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Common Stock and Stock-Based Compensation - Narrative (Details)
3 Months Ended 9 Months Ended 12 Months Ended 17 Months Ended 59 Months Ended
Sep. 24, 2020
USD ($)
$ / shares
shares
Mar. 31, 2021
milestone
$ / shares
shares
Sep. 30, 2021
USD ($)
shares
Sep. 30, 2020
USD ($)
shares
Dec. 31, 2020
USD ($)
Mar. 17, 2020
USD ($)
Jun. 30, 2021
USD ($)
shares
Sep. 23, 2020
USD ($)
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                
Payments to repurchase stock     $ 12,568,000 $ 27,999,000        
Award vesting period     4 years          
Volatility     56.07% 54.98%        
Expected term     5 years 8 months 4 days 6 years 10 days        
Expected dividend yield     0.00% 0.00%        
PSUs                
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                
Expired (in shares) | shares   97,750 97,750 11,431        
Granted (in shares) | shares     159,000 0        
Risk-free interest rate   0.18%            
Volatility   44.00%            
Expected term   3 years            
Expected dividend yield   0.00%            
PSUs | S&P Biotechnology                
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                
Granted (in shares) | shares   99,500,000            
Weighted average grant date fair value (in dollars per share) | $ / shares   $ 71.09            
Milestone PSUs                
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                
Granted (in shares) | shares   59,500            
Weighted average grant date fair value (in dollars per share) | $ / shares   $ 49.32            
Number of milestones | milestone   3            
Number of milestones required to be met | milestone   1            
Expiration period   3 years            
Expected achievement rate   0.00%            
Milestone PSUs | Minimum                
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                
Award vesting percentage of target number granted   0.00%            
Milestone PSUs | Maximum                
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                
Award vesting percentage of target number granted   200.00%            
Share Repurchase Programs                
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                
Payments to repurchase stock             $ 219,500,000  
Shares of common stock repurchased (in shares) | shares             3,941,541  
March 2020 Plan                
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                
Stock repurchase program, authorized amount           $ 160,000,000    
Accelerated share repurchases, authorized amount               $ 25,000,000
Accelerated share repurchases, payment $ 25,000,000              
Accelerated share repurchases, shares received (in shares) | shares 550,623              
Accelerated share repurchases, initial price paid per share (in dollars per share) | $ / shares $ 45.40              
Fair value adjustments related to derivative instrument         $ 3,000,000      
October 2018 Plan                
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                
Payments to repurchase stock           $ 68,000,000