UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549


                                 SCHEDULE 13G/A


                    Under the Securities Exchange Act of 1934

                               (Amendment No. 23)*


                                  LABONE, INC.
- -------------------------------------------------------------------------------
                                (Name of Issuer)


                     Common Stock, $ .01 par value per share
- -------------------------------------------------------------------------------
                         (Title of Class of Securities)


                                   50540L 10 5
- -------------------------------------------------------------------------------
                                 (CUSIP Number)


                                December 31, 2000
- -------------------------------------------------------------------------------
             (Date of Event Which Requires Filing of This Statement)

Check the  appropriate box to designate the rule pursuant to which this Schedule
is filed:

           / /  Rule 13d-1(b)
           / /  Rule 13d-1(c)
           /X/  Rule 13d-1(d)

* The remainder of this cover page shall be filled out for a reporting  person's
initial filing on this form with respect to the subject class of securities, and
for any  subsequent  amendment  containing  information  which  would  alter the
disclosures provided in a prior cover page.

The information required in the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the  Securities  Exchange  Act of
1934 ("Act") or otherwise  subject to the liabilities of that section of the Act
but  shall be  subject  to all other  provisions  of the Act  (however,  see the
Notes).

                               Page 1 of 5 Pages




- -------------------------------------------------------------------------------

CUSIP NO. 50540L 10 5
- -------------------------------------------------------------------------------
(1)   Names of Reporting Persons
      I.R.S. Identification Nos. of Above Persons (entities only)

           William D. Grant
- -------------------------------------------------------------------------------
(2)   Check the Appropriate Box if a Member of a Group        (a)  / /
                                                              (b) / /
      Inapplicable
- -------------------------------------------------------------------------------
(3)   SEC Use Only
- -------------------------------------------------------------------------------
(4)   Citizenship or Place of Organization

      United States
- -------------------------------------------------------------------------------
                (5)  Sole Voting Power
                     915,972
Number of Shares
Beneficially
                -------------------------------------------------------------
Owned by        (6)  Shared Voting Power
Each                 908,020
Reporting
Person
                -------------------------------------------------------------
With:           (7)  Sole Dispositive Power
                     915,972

              -------------------------------------------------------------
                (8)  Shared Dispositive Power
                     908,020
- -------------------------------------------------------------------------------
(9)   Aggregate Amount Beneficially Owned By Each Reporting Person

      1,823,992
- -------------------------------------------------------------------------------
(10)  Check if the Aggregate Amount in Row (9) Excludes Certain Shares

      / /
- -------------------------------------------------------------------------------
(11)  Percent of Class Represented by Amount in Row (9)

      17.0%

                               Page 2 of 5 Pages




- -------------------------------------------------------------------------------
(12)  Type of Reporting Person

      IN
- -------------------------------------------------------------------------------

ITEM 1.

      (a)  Name of Issuer:

           LabOne, Inc.

      (b)  Address of Issuer's Principal Executive Offices:

           10101 Renner Boulevard
           Lenexa, Kansas  66219

ITEM 2.

      (a)  Name of Person Filing:

           William D. Grant

      (b)  Address of Principal Business Office or, if none, Residence:

           One Ward Parkway
           Suite 130
           Kansas City, MO  64112

      (c)  Citizenship:

           United States

      (d)  Title of Class of Securities:

           Common Stock, $ .01 par value per share

      (e)  CUSIP Number:

           50540L 10 5

ITEM 3. If this statement is filed pursuant to Sections  240.13d-1(b),  or
        240.13d-2(b) or (c), check whether the person filing is a:

        Not applicable.


                               Page 3 of 5 Pages




ITEM 4.    Ownership.

      (a)  Amount Beneficially Owned:  1,823,992 shares.

                The amount of shares  reported as  beneficially  owned includes:
           (i)  478,237  shares  held by three  family  trusts,  for  which  the
           reporting person acts as co-trustee with UMB Bank, N.A., Kansas City,
           Missouri,  and in that capacity shares voting and investment  powers;
           (ii)  295,158  shares  held by two  family  trusts,  as to which  the
           reporting  person has the right to direct the voting and  disposition
           of such shares,  and therefore  shares voting and  investment  powers
           with the trustee, UMB Bank, N.A.; (iii) 60,649 shares held by a trust
           for the benefit of a niece,  for which the  reporting  person acts as
           co-trustee  with UMB Bank,  N.A., and in that capacity  shares voting
           and  investment  powers,  as to which  shares  the  reporting  person
           disclaims beneficial  ownership;  and (iv) 73,976 shares owned by the
           reporting  person's  wife,  as to which shares the  reporting  person
           disclaims  beneficial  ownership.  The amount of shares  reported  as
           beneficially  owned also  includes  22,000 shares which the reporting
           person  has  the  right  to  acquire   within  60  days  pursuant  to
           exercisable stock options.

      (b)  Percent of Class:           17.0%

      (c)  Number of shares as to which the person has:

           (i)     sole power to vote or to direct the vote:    915,972

           (ii)    shared power to vote or to direct the vote:  908,020

           (iii)   sole power to dispose or to direct the disposition of:
                   915,972

           (iv)    shared power to dispose or to direct the disposition of:
                   908,020

ITEM 5.    Ownership of Five Percent or Less of a Class.

           Not applicable.

ITEM 6.    Ownership of More Than Five Percent on Behalf of Another Person.

           Each trust described in Item 4(a) hereof has the right to receive and
           the power to direct the receipt of  dividends  from,  or the proceeds
           from the sale of,  shares of Common  Stock of the Issuer held by such
           trust.

           Other persons have the right to receive  dividends on 908,020  shares
           of the securities listed in Item 4(a) above.


                               Page 4 of 5 Pages



ITEM 7.    Identification and Classification of the Subsidiary Which Acquired
           the Security Being Reported on by the Parent Holding Company.

           Not applicable.

ITEM 8.    Identification and Classification of Members of the Group.

           Not applicable.

ITEM 9.    Notice of Dissolution of Group.

           Not applicable.

ITEM 10.   Certification.

           Not applicable.

      After  reasonable  inquiry and to the best of my knowledge  and belief,  I
certify that the information  set forth in this statement is true,  complete and
correct.




                               /s/ W. D. Grant
                               ------------------------------------
                               W. D. Grant


Dated:  February  22, 2001
                  --
                               Page 5 of 5 Pages