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Balance Sheet Accounts - Accrued Expenses (Details) - USD ($)
$ in Thousands
Dec. 31, 2018
Dec. 31, 2017
Balance Sheet Related Disclosures [Abstract]    
Royalties payable to commercial partners $ 7,139 $ 4,310
Accrued research & development 1,245 936
Accrued professional fees 2,408 1,254
Accrued salary and other compensation 5,049 4,811
Accrued product costs 5,869 2,657
All other 1,809 1,423
Total Accrued expenses $ 23,519 $ 15,391