SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549

                                     FORM 15

     Certification and Notice of Termination of Registration Under Section 12(g)
of the Securities Exchange Act of 1934 or Suspension of Duty to File Reports
Under Sections 13 and 15(d) of the Securities Exchange Act of 1934

                         Commission File Number: 0-16946

                                  LabOne, Inc.
                         ------------------------------
              (Exact name of registrant as specified in its charter)

           10101 Renner Boulevard, Lenexa, Kansas 66219 (913) 888-1770
          -------------------------------------------------------------
    (Address, including zip code, and telephone number, including area code,
                  of registrant's principal executive offices)

                          Common Stock, $.01 par value
                         Preferred Stock Purchase Rights
                         -------------------------------
            (Title of each class of securities covered by this Form)

                                 Not Applicable
                                ----------------
       (Title of all other classes of securities for which a duty to file
                  reports under Section 13(a) or 15(d) remains)

       Please place an X in the box(es) to designate the appropriate rule
            provision(s) relied upon to terminate or suspend the duty
                                to file reports:

            Rule 12g-4(a)(1)(i)   (X)           Rule 12h-3(b)(1)(i)  (X)
            Rule 12g-4(a)(1)(ii)  ( )           Rule 12h-3(b)(1)(ii) ( )
            Rule 12g-4(a)(2)(i)   ( )           Rule 12h-3(b)(2)(i)  ( )
            Rule 12g-4(a)(2)(ii)  ( )           Rule 12h-3(b)(2)(ii) ( )
                                                Rule 15d-6           ( )

       Approximate number of holders of record as of the certification or
                              notice date: One (1)

     Pursuant to the requirements of the Securities Exchange Act of 1934,
LabOne, Inc. has caused this certification/notice to be signed on its behalf by
the undersigned duly authorized person.


      Date:  November 1, 2005         By: /s/ W. Thomas Grant, II
                                          -----------------------------
                                          W. Thomas Grant, II
                                          Chairman of the Board, President and
                                          Chief Executive Officer


Instruction: This form is required by Rules 12g-4, 12h-3 and 15d-6 of the
General Rules and Regulations under the Securities Exchange Act of 1934. The
registrant shall file with the Commission three copies of Form 15, one of which
shall be manually signed. It may be signed by an officer of the registrant, by
counsel or by any other duly authorized person. The name and title of the person
signing the form shall be typed or printed under the signature.