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Income Taxes - Schedule of Effective Income Tax Rate Reconciliation (Details)
12 Months Ended
Dec. 31, 2022
Dec. 31, 2021
Dec. 31, 2020
Income Tax Disclosure [Abstract]      
U.S. Federal statutory tax rate 21.00% 21.00% 21.00%
State income taxes, net of federal benefit 3.00% (1.00%) 6.00%
Tax effect on stock option exercises, net of forfeitures 2.00% (44.00%) 4.00%
R&D tax credits and Orphan Drug credits (1.00%) 31.00% (2.00%)
Limitation on executive compensation 3.00% (60.00%) 9.00%
Change in valuation allowance 13.00% (40.00%) 9.00%
Transaction costs 3.00% 0.00% 0.00%
Foreign rate differential (2.00%) 4.00% (1.00%)
Other 0.00% (1.00%) 1.00%
Effective tax rate 42.00% (90.00%) 47.00%