights and powers herein granted. The undersigned acknowledges that the
foregoing attorneys-in-fact, in serving in such capacity at the request of the
undersigned, are not assuming, nor is the Company assuming, any of the
undersigned's responsibilities to comply with Section 16 of the Securities
Exchange Act of 1934.

         This Power of Attorney shall remain in full force and effect until the
undersigned is no longer required to file Forms 3, 4, and 5 with respect to the
undersigned's holdings of and transactions in securities issued by the Company,
unless earlier revoked by the undersigned in a signed writing delivered to the
foregoing attorneys-in-fact.

         IN WITNESS WHEREOF, the undersigned has caused this Power of Attorney
to be executed as of this 17th day of June 2005.


                                       /s/ R. WAYNE FRITZSCHE
                                       -----------------------------------------
                                       R. Wayne Fritzsche