BOSTON BIOMEDICA, INC.

                      Up to 633,306 Shares of Common Stock

     The shareholders named on page 14 are offering for sale up to 633,306
shares of our common stock under this prospectus.

     Our common stock is traded on the Nasdaq National Market under the symbol
"BBII." On December 7, 2000, the last reported sale price of our common stock
was $3.00 per share.

AN INVESTMENT IN THE COMMON STOCK OFFERED UNDER THIS PROSPECTUS INVOLVES A HIGH
DEGREE OF RISK. SEE "RISK FACTORS" BEGINNING ON PAGE 4.

NEITHER THE SECURITIES AND EXCHANGE COMMISSION NOR ANY STATE SECURITIES
COMMISSION HAS APPROVED OR DISAPPROVED OF THESE SECURITIES OR DETERMINED IF THIS
PROSPECTUS IS TRUTHFUL OR COMPLETE. ANY REPRESENTATION TO THE CONTRARY IS A
CRIMINAL OFFENSE.


                 The date of this prospectus is December 8, 2000


                                TABLE OF CONTENTS
                                                                      
SUMMARY...................................................................3
RISK FACTORS..............................................................4
WARNINGS REGARDING FORWARD-LOOKING STATEMENTS............................12
USE OF PROCEEDS..........................................................12
SELLING SHAREHOLDERS.....................................................14
PLAN OF DISTRIBUTION.....................................................15
INDEMNIFICATION FOR SECURITIES ACT LIABILITIES...........................16
LEGAL MATTERS............................................................17
EXPERTS..................................................................17
WHERE YOU CAN FIND MORE INFORMATION......................................18




                                       2



                                     SUMMARY

                             ABOUT BOSTON BIOMEDICA

     Boston Biomedica provides products and services for the detection and
treatment of infectious diseases such as AIDS, lyme disease, and viral
Hepatitis. We currently operate four business units:

     (1)  BBI Diagnostics, a manufacturer and seller of quality control and
          diagnostic products that increase the accuracy of diagnostic tests
          that are performed IN VITRO, in a test tube or other laboratory
          equipment;

     (2)  BBI Clinical Laboratories, a leading infectious disease testing
          laboratory that specializes in testing blood for the presence or
          absence of nucleic acids in pathogens, testing for tick borne diseases
          and follow-up testing for blood banks after an initial test shows
          questionable or positive results;

     (3)  BBI Biotech Research Laboratories, our research and development arm,
          which provides research and development support for our other business
          units and contract research services and specimen storage services for
          other parties, including various agencies of the National Institutes
          of Health; and,

     (4)  BBI Source Scientific, a manufacturer and seller of laboratory and
          medical instruments.

     In addition, we are also conducting research in a technology that
repeatedly applies and releases pressure on pathogens present in blood or plasma
in an effort to destroy them, with the goal of introducing new solutions for
improving blood plasma safety, for improving specimen preparation in the testing
of blood for the presence or absence of nucleic acids in pathogens and for
improving the treatment of infectious diseases.

     We were organized in Massachusetts in 1978 and commenced significant
operations in 1986. Our principal executive offices are located at 375 West
Street, West Bridgewater, Massachusetts 02379. Our telephone number is (508)
580-1900.

                                       3


                                  RISK FACTORS

BEFORE YOU BUY SHARES OF OUR COMMON STOCK, YOU SHOULD BE AWARE THAT THERE ARE
VARIOUS RISKS ASSOCIATED WITH THAT PURCHASE, INCLUDING THOSE DESCRIBED BELOW.
YOU SHOULD CONSIDER CAREFULLY THESE RISK FACTORS, TOGETHER WITH ALL OF THE OTHER
INFORMATION IN THIS PROSPECTUS AND THE DOCUMENTS WE HAVE INCORPORATED BY
REFERENCE IN THE SECTION "WHERE YOU CAN FIND MORE INFORMATION" BEFORE YOU DECIDE
TO PURCHASE SHARES OF OUR COMMON STOCK.

WE RELY ON PURCHASE ORDERS AND CONTRACTS FROM A SMALL NUMBER OF CUSTOMERS FOR A
LARGE PORTION OF OUR REVENUES; THE LOSS OF BUSINESS FROM THESE CUSTOMERS COULD
MATERIALLY REDUCE OUR REVENUES AND INCOME.

     Purchase orders account for the majority of our orders; none of our
customers have contractually committed to make future product purchases from us.
In 1999, our three largest customers, Hoffman-La Roche, Inc., Medilabs, Inc. and
Ortho-Diagnostics, Inc., together accounted for approximately 16% of our
revenues. In addition, the various agencies of the National Institutes of
Health, including the National Institutes of Allergies and Infectious Disease,
the National Cancer Institute and the National Heart Lung and Blood Institute,
in the aggregate accounted for approximately 15% of our revenues in 1999. Each
agency within the National Institutes of Health, however, makes independent
purchasing decisions. The loss of any major customer, including any agency
within the National Institutes of Health, or a material reduction in any major
customer's purchases would materially reduce our revenues and our operating
results.

IF WE ARE UNABLE TO INCREASE OUR SALES OF QUALITY CONTROL PRODUCTS TO END-USERS
OF INFECTIOUS DISEASE TEST KITS, THEN OUR FUTURE REVENUES COULD BE LESS THAN WE
HAVE PROJECTED.

     Currently, we sell most of our quality control products for infectious
disease test kits to test kit manufacturers and regulators, which is a
relatively small market. However, we also sell our quality control products to
end-users of infectious disease test kits, including hospital laboratories,
blood donor testing centers, public health laboratories and commercial
laboratories. This end-user market is a larger market which has not yet become
accustomed to using quality control products to monitor test results, but which
we believe is a growing market. Currently, we expect an increase in both the
frequency of use and the number of products used by our current end-user
customers. However, these end-users of infectious

                                       4


disease test kits may not increase their use of our products. Further, large
manufacturers and distributors of quality control products that have
historically sold to the non-infectious disease market and that have greater
financial, manufacturing and marketing resources than we have could begin
selling their products to the end-users of infectious disease test kits. If the
end-user market for quality control products for infectious disease testing does
not develop further, or if we are unable to increase sales of our products to
this market, our future revenues could be substantially less than we have
projected.

IF OUR BBI BIOSEQ, INC. AND BBI SOURCE SCIENTIFIC, INC. SUBSIDIARIES CONTINUE TO
HAVE SUBSTANTIAL OPERATING LOSSES, THEN WE MAY NOT BE ABLE TO REALIZE THE BOOK
VALUE OF THEIR ASSETS.

     Our BBI BioSeq subsidiary has incurred operating losses of approximately
$2,160,000, since its acquisition in September 1998, through September 30, 2000.
This subsidiary may not be successful in developing its in-process technology,
and its technology may never achieve commercial viability. If we cannot
successfully commercially develop its technology, our BBI BioSeq subsidiary may
never become profitable and we may need to write off some or all of the current
net book value of its intangible assets related to its patents, which was
approximately $681,000 as of September 30, 2000.

     As a result of our July 1997 acquisition of Source Scientific, Inc., we
recorded approximately $2,200,000 of goodwill. Since this acquisition, our BBI
Source Scientific subsidiary has incurred cumulative operating losses of
approximately $2,975,000, not including the write down of goodwill, as of
September 30, 2000. As of September 30, 2000, the net book value of goodwill
from the BBI Source Scientific acquisition of approximately $1,718,000 was
written down by approximately $1,464,000 to a balance of $254,000. That
subsidiary may continue to have operating losses and may never become
profitable. If operating losses continue, some or all of the remaining goodwill
associated with BBI Source Scientific may be written down or written off
entirely.

IF WE ARE UNABLE TO OBTAIN BOTH THE NECESSARY REGULATORY APPROVALS AND
SUBSTANTIAL FUNDS FOR OUR BBI BIOSEQ SUBSIDIARY'S PRODUCTS, OUR FUTURE REVENUES
AND INCOME WILL BE LESS THAN WE HAVE PROJECTED.

     Our BBI BioSeq subsidiary is currently developing products that will
require significant additional development, preclinical and clinical testing,
regulatory approvals and investment of substantial funds prior to their
commercialization. Our BBI BioSeq subsidiary is developing laboratory
instruments that will use pressure cycling technology, a technology that
repeatedly applies and releases pressure on

                                       5


pathogens present in blood or plasma in an effort to destroy them. Our BBI
BioSeq subsidiary is also developing its pressure cycling process to refine an
existing laboratory instrument prototype. Both the development of the laboratory
instruments and the pressure cycling process will require substantial capital
and development activities to ready the existing prototype for commercial use.
The process of obtaining required regulatory approvals can be costly and
time-consuming, and we may not be able to successfully develop our future
products, prove them to be safe and effective in clinical trials or receive
applicable regulatory approvals. If we are not able to obtain substantial funds,
develop adequate technology and receive regulatory approvals for products being
developed by our BBI BioSeq subsidiary, our future revenues and income will be
less than we have projected.

IF THE FDA REQUIRES CLEARANCE OR APPROVAL FOR EITHER OUR PRODUCTS THAT ARE
DESIGNATED ONLY FOR RESEARCH AND NOT FOR DIAGNOSTIC PROCEDURES OR OUR PRODUCTS
THAT WE BELIEVE ARE EXEMPT FROM FDA CLEARANCE AND INITIATES ENFORCEMENT ACTION
FOR OUR FAILURE TO DO SO, WE WILL LIKELY EXPEND SIGNIFICANT RESOURCES TO RESOLVE
THE MATTER.

     In the United States, the Food, Drug, and Cosmetic Act prohibits the
marketing of most IN VITRO diagnostic products until the Food and Drug
Administration either clears or approves the products through processes that are
time-consuming, expensive and uncertain. Some IN VITRO diagnostic products may
be exempt from FDA clearance or approval if they have undergone validation
studies. As of July 31, 2000, 31 of our Accurun 1(R) and Accurun(R) products had
received FDA clearance, and we believe that 17 are exempt from FDA clearance.
During 1999, our Accurun(R) products accounted for approximately 11.55% of our
revenue. Although it has not done so in the past, the FDA may not agree that
some of these products are entitled to an exemption and may adopt a different
interpretation of the Food, Drug, and Cosmetic Act or other laws it administers.
We believe that products which are used only for research and not in diagnostic
procedures are not subject to FDA clearance or approval. We currently label some
of our products "for research use only" because they are not intended for use in
diagnostic procedures, and have not been cleared or approved by the FDA. It is
possible, however, that some purchasers of these products may use them for
diagnostic purposes rather than for research, despite our labeling. Under any of
these circumstances, the FDA could allege that some or all of these products
should have been cleared or approved, or otherwise validated prior to marketing,
and could initiate enforcement action against us. If the FDA initiates
enforcement action against us, we will likely expend a large amount of time,
money, resources and management attention to resolve the matter. In addition, if
we cannot obtain or are delayed

                                       6


in obtaining FDA clearances or approvals for our products, we may encounter
delays or be unable to ever sell those products.

IF WE FAIL TO COMPLY WITH GOOD MANUFACTURING PRACTICES IN CONNECTION WITH THE
MANUFACTURE OF OUR MEDICAL DEVICE PRODUCTS, WE MAY NOT BE ABLE TO DISTRIBUTE OUR
PRODUCTS AND MAY NOT GENERATE PRODUCT REVENUES.

     We are also subject to strict FDA good manufacturing practice regulations
which govern testing, control and documentation practices, and other
post-marketing restrictions on the manufacture of our medical device products.
Our IN VITRO diagnostic products and our laboratory instrumentation products are
considered "medical device products," as defined by the FDA. Regulatory
authorities monitor our ongoing compliance with good manufacturing practices and
other applicable regulatory requirements through periodic inspections. If we
fail to comply with good manufacturing practices or other regulatory
requirements, we may not be able to obtain future pre-market clearances or
approvals, or the FDA or other regulatory agencies may impose corrective action
requirements, including total or partial suspension of product distribution,
injunctions, civil penalties, recall or seizure of products, and criminal
prosecution. Any of these events would lead to increased costs and a drain on
resources and could reduce our revenues and operating results.

BECAUSE WE CONDUCT OUR BUSINESS WORLDWIDE, CHANGES IN INTERNATIONAL REGULATORY
REQUIREMENTS MAY MATERIALLY REDUCE OUR TOTAL REVENUES.

     Our international sales accounted for approximately 13.7% of our total
revenues for the year ended December 31, 1999. Several Accurun(R) products are
subject to international regulatory approvals in Germany anD France. These
approval processes are similar to the FDA clearance process. Changes in
international regulatory requirements and policies, including both changes in
existing restrictions and future restrictions on importation of blood and blood
derivatives, could result in reduced international sales, which may materially
reduce our total revenues and income.

IF WE ARE UNABLE TO OBTAIN A STEADY AND ADEQUATE SUPPLY OF RARE SPECIMENS OF
PLASMA AND SERUM, THEN WE MAY BE UNABLE TO PRODUCE OUR QUALITY CONTROL PANEL
PRODUCTS AND OUR ACCURUN(R) RUN CONTROLS PRODUCTS.

     We manufacture our diagnostic products, including our quality control panel
products and Accurun(R) run controls products, from human plasma and serum which
we obtain from nonprofit and

                                       7


commercial blood centers in the United States and from similar sources
throughout the world. Our BBI Diagnostics business unit, which manufactures and
sells these diagnostic products, accounts for approximately 40% of our revenues.
Our quality control panel products and Accurun(R) run control products contain
unique and rare plasma specimens that we collect from individuals who have been
infected with particular diseases. The specimens are unique and rare because we
can collect them only during the brief period of time when the markers for a
particular disease in an infected individual are converting from negative to
positive. It is difficult to identify such infected individuals and to collect
specimens from them during the brief period of time when the markers for a
particular disease are converting from negative to positive. As a result,
quantities of these specimens are limited. As we sell our quality control panel
products and run control products, we must find replacement specimens that are
equally unique and rare. We may also face competition to obtain these specimens
which could further limit our ability to obtain the specimens and to produce our
quality control panel products and run control products. A limit in our ability
to produce our products would reduce our future revenues and operating results.

IF WE ARE NOT ABLE TO REACT QUICKLY TO TECHNOLOGICAL CHANGE, WE MAY NOT BE ABLE
TO COMPETE EFFECTIVELY.

     The infectious disease test kit industry is characterized by rapid and
significant technological change, and changes in customer requirements. As a
result, our ability to continue to compete effectively in this industry depends
upon our ability to enhance our existing products and to develop or acquire, and
introduce in a timely manner, new products that take advantage of technological
advances and respond to customer requirements. We may not be successful in
developing and marketing such new products or enhancements to our existing
products on a timely basis, if at all, and such products may not adequately
address the changing needs of the marketplace. Furthermore, rapid technological
development may result in our products or services becoming obsolete or
noncompetitive before we recover our investment in research, development and
commercialization.

IF WE CANNOT PROTECT OUR INTELLECTUAL PROPERTY, WE MAY BE UNABLE TO COMPETE
EFFECTIVELY.

     Our ability to compete effectively with other companies depends in part on
our ability to maintain the proprietary nature of our technologies and products.
We rely primarily on a combination of trade secrets and non-disclosure and
confidentiality agreements to establish and protect our proprietary rights in
our technology and products. We have 15 patents pending related to the pressure
cycling technology that

                                       8


our BBI BioSeq subsidiary is developing. If we have not adequately protected our
technology, or if our competitors misappropriate our intellectual property, we
could lose market share and our future revenues and operating income could be
significantly less than projected.

IF WE ARE UNABLE TO ATTRACT AND RETAIN HIGHLY QUALIFIED SCIENTIFIC AND
MANAGEMENT PERSONNEL, THEN WE MAY NOT BE ABLE TO DEVELOP AND REFINE OUR PRODUCTS
AND SERVICES.

     Our products and services are highly technical and our key personnel must
have specialized training or advanced degrees in order to develop and refine
these products and services. There are a limited number of qualified scientific
and management personnel who possess the technical background necessary to
adequately understand and improve our products and services. We compete for
these personnel with other companies, academic institutions, government entities
and other organizations engaged in research and development of quality control
products. If we are unable to attract and retain scientific and management
personnel with the appropriate credentials who are capable of developing and
refining our products and services, then our products and services could become
inaccurate or unreliable, or could fail to obtain FDA approval and we may be
unable to deliver new products.

PENDING LITIGATION COULD RESULT IN SUBSTANTIAL COSTS AND MAY DIVERT MANAGEMENT'S
ATTENTION AND RESOURCES.

     On August 18, 2000, we received a summons and complaint from Paradigm
Group, LLC, naming us as a defendant. Paradigm Group, LLC is a selling
shareholder in this registration statement. The suit, filed in the Circuit Court
of Cook County, Illinois, alleges breach of contract claims and fraud against us
in connection with the sale by us to them of warrants to purchase our shares of
common stock, the exercise of those warrants by Paradigm Group, LLC, and a delay
in the registration of those shares in this registration statement. Paradigm
Group, LLC, seeks several remedies, including $3 million in damages or
unspecified monetary damages, return of the $42,500 purchase price for the
warrants and rescission of its exercise of the warrants, and unspecified
punitive damages. We have announced that we intend to vigorously defend this
matter. This lawsuit could result in substantial costs and may divert
management's attention and resources. Any adverse determination in this case
could also subject us to significant liabilities.

                                       9


INSIDERS CONTROL A SIGNIFICANT PERCENTAGE OF VOTING POWER AND MAY EXERCISE THEIR
VOTING POWER IN A MANNER ADVERSE TO OTHER SHAREHOLDERS' INTERESTS.

     Our chief executive officer, Richard T. Schumacher, his relatives, and our
other existing officers and directors collectively have voting control over
approximately 35% of the outstanding shares of our common stock. Accordingly,
these shareholders, should they choose to act in concert, are in a position to
exercise a significant degree of control and to significantly influence
shareholder votes on the election of directors, increasing the authorized
capital stock, and authorizing mergers and sales of assets. These shareholders
may act in a manner that is adverse to your personal interests.

PROVISIONS IN OUR CHARTER AND BY-LAWS MAY DISCOURAGE OR FRUSTRATE SHAREHOLDERS'
ATTEMPTS TO REMOVE OR REPLACE OUR CURRENT MANAGEMENT.

     Our amended and restated articles of organization and restated bylaws
contain provisions that may make more difficult or discourage changes in our
management that our shareholders may consider to be favorable. These provisions
include:

  -  a classified board of directors;

  -  advance notice to the board of directors of shareholder proposals and
     shareholder nominees for the board of directors;

  -  limitations on the ability of shareholders to remove directors and call
     shareholders meetings; and

  -  a provision that allows a majority of the directors to fill vacancies on
     the board of directors.

     These provisions could prevent or frustrate shareholders' attempts to make
changes in our management that our shareholders consider to be beneficial.

THE CONVERSION OF OUR OUTSTANDING 3% SENIOR SUBORDINATED CONVERTIBLE DEBENTURES
AND/OR THE EXERCISE OF OUTSTANDING WARRANTS TO PURCHASE OUR COMMON STOCK WILL
HAVE A DILUTIVE IMPACT ON OUR SECURITY HOLDERS AND MAY PLACE DOWNWARD PRESSURE
ON THE PRICE OF OUR COMMON STOCK.

     The number of shares of common stock that may ultimately be issued upon
conversion of the outstanding debentures is presently undeterminable because the
conversion price of the debentures is the lower of: (i) $3.36 a share or (ii)
90% of the average of the five (5) lowest volume weighted average sales prices
of our common stock as reported by Bloomberg, L.P. during the 25 business days
immediately

                                       10


preceding the date on which any debenture holder notifies us that it will
convert all or a part of their debenture into common stock. Assuming a
conversion price of $3.36 a share, conversion of all our outstanding debentures
would result in the issuance of 967,262 shares of common stock. This represents
about 17.2% of our outstanding common stock based on the number of shares
outstanding as of September 19, 2000. In addition, the number of shares issuable
upon conversion of the debentures will increase if the price of our common stock
drops below $3.36 a share. For example, if the average of the five (5) lowest
volume weighted average sales prices of our common stock as reported by
Bloomberg, L.P. during the 25 business days immediately preceding the date on
which any debenture holder elects to convert all or a part of their debenture
into common stock is equal to $2.00 a share, and assuming all the debentures
were converted, we would issue approximately 1,625,000 shares of our common
stock, which represents approximately 28.8% of our issued and outstanding common
stock based on the number of shares outstanding as of September 19, 2000. A
downward spiral in the price of our common stock could result in the loss of a
significant portion of your investment, and the conversion of our outstanding
debentures could place downward pressure on the price of our common stock. The
terms of the debenture entitle us to redeem any of the outstanding debenture(s)
at a redemption price equal to (x) the number of shares of common stock into
which said debenture(s) is then convertible times (y) the average closing bid
price as reported by Bloomberg L.P. for the five (5) trading days immediately
prior to the date that the debenture(s) is called for redemption, plus accrued
and unpaid interest. We may not have sufficient funds to redeem the debentures
at such time as we determine it is most appropriate to redeem the debenture(s).

     In addition, we have outstanding warrants, with various strike prices,
which are exercisable for a total of 494,709 shares of our common stock
(warrants for 135,556 of which were issued to the selling shareholders named on
page 14). This represents approximately 8.8% of our issued and outstanding
common stock based on the number of shares issued and outstanding as of
September 19, 2000. The exercise of our outstanding warrants could place
downward pressure on the price of our common stock.

                                       11


                  WARNINGS REGARDING FORWARD-LOOKING STATEMENTS

     Some of the statements contained in this prospectus under "Summary" and
"Risk Factors," and in the documents incorporated by reference, are
forward-looking statements made pursuant to the safe harbor provisions of the
Private Securities Litigation Reform Act of 1995. In essence, forward-looking
statements are predictions of future events. Although we would not make
forward-looking statements unless we believe we have a reasonable basis for
doing so, we cannot guarantee their accuracy, and actual results may differ
materially from those we anticipated due to a number of uncertainties, many of
which we are not aware. We urge you to consider the risks and uncertainties
discussed under "Risk Factors" and in the other documents filed with the SEC
that we have referred you to in evaluating our forward-looking statements.

     You should also understand that we have no plans to update our
forward-looking statements. Our forward-looking statements speak only as of the
date of this prospectus, or in the case of forward-looking statements in
documents incorporated by reference, as of the date of those documents.

     We generally identify forward-looking statements with the words "plan,"
"expect," "anticipate," "believe," "intend," "estimate," "continue," "will,"
"may," "should" and similar expressions. Examples of our forward-looking
statements may include statements related to:

  -  our plans, objectives, expectations and intentions;

  -  the timing, availability, cost of development and functionality of products
     under development or recently introduced; and

  -  the anticipated markets for our products and the success of our products in
     those markets.

                                 USE OF PROCEEDS

     The selling shareholders are selling all of the shares covered by this
prospectus for their own account. Accordingly, we will not receive any proceeds
from the resale of the shares.

     However, the 633,306 shares of our common stock that we are registering
under this prospectus include shares that may be issued to selling shareholders
upon the conversion of outstanding stock purchase warrants.

                                       12


     Paradigm Group, L.L.C. obtained its shares upon the exercise of stock
purchase warrants that it received in connection with its investment in Boston
Biomedica. The total purchase price for the warrants was $50,000. David Kavrell,
Brian Friedman, Craig Gould, Steven Rothstein and Robert Daskal obtained their
shares upon the exercise of stock purchase warrants that they received by
transfer from Paradigm Group. These shareholders and Paradigm Group have agreed
to pay us a total of $2,225,000, as payment of the aggregate exercise price of
their warrants, on the business day after the SEC declares our registration
statement relating to these shares effective.

     National Securities received stock purchase warrants as a fee for services
rendered in connection with Paradigm Group's investment in Boston Biomedica.
National Securities may exercise warrants to purchase up to 40,000 shares of our
common stock at an exercise price of $4.25 per share and warrants to purchase up
to 25,000 shares of our common stock at an exercise price of $8.00 per share in
connection with Paradigm Group's exercise of its warrants. This transaction is
the subject of the litigation described under "Risk Factors" beginning on page
4. In addition, National Securities may exercise warrants to purchase up to
10,000 shares of our common stock at an exercise price of $5.25 per share.
National Securities' warrants expire on August 15, 2001.

     MdBio, Inc., received 29,153 stock units in connection with its award of
$175,000 to Boston Biomedica under a manufacturing incentive program that MdBio
instituted. Each stock unit consists of one share of our common stock and a
warrant to purchase one additional share of our common stock at an exercise
price of $10.00 per share. MdBio's warrants expire on September 29, 2003.

     We will use any proceeds which we will receive from the exercise of these
stock purchase warrants for working capital purposes.

     We prepared this prospectus to satisfy our obligations to the selling
shareholders to register their shares. We will bear the expenses relating to
this registration, other than selling discounts and commissions, which will be
paid by the selling shareholders.

                                       13


                              SELLING SHAREHOLDERS

     The selling shareholders named below are offering for sale up to 633,306
shares of our common stock under this prospectus. We will not receive any
proceeds from those sales. The 633,306 shares of our common stock that we are
registering under this prospectus include shares that may be issued to selling
shareholders upon the conversion of outstanding stock purchase warrants.

     The following table sets forth information regarding the beneficial
ownership of our common stock by the selling shareholders as of November 15,
2000 and as adjusted to reflect the sale or transfer by the selling shareholders
of the shares of our common stock being registered under this prospectus,
including the sale or transfer of shares of our common stock underlying warrants
held by selling shareholders. This information is based upon information
received from or on behalf of the selling shareholders.




                                     SHARES BENEFICIALLY      NUMBER OF   SHARES BENEFICIALLY
                                            OWNED            SHARES BEING      OWNED AFTER
                                      PRIOR TO OFFERING        OFFERED          OFFERING
NAME OF SECURITYHOLDER                NUMBER      PERCENT       NUMBER      NUMBER   PERCENT
                                                                      
Paradigm Group, L.L.C.(1)                425,000    7.76%       425,000       0        *
David Kavrell                             15,000        *        15,000       0        *
Brian Friedman                            10,000        *        10,000       0        *
Craig Gould                               20,000        *        20,000       0        *
Steven Rothstein                          20,000        *        20,000       0        *
Robert Daskal                             10,000        *        10,000       0        *
National Securities                       75,000(2) 1.37%        75,000       0        *
MdBio, Inc.                               58,306(3) 1.06%        58,306       0        *

- ------------------
*    Less than 1%.

(1)  Paradigm Group, L.L.C. is controlled by Sheldon Drobny.

(2)  Consists of warrants to purchase an aggregate of 75,000 shares of our
     common stock.

(3)  Consists of stock units comprised of 29,153 shares of our common stock and
     warrants to purchase an additional 29,153 shares of our common stock.

                                       14


                              PLAN OF DISTRIBUTION

     The selling shareholders and their pledgees, donees, transferees and other
non-sale transferees may offer their shares at various times in one or more of
the following transactions:

       -  in the Nasdaq National Market;

       -  in the over-the-counter market; or

       -  in privately negotiated transactions

at prevailing market prices at the time of sale, at prices related to those
prevailing market prices, at negotiated prices or at fixed prices.

     The selling shareholders may also sell the shares under Rule 144 instead of
under this prospectus, if Rule 144 is available for those sales.

     We will not receive any proceeds from the sale of our common stock by the
selling shareholders.

     The transactions in the shares covered by this prospectus may be carried
out by one or more of the following methods:

       -  ordinary brokerage transactions and transactions in which the broker
          solicits purchasers;

       -  purchases by a broker or dealer as principal, and the resale by that
          broker or dealer for its account as part of the distribution under
          this prospectus, including resale to another broker or dealer;

       -  block trades in which the broker or dealer will attempt to sell the
          shares as agent but may position and resell a portion of the block as
          principal in order to facilitate the transaction; or

       -  negotiated transactions between selling shareholders and purchasers,
          with or without a broker or dealer.

                                       15


     As of the date of this prospectus, we are not aware of any agreement,
arrangement or understanding between any broker or dealer and any of the selling
shareholders with respect to the offer or sale of the shares under this
prospectus.

     We have advised the selling shareholders that, during the time each is
engaged in distributing shares covered by this prospectus, each must comply with
the requirements of the Securities Act and the Exchange Act, including Rule
10b-5 and Regulation M. Under those rules and regulations, they:

       -  may not engage in any stabilization activity in connection with our
          securities;

       -  must furnish each broker that offers common stock covered by this
          prospectus with the number of copies of this prospectus that are
          required by each broker; and

       -  may not bid for or purchase any of our securities or attempt to induce
          any person to purchase any of our securities other than as permitted
          under the Exchange Act.

     Under the terms of each of the warrants, we have agreed to indemnify and
hold harmless each selling shareholder against liabilities under the Securities
Act, which may be based upon, among other things, any untrue statement or
alleged untrue statement of a material fact or any omission or alleged omission
of a material fact, unless made or omitted in reliance upon written information
provided to us by that selling shareholder for use in this prospectus. We have
agreed to bear the expenses incident to the registration of the shares, other
than selling discounts and commissions.


              INDEMNIFICATION FOR SECURITIES ACT LIABILITIES

         Our Amended and Restated Articles of Organization eliminate, subject to
certain exceptions, the personal liability of our directors for monetary damages
for breaches of fiduciary duties as directors. Our Restated Articles do not
provide for the elimination of, or any limitation on, the personal liability of
a director for (i) any breach of the director's duty of loyalty to Boston
Biomedica and our shareholders; (ii) acts or omissions not in good faith or
which involve intentional misconduct or a knowing violation of law; (iii)
certain unauthorized dividends, redemptions or distributions as provided under
Section 61 of the Massachusetts Business Corporation Law; (iv) certain loans of
company assets to any of our officers or directors as provided under Section 62
of the Massachusetts Business Corporation Law; or (v) any transaction from which
the director derived an improper personal benefit. This provision of our Amended
and Restated Articles of Organization will limit the remedies available to you
in the event of breaches of

                                       16


any director's duties to Boston Biomedica and our shareholders. Our Amended and
Restated Articles of Organization provide that we may, either in our by-laws or
by contract, provide for the indemnification of directors, officers, employees
and agents, by whomever elected or appointed, to the full extent permitted by
law.

     Insofar as indemnification for liabilities arising under the Securities Act
of 1933 may be permitted to our directors, officers or controlling persons
pursuant to the foregoing provisions, or otherwise, we have been informed that
in the opinion of the Securities and Exchange Commission such indemnification is
against public policy as expressed in the Securities Act and is, therefore,
unenforceable.

                                  LEGAL MATTERS

     For the purpose of this offering, Brown, Rudnick, Freed & Gesmer, Boston,
Massachusetts, will pass upon the validity of the shares of common stock covered
under this prospectus.

                                     EXPERTS

     The financial statements incorporated in this prospectus by reference to
the Annual Report on Form 10-K for the year ended December 31, 1999 have been so
incorporated in reliance on the report of PricewaterhouseCoopers LLP,
independent accountants, given on the authority of said firm as experts in
auditing and accounting. The valuation information incorporated in this
prospectus by reference to the Annual Report on Form 10-K for the year ended
December 31, 1999 has been so incorporated in reliance on the valuation report
of The Michel/Shaked Group, a division of Back Bay Management Corporation, given
on the authority of said firm as experts in asset valuation.


                                       17


                       WHERE YOU CAN FIND MORE INFORMATION

     We file annual, quarterly and special reports, proxy statements and other
information with the SEC. You may read and copy any document we file at the
SEC's public reference rooms at 450 Fifth Street, N.W., Washington, D.C., 20549,
in Chicago, Illinois and in New York, New York. Please call the SEC at
1-800-SEC-0330 for further information on the public reference rooms. Our SEC
filings are also available to the public over the Internet on the SEC's website
at http://www.sec.gov.

     We have filed with the SEC a registration statement on Form S-3 under the
Securities Act of 1933, as amended, with respect to the common stock offered in
connection with this prospectus. This prospectus does not contain all of the
information set forth in the registration statement. We have omitted parts of
the registration statement in accordance with the rules and regulations of the
SEC. For further information with respect to us and our common stock, you should
refer to the registration statement and to the exhibits and schedules filed as
part of the registration statement, as well as the documents discussed below.
Statements contained in this prospectus as to the contents of any contract or
other document are not necessarily complete and, in each instance, you should
refer to the copy of the contract or document filed as an exhibit to or
incorporated by reference in the registration statement. Each statement as to
the contents of any contract or document is qualified in all respects by
reference to the contract or document itself. You may obtain copies of the
registration statement from the SEC's principal office in Washington, D.C. upon
payment of the fees prescribed by the SEC, or you may examine the registration
statement without charge at the offices of the SEC described above.

     The SEC allows us to "incorporate by reference" the information that we
file with it, which means that we can disclose important information to you by
referring you to those documents. The information incorporated by reference is
considered to be part of this prospectus, and information that we file later
with the SEC will automatically update and supersede this information. We
incorporate by reference the following documents:

  -  Our Annual Report on Form 10-K for the fiscal year ended December 31, 1999,
     as amended;

  -  Our Quarterly Report on Form 10-Q for the fiscal quarter ended March 31,
     2000, as amended;

  -  Our Quarterly Report on Form 10-Q for the fiscal quarter ended June 30,
     2000, as amended;

  -  Our Quarterly Report on Form 10-Q for the fiscal quarter ended September
     30, 2000, as amended;

  -  Our Definitive Proxy Statement on Schedule 14A and proxy materials filed on
     May 1, 2000;

                                       18


  -  Our Current Report on Form 8-K filed on September 8, 2000; and

  -  The description of our common stock contained in our registration statement
     on Form 8-A dated October 25, 1996.

     We also incorporate by reference any future filings made with the SEC under
Sections 13(a), 13(c), 14 or 15(d) of the Securities Exchange Act of 1934, as
amended, prior to the termination of the offering to which this prospectus
relates.

     You may request a copy of any or all of these filings, at no cost, by
writing or telephoning us at the following address:

                           Boston Biomedica, Inc.
                           375 West Street
                           West Bridgewater, MA  02379
                           (508) 580-1900
                           Attn: Investor Relations

                                       19


THIS PROSPECTUS IS PART OF A REGISTRATION STATEMENT WE FILED WITH THE SEC. YOU
SHOULD RELY ONLY ON THE INFORMATION OR REPRESENTATIONS PROVIDED IN THIS
PROSPECTUS. WE HAVE NOT AUTHORIZED ANYONE TO PROVIDE YOU WITH ANY INFORMATION
THAT IS NOT CONTAINED IN THIS PROSPECTUS. THE SELLING SHAREHOLDERS DESCRIBED IN
THIS PROSPECTUS ARE NOT MAKING AN OFFER TO SELL OR SOLICITING AN OFFER TO BUY
ANY SHARES IN ANY JURISDICTION WHERE THE OFFER OR SALE IS NOT PERMITTED. YOU
SHOULD NOT ASSUME THAT THE INFORMATION IN THIS PROSPECTUS IS ACCURATE AS OF ANY
DATE OTHER THAN THE DATE OF THIS PROSPECTUS.

                             BOSTON BIOMEDICA, INC.

                      Up to 633,306 Shares of Common Stock

                                   PROSPECTUS

                              --------------------
                                TABLE OF CONTENTS
                              --------------------
                                                      
Summary                                                   3
Risk Factors                                              4
Warnings Regarding Forward-Looking Statements            12
Use of Proceeds                                          12
Selling Shareholders                                     14
Plan of Distribution                                     15
Indemnification for Securities Act Liabilities           16
Legal Matters                                            17
Experts                                                  17
Where You Can Find More Information                      18