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We consent to the inclusion in the Registration Statement on Form S-1 of Pressure BioSciences, Inc. of our report dated March 31, 2010, with respect to the consolidated financial statements of Pressure BioSciences, Inc. and Subsidiary as of December 31, 2009 and for the year then ended which appears in the Annual Report on Form 10-K of Pressure BioSciences, Inc. for the year ended December 31, 2010.

We also consent to the reference to our Firm under the heading “Experts” in such Registration Statement.