10-Q 1 o33633e10vq.htm QUARTERLY REPORT DATED SEPTEMBER 30, 2006 Quarterly Report dated September 30, 2006
 

 
 
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
WASHINGTON, D.C. 20549
FORM 10-Q
(Mark One)
     
þ   QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934
For the Quarterly Period Ended September 30, 2006
OR
     
o   TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934
Commission File No. 0-17082
QLT INC.
(Exact name of registrant as specified in its charter)
     
British Columbia, Canada   N/A
     
(State or other jurisdiction of incorporation or organization)   (I.R.S. Employer Identification No.)
     
887 Great Northern Way, Vancouver, B.C., Canada   V5T 4T5
     
(Address of principal executive offices)   (Zip code)
Registrant’s telephone number, including area code: (604) 707-7000
Indicate by check mark whether the registrant (1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during the preceding 12 months (or for such shorter period that the registrant was required to file such reports), and (2) has been subject to such filing requirements for the past 90 days. Yes þ       No o
Indicate by check mark whether the Registrant is a large accelerated filer, an accelerated filer, or a non-accelerated filer. See definition of “accelerated filer and large accelerated filer” in Rule 12b-2 of the Exchange Act.
Large accelerated filer þ       Accelerated filer o       Non-accelerated filer o
Indicate by check mark whether the registrant is a shell company (as defined in Rule 12b-2 of the Exchange Act). Yes o       No þ
As of November 6, 2006, the registrant had 75,172,770 outstanding Common Shares and 6,916,642 outstanding Stock Options.
 
 

 


 

QLT INC.
QUARTERLY REPORT ON FORM 10-Q
September 30, 2006
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 Section 302 C.E.O. Certification
 Section 302 C.F.O. Certification
 Section 906 C.E.O. Certification
 Section 302 C.F.O. Certification

 


 

PART I — FINANCIAL INFORMATION
ITEM 1. FINANCIAL STATEMENTS
QLT Inc.
CONSOLIDATED BALANCE SHEETS
(Unaudited)
                 
(In thousands of U.S. dollars)   September 30, 2006   December 31, 2005
 
ASSETS
               
Current assets
               
Cash and cash equivalents
  $ 210,275     $ 345,799  
Short-term investment securities
    144,752       119,816  
Restricted cash (Note 12)
    1,695        
Accounts receivable
    35,081       43,986  
Income taxes receivable
    7,010        
Inventories (Note 2)
    35,452       46,239  
Current portion of deferred income tax assets
    568       2,480  
Other (Note 3)
    17,755       20,728  
 
 
    452,588       579,048  
 
               
Property, plant and equipment
    52,495       52,797  
Assets held for sale (Note 9)
    21,929       29,626  
Deferred income tax assets
    14,773       7,593  
Goodwill
    103,958       103,958  
Other
    2,573       3,472  
 
 
  $ 648,316     $ 776,494  
 
 
               
LIABILITIES
               
Current liabilities
               
Accounts payable
  $ 12,962     $ 14,519  
Accrued liabilities (Note 4)
    9,983       17,901  
Income taxes payable
          17,253  
Accrued restructuring charge (Note 6)
    1,255       5,205  
Current portion of deferred revenue
    11,319       9,457  
 
 
    35,519       64,335  
 
               
Deferred income tax liabilities
    9,519       9,800  
Deferred revenue
    3,173       3,748  
Long-term debt
    172,500       172,500  
 
 
    220,711       250,383  
 
 
               
CONTINGENCIES (Note 12)
               
SHAREHOLDERS’ EQUITY
               
Share capital (Note 7)
               
Authorized
500,000,000 common shares without par value
5,000,000 first preference shares without par value, issuable in series
               
Issued and outstanding
Common shares
    707,885       861,676  
September 30, 2006 –75,170,300 shares
               
December 31, 2005–91,184,681 shares
               
Additional paid in-capital
    113,686       66,565  
Accumulated deficit
    (485,774 )     (501,645 )
Accumulated other comprehensive income
    91,808       99,515  
 
 
    427,605       526,111  
 
 
  $ 648,316     $ 776,494  
 

1


 

QLT Inc.
CONSOLIDATED STATEMENTS OF (LOSS) INCOME
(Unaudited)
                                 
    Three months ended   Nine months ended
    September 30,   September 30,
(In thousands of U.S. dollars except share and per share information)   2006   2005   2006   2005
 
Revenues
                               
Net product revenue (Note 8)
  $ 31,609     $ 55,892     $ 119,828     $ 161,874  
Net royalties
    6,118       3,879       14,948       11,492  
Contract research and development
    275       1,170       946       8,583  
Licensing and milestones
    244       189       732       502  
 
 
    38,246       61,130       136,454       182,451  
 
 
                               
Costs and expenses
                               
Cost of sales
    10,466       12,894       32,198       36,231  
Research and development
    13,564       15,701       43,704       47,030  
Selling, general and administrative
    10,040       8,016       27,614       17,450  
Depreciation
    1,622       1,804       4,727       4,901  
Amortization of intangibles
          983             4,078  
Restructuring charge (recovery)
    4       (3 )     (190 )     3,385  
 
 
    35,696       39,395       108,053       113,075  
 
 
                               
Operating income
    2,550       21,735       28,401       69,376  
 
                               
Investment and other income (expense)
                               
Net foreign exchange gains (losses)
    581       506       (2,886 )     3,696  
Interest income
    5,492       3,508       15,327       9,056  
Interest expense
    (1,636 )     (1,603 )     (4,854 )     (4,763 )
Other gains
    979       7       2,771       4  
 
 
    5,416       2,418       10,358       7,993  
 
 
                               
Income from continuing operations before income taxes
    7,966       24,153       38,759       77,369  
 
                               
Provision for income taxes
    (1,771 )     (9,863 )     (11,669 )     (28,024 )
 
 
                               
Income from continuing operations
    6,195       14,290       27,090       49,345  
 
 
                               
Loss from discontinued operations, net of income taxes (Note 9)
    (9,941 )     (1,391 )     (11,219 )     (4,364 )
 
                               
 
Net (loss) income
  $ (3,746 )   $ 12,899     $ 15,871     $ 44,981  
 
 
                               
Basic net (loss) income per common share
                               
Continuing operations
  $ 0.07     $ 0.15     $ 0.31     $ 0.53  
Discontinued operations
    (0.12 )     (0.02 )     (0.13 )     (0.05 )
 
Net (loss) income
  $ (0.04 )   $ 0.14     $ 0.18     $ 0.48  
 
 
                               
Diluted net (loss) income per common share
                               
Continuing operations
  $ 0.07     $ 0.15     $ 0.31     $ 0.52  
Discontinued operations
    (0.12 )     (0.02 )     (0.13 )     (0.04 )
 
Net (loss) income
  $ (0.04 )   $ 0.14     $ 0.18     $ 0.47  
 
 
                               
Weighted average number of common shares outstanding (thousands)
                               
Basic
    83,831       92,637       87,734       92,979  
Diluted
    83,831       92,919       87,785       103,293  
 

2


 

QLT Inc.
CONSOLIDATED STATEMENTS OF CASH FLOWS
(Unaudited)
                                 
    Three months ended   Nine months ended
    September 30,   September 30,
(In thousands of U.S. dollars)   2006   2005   2006   2005
 
Cash flows provided by (used in) operating activities
                               
Net (loss) income
  $ (3,746 )   $ 12,899     $ 15,871     $ 44,981  
Adjustments to reconcile net (loss) income to net cash
                               
From operating activities
                               
Amortization of intangibles
          1,327       78       5,109  
Depreciation
    1,768       2,139       5,438       5,867  
Writedown on investments
                432        
Writedown of inventory
    1,761             1,761        
Share based compensation
    1,033             3,141        
Impairment of goodwill and other intangibles (Note 9)
    1,928             1,928        
Impairment of fixed assets (Note 9)
    6,664             6,664        
Amortization of deferred financing expenses
    308       287       915       845  
Unrealized foreign exchange (gain) loss
    867       (3,718 )     (8,767 )     (79 )
Interest earned on restricted cash
    (20 )           (20 )      
Deferred income taxes
    (890 )     877       (5,303 )     1,375  
Loss on disposal of equipment
    4             23        
Changes in non-cash operating assets and liabilities
                               
Accounts receivable
    8,793       1,829       13,048       (203 )
Inventories
    2,517       651       10,167       3,099  
Other current assets
    1,149       (1,472 )     3,663       (7,142 )
Accounts payable
    1,202       (2,298 )     (4,282 )     (4,945 )
Income taxes payable
    (6,486 )     7,294       (24,450 )     19,065  
Accrued restructuring charge
    (343 )     (219 )     (4,014 )     590  
Other accrued liabilities
    (5,301 )     (596 )     (9,750 )     (8,570 )
Deferred revenue
    466       3,886       1,011       10,350  
 
 
    11,674       22,886       7,554       70,342  
 
 
                               
Cash provided by (used in) investing activities
                               
Short-term investment securities
    56,574       71,471       (18,940 )     (132,303 )
Restricted cash
                (1,675 )      
Purchase of property, plant and equipment
    (1,254 )     (1,551 )     (4,848 )     (4,724 )
Proceeds on disposal of property and equipment
                13        
Purchase costs related to Atrix Laboratories, Inc.
          (84 )     (14 )     (968 )
 
 
    55,320       69,836       (25,464 )     (137,995 )
 
 
                               
Cash (used in) provided by financing activities
                               
Common shares repurchased
    (104,250 )           (127,812 )     (15,537 )
Issuance of common shares
    92       225       691       11,266  
 
 
    (104,158 )     225       (127,121 )     (4,271 )
 
 
                               
Effect of exchange rate changes on cash and cash equivalents
    (419 )     7,388       9,505       1,535  
 
                               
 
 
                               
Net (decrease) increase in cash and cash equivalents
    (37,583 )     100,335       (135,526 )     (70,389 )
Cash and cash equivalents, beginning of period
    247,858       106,363       345,801       277,087  
 
 
                               
Cash and cash equivalents, end of period
  $ 210,275     $ 206,698     $ 210,275     $ 206,698  
 
 
                               
Supplementary cash flow information:
                               
Interest paid
  $ 2,729     $ 2,742     $ 5,603     $ 5,613  
Income taxes paid
    8,095       1,522       40,306       5,560  
 

3


 

QLT Inc.
CONSOLIDATED STATEMENTS OF CHANGES IN SHAREHOLDERS’ EQUITY
(Unaudited)
                                                         
                            Accumulated                    
    Common Shares   Additional   Other                   Total
                    Paid-in   Comprehensive   Accumulated   Comprehensive   Shareholders’
    Shares   Amount   Capital   Income   Deficit   Income (loss)   Equity
 
(All amounts except share and per share information are expressed in thousands of U.S. dollars)
 
Balance at December 31, 2004
    92,021,572     $ 848,498     $ 92,193     $ 89,882 (1)   $ (173,794 )         $ 856,779  
 
                                                       
Exercise of stock options at prices ranging from CAD $12.10 to CAD $13.35 per share and U.S. $2.63 to U.S. $16.22 per share
    1,304,509       25,068       (15,593 )                       9,475  
 
                                                       
Exercise of warrant at U.S. $3.39 per share
    1,000,000       19,594       (16,204 )                       3,390  
 
                                                       
Common share repurchase
    (3,141,400 )     (31,484 )     6,169             (2,439 )           (27,754 )
 
                                                       
Other comprehensive income:
                                                       
Cumulative translation adjustment from application of U.S. dollar reporting
                      9,792             $     9,792       9,792  
 
                                                       
Unrealized (loss) on available for sale securities
                      (159 )           (159 )     (159 )
 
                                                       
Net income
                            (325,412 )     (325,412 )     (325,412 )
 
                                                       
Comprehensive income
                                  $(315,779 )      
 
Balance at December 31, 2005
    91,184,681     $ 861,676     $ 66,565     $ 99,515 (1)   $ (501,645 )         $ 526,111  
 
                                                       
Exercise of stock options at prices ranging from U.S. $4.73 to U.S. $6.54 per share.
    30,359       559       (386 )                       173  
 
                                                       
Stock based compensation
                1,244                         1,244  
 
                                                       
Common share repurchase
    (1,726,000 )     (18,155 )     5,193                         (12,962 )
 
                                                       
Other comprehensive income:
                                                       
Cumulative translation adjustment from application of U.S. dollar reporting
                      (1,785 )           $    (1,785 )     (1,785 )
Unrealized gain on available for sale securities
                      25             25       25  
 
                                                       
Net income
                            12,133       12,133       12,133  
 
                                                       
Comprehensive income
                                  $   10,373        
 
Balance at March 31, 2006
    89,489,040     $ 844,081     $ 72,614     $ 97,755 (1)   $ (489,512 )         $ 524,938  
 
                                                       
Exercise of stock options at prices ranging from U.S. $5.22 to U.S. $7.88 per share.
    60,631       1,229       (805 )                       424  
 
                                                       
Stock based compensation
                1,058                         1,058  
 
                                                       
Common share repurchase
    (1,397,000 )     (15,280 )     4,683                         (10,597 )
 
                                                       
Other comprehensive income:
                                                       
Cumulative translation adjustment from application of U.S. dollar reporting
                      13,325             $   13,325       13,325  
 
                                                       
Unrealized gain on available for sale securities
                      198             198       198  
 
                                                       
Net income
                            7,484       7,484       7,484  
 
                                                       
Comprehensive income
                                  $   21,007        
 
Balance at June 30, 2006
    88,152,671     $ 830,030     $ 77,550     $ 111,278 (1)   $ (482,028 )         $ 536,830  

4


 

                                                         
                            Accumulated                    
    Common Shares   Additional   Other                   Total
                    Paid-in   Comprehensive   Accumulated   Comprehensive   Shareholders’
    Shares   Amount   Capital   Income   Deficit   Income (loss)   Equity
 
(All amounts except share and per share information are expressed in thousands of U.S. dollars)
 
Exercise of stock options at prices ranging from U.S. $2.89 to U.S. $7.88 per share.
    17,629       279       (187 )                       92  
 
                                                       
Stock based compensation
                1,061                         1,061  
 
                                                       
Common share repurchase
    (13,000,000 )     (122,423 )     35,261                         (87,162 )
 
                                                       
Other comprehensive income:
                                                       
Cumulative translation adjustment from application of U.S. dollar reporting
                      (19,468 )           $(19,468 )     (19,468 )
 
                                                       
Unrealized loss on available for sale securities
                      (3 )           (3 )     (3 )
 
                                                       
Net loss
                            (3,746 )     (3,746 )     (3,746 )
 
                                                       
Comprehensive loss
                                  $(23,217 )      
 
Balance at September 30, 2006
    75,170,300     $ 707,886     $ 113,686     $ 91,808 (1)   $ (485,774 )         $ 427,605  
 
(1)   At December 31, 2005, March 31, June 30, and September 30, 2006 our accumulated other comprehensive income is related almost entirely to cumulative translation adjustments from the application of U.S. dollar reporting with an insignificant amount due to unrealized gain (loss) on available for sale securities.

5


 

NOTES TO THE CONSOLIDATED FINANCIAL STATEMENTS
1. SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES
Business
We are a global biopharmaceutical company dedicated to the discovery, development and commercialization of innovative therapies. Our research and development efforts are focused on the discovery and development of pharmaceutical products in the fields of ophthalmology and dermatology. In addition, we utilize our two unique technology platforms, photodynamic therapy and atrigel, to create products such as Visudyne and Eligard. All references to “QLT”, the “Company”, “we” or “us” include QLT Inc., QLT USA, Inc. and our other subsidiaries.
Basis of Presentation
These unaudited consolidated financial statements have been prepared in accordance with accounting principles generally accepted in the United States and pursuant to the rules and regulations of the United States Securities and Exchange Commission for the presentation of interim financial information. Accordingly, certain information and footnote disclosures normally included in financial statements prepared in accordance with United States generally accepted accounting principles have been condensed, or omitted, pursuant to such rules and regulations. These financial statements do not include all disclosures required for annual financial statements and should be read in conjunction with our audited consolidated financial statements and notes thereto included as part of our Annual Report on Form 10-K for the year ended December 31, 2005. All amounts are expressed in United States dollars unless otherwise noted.
In February 2006, we initiated an active plan to divest of certain non-core assets, including the generic dermatology business, dental business and the related manufacturing facility owned by our subsidiary, QLT USA, Inc. in Fort Collins, Colorado. As a result, the consolidated financial statements for 2005 have been restated for comparative purposes to present the results of the generic dermatology and dental businesses as discontinued operations, and the assets included as part of this divestiture have been reclassified as held for sale. (See Note 9 — “Discontinued Operations”.)
In the opinion of management, all adjustments (including reclassifications and normal recurring adjustments) necessary to present fairly the financial position, results of operations and cash flows at September 30, 2006, and for all periods presented, have been made. Interim results are not necessarily indicative of results for a full year.
Principles of Consolidation
These consolidated financial statements include the accounts of QLT Inc. and its subsidiaries, all of which are wholly owned. The principal subsidiary included in our consolidated financial statements is QLT USA, Inc., incorporated in the state of Delaware in the United States of America. All significant intercompany transactions have been eliminated.
Use of Estimates
The preparation of financial statements in conformity with generally accepted accounting principles requires management to make estimates and assumptions that affect the reported amounts of assets and liabilities, the disclosure of contingent assets and liabilities at the date of the financial statements, and the reported amounts of revenue and expenses during the reporting periods presented. Significant estimates are used for, but not limited to, provisions for non-completion of inventory, provision for obsolete inventory, allowance for doubtful accounts, assessment of the recoverability of long-lived assets, assessment of impairment of goodwill, accruals for contract manufacturing and research and development agreements, accruals for compensation expenses, allocation of costs to manufacturing under a standard costing system, allocation of overhead expenses to research and development, determination of fair value of assets and liabilities acquired in purchase business combinations, stock-based compensation, and provisions for taxes and contingencies. Actual results may differ from estimates made by management.
Reporting Currency and Foreign Currency Translation
We use the U.S. dollar as our reporting currency, while the Canadian dollar is the functional currency for QLT Inc. and the U.S. dollar is the functional currency for our U.S. subsidiaries. Our consolidated financial statements are translated into U.S. dollars using the current rate method. Assets and liabilities are translated at the rate of exchange prevailing at the balance sheet date. Shareholders’ equity is translated at the applicable historical rates. Revenues and expenses are translated at a weighted average rate of exchange for the respective years. Translation gains and losses from the application of the U.S. dollar as the reporting currency are included as part of the cumulative foreign currency translation adjustment, which is reported as a component of shareholders’ equity under accumulated other comprehensive income (loss).

6


 

Segmented Information
We operate in one industry segment, which is the business of developing, manufacturing, and commercialization of therapeutics for human health care. Our chief operating decision makers review our operating results on an aggregate basis and manage our operations as a single operating segment. Our segment information does not include the results of businesses classified as discontinued operations.
Long-lived and Intangible Assets
We incur costs to purchase and occasionally construct property, plant and equipment. The treatment of costs to purchase or construct these assets depends on the nature of the costs and the stage of construction. Costs incurred in the initial design and evaluation phase, such as the cost of performing feasibility studies and evaluating alternatives, are charged to expense. Costs incurred in the committed project planning and design phase, and in the construction and installation phase, are capitalized as part of the cost of the asset. We stop capitalizing costs when an asset is substantially completed and ready for its intended use. We depreciate plant and equipment using the straight-line method over their estimated economic lives, which range from 3-40 years. Determining the economic lives of plant and equipment requires us to make significant judgements that can materially impact our operating results.
In accounting for acquisitions, we allocate the purchase price to the fair value of the acquired tangible and intangible assets, including in-process research and development, or IPR&D. We generally estimate the value of acquired tangible and intangible assets and IPR&D using a discounted cash flow model, which requires us to make assumptions and estimates about, among other things: the time and investment that is required to develop products and technologies; our ability to develop and commercialize products before our competitors develop and commercialize products for the same indications; the amount of revenue to be derived from the products; the probability of success of products in development and appropriate discount rates to use in the analysis. Use of different estimates and judgements could yield materially different results in our analysis, and could result in materially different asset values and IPR&D charges.
We periodically evaluate our long-lived assets for potential impairment under SFAS 144, Accounting for the Impairment or Disposal of Long-lived Assets. We perform these evaluations whenever events or changes in circumstances suggest that the carrying amount of an asset or group of assets is not recoverable. If impairment recognition criteria in SFAS 144 have been met, we charge impairments of the long-lived assets to operations.
As of September 30, 2006, we have $4.9 million of net acquired intangibles, all of which relates to the generic dermatology products acquired as part of the acquisition of Atrix Laboratories, Inc., or Atrix (now QLT USA, Inc.). We previously amortized acquired intangible assets using the straight-line method over their estimated economic lives, which range from 16 to 17 years. During the first quarter of 2006, we initiated an active plan to divest certain non-core assets, including the generic dermatology business, and reclassified our acquired intangible assets for current and prior periods as assets held for sale and ceased recording amortization expense.
Goodwill Impairment
In accordance with Statement of Financial Accounting Standard, or SFAS 142, Goodwill and Other Intangibles, we are required to perform impairment tests annually or whenever events or changes in circumstances suggest that the carrying value of an asset may not be recoverable. Assumptions and estimates were made regarding product development, market conditions and cash flows that were used to determine the valuation of goodwill and intangibles, all of which related to our acquisition of Atrix. During the quarter ended September 30, 2006, we performed our annual impairment test, and we did not identify any potential impairment as the fair value of our reporting unit exceeded its carrying amount. Impairment tests may be required in future periods before our next annual test as a result of changes in forecasts and estimates, and may result in impairment charges which could materially impact our future reported results.
Assets Held for Sale and Discontinued Operations
We consider assets to be held for sale when management approves and commits to a formal plan to actively market the assets for sale. Upon designation as held for sale, the carrying value of the assets are recorded at the lower of their carrying value or their estimated fair value, less costs to sell. We cease to record depreciation or amortization expense at that time. During the third quarter of 2006, we recorded an impairment charge of $8.6 million as events and circumstances indicated an impairment to our assets held for sale. Assets held for sale include certain non-core assets, particularly the generic dermatology business, dental business and related manufacturing facility of our subsidiary, QLT USA, Inc. in Fort Collins, Colorado. This amount was included in our loss from discontinued operations.
The results of operations for businesses that are classified as held for sale are excluded from continuing operations and reported as discontinued operations for the current and prior periods. Additionally, segment information does not include the results of businesses classified as discontinued operations. We do not expect any continuing involvement with these businesses following their sales and they are expected to be sold by early 2007.

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Revenue Recognition
Net Product Revenue
Our net product revenues are derived from sales of Visudyne® and Eligard®.
With respect to Visudyne, under the terms of our collaborative agreement with Novartis Ophthalmics, a division of Novartis Pharma AG, we are responsible for Visudyne manufacturing and product supply, and Novartis Ophthalmics is responsible for marketing and distribution of Visudyne. Our agreement with Novartis Ophthalmics provides that the calculation of total revenue from the sale of Visudyne be comprised of three components: (1) an advance on the cost of inventory sold to Novartis Ophthalmics, (2) an amount equal to 50% of Novartis Ophthalmics’ net proceeds from Visudyne sales (determined according to a contractually agreed definition) derived from the sale of Visudyne to end-users, and (3) the reimbursement of other specified costs incurred and paid for by us (See Note 8 — “Net Product Revenue”). We recognize revenue from the sale of Visudyne when persuasive evidence of an arrangement exists, delivery to Novartis Ophthalmics has occurred, the end selling price of Visudyne is fixed or determinable, and collectibility is reasonably assured. Under the calculation of revenue noted above, this occurs upon when Novartis Ophthalmics has sold Visudyne to its end customers.
With respect to Eligard, under the terms of the collaborative agreements with the commercial licensees of QLT USA, Inc., we are responsible for the manufacture of Eligard and receive from the commercial licensees an agreed upon sales price upon shipment to them. We also earn royalties from certain commercial licensees based upon their sales of Eligard products to end customers, which royalties are reported as net royalty revenue. We recognize net sales revenue from product sales when persuasive evidence of an arrangement exists, product is shipped and title is transferred to the commercial licensees, collectibility is reasonably assured and the price is fixed or determinable. QLT USA’s Eligard commercial licensees are responsible for all products after shipment from QLT USA’s facility. Under this calculation of revenue, we recognize net product revenue from Eligard at the time of shipment to the respective commercial licensees.
We do not offer rebates or discounts in the normal course of business and have not experienced any material product returns; accordingly, we do not provide an allowance for rebates, discounts, and returns.
Net Royalties
We recognize net royalties when product is shipped by certain commercial licensees to end customers based on royalty rates specified in our agreements with them. Generally, royalties are based on estimated net product sales (gross sales less discounts, allowances and other items) and calculated based on information supplied to us by the commercial licensees.
Contract Research and Development
Contract research and development revenues consist of non-refundable research and development funding under agreements with third parties with whom we have research or development relationships or licenses. Contract research and development funding generally compensates us for discovery, preclinical and clinical expenses related to the collaborative development programs for certain products and product candidates, and is recognized as revenue at the time research and development activities are performed under the terms of those agreements. For fixed price contracts, we recognize contract research and development revenue over the term of the agreement consistent with the pattern of work performed. Amounts received under those agreements for work actually performed are non-refundable even if the research and development efforts performed by us do not eventually result in a commercial product. Contract research and development revenues earned in excess of payments received are classified as contract research and development receivables and payments received in advance of revenue recognition are recorded as deferred revenue.

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         Licensing and Milestones
We have licensing agreements that generally provide for non-refundable license fees and/or milestone payments. The licensing agreements typically require a non-refundable license fee and allow our partners to sell our proprietary products in a defined territory for a defined period. A milestone payment is a payment made by a partner to us upon achievement of a pre-determined event, as defined in the applicable agreement. Non-refundable license fees and milestone payments are initially reported as deferred revenue. They are recognized as revenue over the remaining contractual term or as covered by patent protection, whichever is earlier, using the straight-line method or until the agreement is terminated. No milestone revenue is recognized until we have completed the required milestone-related services as set forth in licensing agreements.
Research and Development
Research and development costs are expensed as incurred and consist of direct and indirect expenditures, including a reasonable allocation of overhead expenses, associated with our various research and development programs. Overhead expenses comprise general and administrative support provided to the research and development programs and involve costs associated with support activities such as facility maintenance, utilities, office services, information technology, legal, accounting and human resources. Patent application, filing and defense costs are expensed as incurred. Research and development costs also include funding provided to third parties for joint research and development programs.
Stock-Based Compensation
On January 1, 2006, we adopted Statement of Financial Accounting Standard or SFAS 123 Revised, Share-Based Payment, or SFAS 123R using the modified prospective method. This statement eliminated the alternative to account for stock-based compensation using the intrinsic value method in accordance with the provisions of Accounting Principles Board (APB) Opinion No. 25, Accounting for Stock Issued to Employees. SFAS 123R requires such transactions be recognized as compensation expense in the statement of earnings based on their fair values on the date of the grant, with the compensation expense recognized over the period in which a grantee is required to provide service in exchange for the stock award. Compensation expense recognition provisions are applicable to new awards and to any awards modified, repurchased or cancelled after the adoption date. Additionally, for any unvested awards outstanding at the adoption date, we recognize compensation expense over the remaining service period using the compensation cost calculated for pro forma disclosure purposes under Statement of Financial Accounting Standard 123, Accounting for Stock-Based Payment, or SFAS123. As stock-based compensation expense recognized in the statement of income for the three and nine month periods ended September 30, 2006 is based on awards ultimately expected to vest, it has been reduced for estimated forfeitures. SFAS 123R requires forfeitures to be estimated at the time of grant and revised, if necessary, in subsequent periods if actual forfeitures differ from those estimates. Previously, in the pro forma information required under SFAS 123, we accounted for forfeitures as they occurred. Under the modified prospective application, prior periods are not revised for comparative purposes.
Impact of the Adoption of SFAS 123R
During the three and nine month periods ended September 30, 2006, we recorded stock-based compensation expense for awards granted prior to, but not yet vested, as of January 1, 2006, as if the fair value method required for pro forma disclosure under SFAS 123 was in effect for expense recognition purposes, adjusted for estimated forfeitures. For stock-based awards granted after January 1, 2006, we have recognized compensation expense based on the estimated grant date fair value method using the Black-Scholes valuation model, adjusted for estimated forfeitures. When estimating forfeitures, we consider voluntary termination behaviors as well as trends of actual option forfeitures.
The Black-Scholes option pricing model was developed for use in estimating the value of traded options that have no vesting restrictions and are fully transferable. In addition, option pricing models require the input of highly subjective assumptions including the expected stock price volatility. We project expected volatility and expected life of our stock options based upon historical and other economic data trended into future years. The risk-free interest rate assumption is based upon observed interest rates appropriate for the terms of our stock options.
The weighted average fair value of stock options granted during the three months ended September 30, 2006 was CAD $2.76, whereas the fair value of stock options granted in the three months ended September 30, 2005 was CAD $2.72. The weighted average fair value of stock options granted in the nine months ended September 30, 2006 was CAD $2.92 and U.S. $2.92 whereas the fair value of stock options granted in the nine months ended September 30, 2005 was CAD $4.23 and U.S. $4.00. We used the Black-Scholes option pricing model to estimate the value of the options at each grant date, using the following weighted average assumptions (no dividends are assumed):

9


 

                                 
    Three months ended   Nine months ended
    September 30,
2006
  September 30,
2005
  September 30,
2006
  September 30,
2005
 
Annualized volatility
    44.1 %     47.7 %     45.5 %     46.9 %
Risk-free interest rate
    3.8 %     3.4       4.2 %     3.4 %
Expected life (years)
    3.3       2.5       3.0       2.5  
 
The impact on our results of operations of recording stock-based compensation for the three-month and nine-month period ended September 30, 2006 was as follows:
                 
(In thousands of U.S. dollars, except share information)   Three months ended   Nine months ended
(Unaudited)   September 30, 2006   September 30, 2006
 
Cost of sales
  $ 15     $ 38  
Research and development
    598       1,866  
Selling, general and administrative
    335       1,003  
Discontinued operations
    85       233  
 
Share based compensation expense before income taxes
    1,033       3,140  
Related income tax benefits
           
 
Share based compensation, net of income taxes
  $ 1,033     $ 3,140  
 
 
               
Net share based compensation, per common share:
               
Basic
  $ 0.01     $ 0.04  
 
               
Diluted
  $ 0.01     $ 0.04  
 
Pro forma Information for Periods Prior to the Adoption of SFAS 123R
Prior to adopting the provisions of SFAS 123R, we accounted for our stock-based compensation under the intrinsic value method in accordance with the provisions of Accounting Principles Board (APB) Opinion No. 25, Accounting for Stock Issued to Employees, and provided the pro forma disclosures of net income and net income per share. Previously reported amounts have not been restated.
The following pro forma financial information presents the net income per common share had we recognized stock-based compensation using a fair value based accounting method:
                 
(In thousands of U.S. dollars except per share information)   Three months ended   Nine months ended
(Unaudited)   September 30, 2005   September 30, 2005
 
Net income
               
As reported
               
Less: Additional stock-based compensation expense under
  $ 12,899     $ 44,981  
the fair value method
    (1,818 )     (5,873 )
 
Pro forma
  $ 11,081     $ 39,108  
 
Basic net income per common share
               
As reported
  $ 0.14     $ 0.48  
Pro forma
    0.12       0.42  
 
Diluted net income per share
               
As reported
  $ 0.14     $ 0.47  
Pro forma
    0.12       0.42  
 
Net Income Per Common Share
Basic net income per common share is computed using the weighted average number of common shares outstanding during the period. Diluted net income per common share is computed in accordance with the treasury stock method and “if converted” method, as applicable, which uses the weighted average number of common shares outstanding during the period and also includes the dilutive effect of potentially issuable common stock from outstanding stock options, warrants and convertible debt. In addition, the related interest and amortization of deferred financing fees on

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convertible debt, when dilutive, (net of tax) are added back to income, since these would not be paid or incurred if the convertible senior notes were converted into common shares.
The following table sets out the computation of basic and diluted net income per common share:
                                 
    Three months ended   Nine months ended
(In thousands of U.S. dollars, except share and per share data)   September   September   September   September
(Unaudited)   30, 2006   30, 2005   30, 2006   30, 2005
 
Numerator:
                               
Income from continuing operations
  $ 6,195     $ 14,290     $ 27,090     $ 49,345  
Loss from discontinued operations, net of income taxes
    (9,941 )     (1,391 )     (11,219 )     (4,364 )
     
Net (loss) income
  $ (3,746 )   $ 12,899     $ 15,871     $ 44,981  
Effect of dilutive securities:
                               
Convertible senior notes — interest expense
                      4,020  
     
Adjusted (loss) income
  $ (3,746 )   $ 12,899     $ 15,871     $ 49,001  
     
Denominator:(thousands)
                               
Weighted average common shares outstanding
    83,831       92,637       87,734       92,979  
Effect of dilutive securities:
                               
Stock options
          282       51       621  
Convertible senior notes
                      9,693  
     
Diluted potential common shares
          282       51       10,314  
     
Diluted weighted average common shares outstanding
    83,831       92,919       87,785       103,293  
     
 
                               
Basic net (loss) income per common share
                               
Continuing operations
  $ 0.07     $ 0.15     $ 0.31     $ 0.53  
Discontinued operations
    (0.12 )     (0.02 )     (0.13 )     (0.05 )
     
Net (loss) income
  $ (0.04 )   $ 0.14     $ 0.18     $ 0.48  
     
 
                               
Diluted net (loss) income per common share
                               
Continuing operations
  $ 0.07     $ 0.15     $ 0.31     $ 0.52  
Discontinued operations
    (0.12 )     (0.02 )     (0.13 )     (0.04 )
     
Net (loss) income
  $ (0.04 )   $ 0.14     $ 0.18     $ 0.47  
     
Excluded from the calculation of diluted net income per common share for the three and nine months ended September 30, 2006 were 6,986,094 and 6,856,071 shares related to stock options because their effect was anti-dilutive. Also excluded were 9,692,637 shares related to the conversion of the $172.5 million 3% convertible senior notes because their effect was anti-dilutive. For the three months ended September 30, 2005, excluded from the calculation of diluted net income per common share were 8,949,135 shares related to stock options and 9,692,637 shares related to the conversion of the $172.5 million 3% convertible senior notes because their effect was anti-dilutive. For the nine months ended September 30, 2005, excluded from the calculation of diluted net income per common share were 7,940,976 shares related to stock options because their effect was anti-dilutive.
Recently Issued Accounting Standards
In March 2005, the FASB issued FIN 47, “Accounting for Conditional Asset Retirement Obligations—an interpretation of FASB Statement No. 143” (“FIN 47”). This Interpretation clarifies that the term conditional asset retirement obligation as used in FASB Statement No. 143, Accounting for Asset Retirement Obligations, refers to a legal obligation to perform an asset retirement activity in which the timing and (or) method of settlement are conditional on a future event that may or may not be within the control of the entity. An entity is required to recognize a liability for the fair value of a conditional asset retirement obligation if the fair value of the liability can be reasonably estimated. The fair value of a liability for the conditional asset retirement obligation should be recognized when incurred—generally upon acquisition, construction, or development and (or) through the normal operation of the asset. FIN 47 is effective for fiscal years ending after December 15, 2005. The adoption of FIN 47 did not have a material impact on our financial position or results of operations.
In May 2005, the FASB issued SFAS 154, “Accounting Changes and Error Corrections—a replacement of APB Opinion 20 and FASB Statement 3” (“SFAS 154”). This Statement replaces APB Opinion 20, “Accounting Changes” and FASB Statement 3, “Reporting Accounting Changes in Interim Financial Statements,” and changes the requirements for the accounting for and reporting of a change in accounting principle. SFAS 154 applies to all voluntary changes in an accounting principle. It also applies to changes required by an accounting pronouncement in the unusual instance that the pronouncement does not include specific transition provisions. When a pronouncement

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includes specific transition provisions, those provisions should be followed. SFAS 154 is effective for accounting changes and error corrections occurring in fiscal years beginning after December 15, 2005. The adoption of SFAS 154 did not have a material impact on our results of operations.
In February 2006, the FASB issued SFAS 155, “Accounting for Certain Hybrid Financial Instruments - an amendment of FASB statement 133 and 140 (“SFAS 155”). This Statement simplifies accounting for certain hybrid financial instruments by permitting fair value remeasurements for any hybrid financial instrument that contains an embedded derivative that would otherwise require bifurcation, and eliminates the restriction on the passive derivative instruments that a qualifying special purpose entity (SPE) may hold. This Statement is effective for all financial instruments acquired or issued after the beginning of an entity’s first fiscal year that begins after September 15, 2006. We believe the adoption of SFAS 155 will not have a material impact on our results of operations.
In July 2006, the FASB issued FIN 48 “Accounting for Uncertainty in Income Taxes — an interpretation of FASB Statement No. 109” (“FIN 48’). This interpretation provides guidance on the financial statement recognition and measurement of a tax position taken or expected to be taken in a tax return. FIN 48 also provides guidance on derecognition, classification, interest and penalties, accounting in interim periods, disclosures, and transition. FIN 48 is effective for fiscal years beginning after December 15, 2006. We are currently evaluating the impact of this standard on our Consolidated Financial Statements.
In September 2006, the FASB issued SFAS No. 157 “Fair Value Measurements” (“SFAS No. 157”) which defines fair value, establishes a framework for measuring fair value in generally accepted accounting principles, and expands disclosures about fair value measurements. This statement does not require any new fair value measurements and is effective for fiscal periods beginning after November 15, 2007. We are currently evaluating the impact of this standard on our Consolidated Financial Statements.
2. INVENTORIES
                 
(In thousands of U.S. dollars)   September 30, 2006   December 31, 2005
(Unaudited)                
Raw materials and supplies
  $ 13,812     $ 22,046  
Work-in-process
    26,625       29,083  
Finished goods
    954       390  
Provision for obsolete inventory
    (404 )     (1,452 )
Provision for non-completion of product inventory
    (5,535 )     (3,828 )
 
 
  $ 35,452     $ 46,239  
 
We record a provision for non-completion of product inventory to provide for the potential failure of inventory batches in production to pass quality inspection. During the three months ended September 30, 2006, we incurred charges of $0.1 million and $0.5 million to the provision for obsolete inventory and the provision for non-completion of product inventory respectively.
3. OTHER CURRENT ASSETS
                 
(In thousands of U.S. dollars)   September 30, 2006   December 31, 2005
(Unaudited)                
Visudyne inventory in transit held by Novartis Ophthalmics
  $ 13,813     $ 10,725  
Foreign exchange contracts
          5,015  
Prepaid expenses and other
    3,942       4,988  
 
 
  $ 17,755     $ 20,728  
 
Inventory in transit comprises finished goods that have been shipped to and are held by Novartis Ophthalmics. Under the terms of our collaborative agreement, upon delivery of inventory to Novartis Ophthalmics, we are entitled to an advance equal to our cost of inventory. The inventory in transit is also included in deferred revenue at cost, and will be recognized as revenue in the period of the related product sale and delivery by Novartis Ophthalmics to end customers, where collection is reasonably assured.

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Foreign exchange contracts consist of unrealized gains on foreign currency derivative financial instruments. At September 30, 2006, there are no unrealized gains on foreign currency derivative financial instruments. Unrealized losses on foreign currency derivative financial instruments are recorded in accrued liabilities (see Note 4 — Accrued Liabilities).
4. ACCRUED LIABILITIES
                 
(In thousands of U.S. dollars)   September 30, 2006   December 31, 2005
(Unaudited)                
Royalties
  $ 1,557     $ 2,654  
Compensation
    4,492       5,432  
Separation costs
    1,528       2,540  
Foreign exchange contracts
    1,284       2,172  
Interest
    408       1,740  
Other
    714       3,363  
 
 
  $ 9,983     $ 17,901  
 
5. CREDIT AND FOREIGN EXCHANGE FACILITIES
We have one credit facility and two foreign exchange facilities with three financial institutions for the sole purpose of entering into foreign exchange contracts.
The credit facility is secured by money market instruments equivalent to our credit limit of CAD $26.0 million that we deposited with the financial institution. We cannot draw on this credit facility as it serves as a pledge against our outstanding derivative contracts. As a result, interest charges are not applicable.
The two foreign exchange facilities have similar terms and allow us to enter into a maximum $550.0 million of forward foreign exchange contracts for terms up to 15 months, or in the case of spot foreign exchange transactions, a maximum limit of $95.0 million. These foreign exchange facilities are secured by money market instruments equivalent to our contingent credit exposure for the period in which any foreign exchange transactions are outstanding. At September 30, 2006, money market instruments totalling $7.8 million were pledged as security for these foreign exchange facilities. Interest charges, at the financial institutions’ prime rate plus 2%, are only applicable if we are in default with regards to the foreign exchange contracts.
6. RESTRUCTURING CHARGE
During the quarter ended March 31, 2005, we restructured our operations as a result of our acquisition of Atrix. We provided over 50 affected employees with severance and support to assist with outplacement (“First Restructuring”). As a result, we recorded $3.1 million of restructuring charges in 2005 related to severance and termination costs.
In December 2005, we restructured our operations in order to concentrate our resources on key product development programs and business initiatives (“Second Restructuring”). We provided approximately 100 affected employees with severance and support to assist with outplacement and recorded $5.0 million of restructuring charges. During the third quarter of 2006, we adjusted our restructuring accruals by an inconsequential amount to reflect current estimates related to this restructuring plan. We expect to complete final activities associated with this restructuring by early 2007.
On October 26, 2006, as a result of declining Visudyne sales, we announced plans to restructure our operations in order to reduce our overall cost basis going forward. The effect of this restructuring will be recorded in the fourth quarter of 2006. (See Note 14 — “Subsequent Event”)

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The details of our First and Second Restructurings are as follows:
Severance and termination benefits accrued
                         
(In thousands of U. S. dollars)   First
Restructuring
  Second
Restructuring
  Total
(Unaudited)                        
Balance at December 31, 2005
  $ 227     $ 4,499     $ 4,726  
Cash payments
    (140 )     (1,914 )     (2,054 )
 
Balance at March 31, 2006
  $ 87     $ 2,585     $ 2,672  
Adjustments
    (20 )     (253 )     (273 )
Cash payments
    (67 )     (892 )     (959 )
 
Balance at June 30, 2006
  $     $ 1,440     $ 1,440  
Adjustments
          24       24  
Cash payments
          (336 )     (336 )
 
Balance at September 30, 2006
  $     $ 1,128     $ 1,128  
 
 
Other related expenses accrued
 
(In thousands of U. S. dollars)   First
Restructuring
  Second
Restructuring
  Total
(Unaudited)                        
Balance at December 31, 2005
  $     $ 479     $ 479  
Adjustments
          52       52  
Cash payments
          (233 )     (233 )
 
Balance at March 31, 2006
  $     $ 298     $ 298  
Adjustments
          27       27  
Cash payments
          (164 )     (164 )
 
Balance at June 30, 2006
  $     $ 161     $ 161  
Adjustments
          (20 )     (20 )
Cash payments
          (14 )     (14 )
 
Balance at September 30, 2006
  $     $ 127     $ 127  
 
Combined Total
                         
(In thousands of U. S. dollars)   First
Restructuring
  Second
Restructuring
  Total
(Unaudited)                        
Balance at December 31, 2005
  $ 227     $ 4,978     $ 5,205  
Adjustments
          52       52  
Cash payments
    (140 )     (2,147 )     (2,287 )
 
Balance at March 31, 2006
  $ 87     $ 2,883     $ 2,970  
Adjustments
    (20 )     (226 )     (246 )
Cash payments
    (67 )     (1,056 )     (1,123 )
 
Balance at June 30, 2006
  $     $ 1,601     $ 1,601  
Adjustments
          4       4  
Cash payments
          (350 )     (350 )
 
Balance at September 30, 2006
  $     $ 1,255     $ 1,255  
 

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7. SHARE CAPITAL
(a)   Share Repurchase
 
    On April 28, 2005, we announced a share buy-back program pursuant to which we could purchase up to $50.0 million of our common shares over a two-year period. In December 2005 we increased the amount that could be purchased to $100.0 million of our common shares over a two-year period ending May 2007. The share purchases were made as a normal course issuer bid and were effected in the open market through the facilities of The Toronto Stock Exchange and the NASDAQ Stock Market, and in accordance with all regulatory requirements. Cumulative purchases under this program since May 2005 were 6,264,400 common shares at an average price of $8.20, for a total cost of $51.3 million. On July 27, 2006, we terminated this normal course issuer bid as a result of our decision to proceed with an offer to purchase up to 13 million common shares in a modified “Dutch Auction” tender offer. Under this “Dutch Auction” tender offer, shareholders were invited to tender all or a portion of their shares at a price per share that was not less than US$7.00 and not greater than US$8.00. Based on the number of shares tendered and the prices specified by the tendering shareholders, we determined the lowest price per share within the range that allowed us to buy 13 million shares properly tendered. The tender offer commenced on August 3, 2006 and expired on September 8, 2006. As a result of this tender offer, we accepted for purchase and cancellation 13 million common shares at a price of $8.00 per share, totaling $104 million. These shares represented approximately 14.7% of the shares outstanding as of September 8, 2006. Our total outstanding common shares on September 30, 2006 were 75,170,300 shares.
 
    In repurchasing our common shares under the normal course issuer bid described above, the prices we paid for the shares we repurchased were different than our carrying value for these shares. We had previously recorded this difference between purchase price and carrying value in the accumulated deficit section of our shareholders’ equity. We have made adjustments to prior periods to record the amounts representing the excess of carrying value over the purchase price of the shares as additional paid-in capital. As a result, our December 31, 2005 additional paid-in capital increased by $6.2 million and correspondingly, our accumulated deficit increased by $6.2 million. This adjustment had no impact on previously reported results of operations or cashflows and was not material to the balance sheet.
 
(b)   Stock Options
 
    Stock option activity with respect to our 1998 Plan and 2000 Plan is presented below:
                         
                    Aggregate
            Exercise Price   intrinsic value
(In Canadian dollars)   Number of Options   Per Share Range   (in millions)
(Unaudited)                        
Outstanding at December 31, 2005
    5,469,850     $ 7.79 - $108.60          
Granted
    1,479,876     $ 7.79 - $    9.22          
Exercised
    1,778       $    7.79          
Cancelled
    3,164,551     $ 7.79 - $108.60          
 
 
                       
Outstanding at September 30, 2006
    3,783,397     $ 7.79 - $37.15     $ 0.4  
 
                       
Exerciseable at September 30, 2006
                  $ 0.1  
 

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    Stock option activity with respect to all our other option plans is presented below:
                         
                    Aggregate
            Exercise Price   intrinsic value
(In U.S. dollars)   Number of Options   Per Share Range   (in millions)
(Unaudited)                        
Outstanding at December 31, 2005
    4,184,499     $ 2.89 - $17.82          
Granted
    222,625     $ 7.27 - $  8.31          
Exercised
    106,841     $ 2.89 - $  7.88          
Cancelled
    1,097,586     $ 5.85 - $17.82          
 
 
                       
Outstanding at September 30, 2006
    3,202,697     $ 2.89 - $17.82     $ 0.5  
 
                       
Exercisable at September 30, 2006
                  $ 0.3  
 
    Additional information relating to stock options outstanding under the 1998 Plan and the 2000 Plan as of September 30, 2006, is presented below:
                                         
(In Canadian dollars)   Options Outstanding   Options Exercisable
(Unaudited)                   Weighted            
                    Average            
            Weighted   Remaining           Weighted
            Average   Contractual   Number of   Average Exercise
Price Range   Number of Options   Exercise Price   Life (Years)   Options   Price
 
Under $12.50
    2,080,905     $ 8.52       4.26       519,860     $ 8.92  
$12.51 - $17.50
    866,093       14.45       2.61       620,353       14.22  
$17.51 - $30.00
    359,757       23.14       0.85       346,759       23.22  
$30.01 - $37.15
    476,642       32.85       2.43       396,157       32.87  
 
 
    3,783,397                       1,883,129          
 
    Additional information relating to stock options outstanding under all other stock option plans as of September 30, 2006, is presented below:
                                         
(In U.S. dollars)   Options Outstanding   Options Exercisable
(Unaudited)                   Weighted            
                    Average            
            Weighted   Remaining           Weighted
    Number of   Average   Contractual   Number of   Average Exercise
Price Range   Options   Exercise Price   Life (Years)   Options   Price
 
Under $7.50
    337,947     $ 6.22       3.80       178,548     $ 5.65  
$7.51 - $10.00
    677,951       8.60       5.03       548,235       8.67  
$10.01 - $12.50
    808,062       11.79       5.30       683,562       11.68  
$12.51 - $16.00
    410,637       13.85       6.07       410,637       13.85  
$16.01 - $17.82
    968,100       16.33       7.69       968,100       16.33  
 
 
    3,202,697                       2,789,082          
 
    At September 30, 2006, total unrecognized estimated compensation cost related to non-vested stock options granted prior to that date was $7.3 million, which is expected to be recognized over 36 months with a weighted-average period of 2.0 years. The total share-based compensation cost of stock options capitalized as part of inventory was $0.1 million and $0.3 million during the three and nine month periods ended September 30, 2006. The total intrinsic value of stock options exercised during the three months and nine month periods ended September 30, 2006 was $0.1 million and $0.2 million, respectively. For the three and nine month periods ended September 30, 2006, we recorded cash received from the exercise of stock options of $0.1 million and $0.7 million, respectively and there were no related tax benefits recorded during these same periods. Upon option exercise, we issue new shares of stock.

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8.   NET PRODUCT REVENUE
Net product revenue was determined as follows:
                                 
    For the three months ended   For the nine months ended
    September 30,   September 30,
(In thousands of U.S. dollars)   2006   2005   2006   2005
(Unaudited)                                
Visudyne® sales by Novartis Ophthalmics
  $ 75,137     $ 123,733     $ 277,259     $ 376,521  
Less: Marketing and distribution costs
    (32,289 )     (32,497 )     (96,796 )     (104,653 )
Less: Inventory costs
    (3,963 )     (5,104 )     (14,669 )     (18,601 )
Less: Royalties to third parties
    (1,581 )     (2,757 )     (5,942 )     (8,371 )
 
 
  $ 37,304     $ 83,375     $ 159,852     $ 244,896  
 
 
                               
QLT’s 50% share of Novartis Ophthalmics’ net proceeds from Visudyne sales
  $ 18,652     $ 41,688     $ 79,926     $ 122,448  
Add: Advance on inventory costs from Novartis Opthalmics
    3,153       4,353       11,922       14,495  
Add: Royalties reimbursed to QLT
    1,552       2,656       5,944       8,103  
Add: Other costs reimbursed to QLT
    2,406       1,242       4,393       3,597  
 
Revenue from Visudyne® sales
  $ 25,763     $ 49,939     $ 102,185     $ 148,643  
 
                               
Net product revenue from Eligard® and other products (see Note 12)
    5,846       5,953       17,643       13,231  
 
 
  $ 31,609     $ 55,892     $ 119,828     $ 161,874  
 
For the three months ended September 30, 2006, approximately 15% of total Visudyne sales were in the United States, with Europe and other markets responsible for the remaining 85%. For the same period in 2005, approximately 41% of total Visudyne sales by Novartis Ophthalmics were in the United States with Europe and other markets responsible for the remaining 59%.
For the nine months ended September 30, 2006, approximately 22% of total Visudyne sales by Novartis Ophthalmics were in the United States with Europe and other markets responsible for the remaining 78%. For the same period in 2005, approximately 40% of total Visudyne sales by Novartis Ophthalmics were in the United States with Europe and other markets responsible for the remaining 60%.
9. DISCONTINUED OPERATIONS
To focus our business on the research and development of proprietary products in our core therapeutic areas, during the first quarter of 2006, we initiated an active plan for the sale of certain non-core assets, including the generic dermatology business, dental business and related manufacturing facility of QLT USA, Inc. in Fort Collins, Colorado. In accordance with SFAS No. 144, “Accounting for the Impairment or Disposal of Long-lived Assets”, the generic dermatology and dental businesses were accounted for as discontinued operations. Accordingly, the results of operations of these businesses have been excluded from continuing operations and reported as discontinued operations for the current and prior periods. In addition, the assets included as part of this divestiture have been reclassified as held for sale in the Consolidated Balance Sheet. During the third quarter of 2006, we recorded an impairment charge of $8.6 million as events and circumstances indicated an impairment to our assets held for sale. The primary indicators of impairment were the failure to receive approval for a late stage generic dermatology product, as well as a launch delay for another product. We measured the impairment loss based on the amount by which the carrying value of the assets exceeded their fair value less cost to sell. Our measurement of fair value was based on future discounted cash flows.
The carrying values of these assets are summarized as follows:

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(In thousands of U.S. dollars)   September 30,
2006
  December 31,
2005
(Unaudited)                
Property, plant and equipment
  $ 17,009     $ 22,700  
Intangible assets
    4,920       6,926  
 
 
  $ 21,929     $ 29,626  
 
Operating results of our generic dermatology and dental businesses included in discontinued operations are summarized as follows:
                                 
    For the three months ended   For the nine months ended
    September 30,   September 30,
(In thousands of U.S. dollars)   2006   2005   2006   2005
(Unaudited)                                
Net revenue
  $ 2,600     $ 3,045     $ 10,505     $ 9,137  
 
 
Impairment of assets held for sale
    (8,592 )           (8,592 )      
 
 
Pretax losses
    (10,970 )     (1,563 )     (12,312 )     (4,911 )
Income taxes
    1,029       172       1,093       549  
 
Net loss from discontinued operations
  $ (9,941 )   $ (1,391 )   $ (11,219 )   $ (4,362 )
 
10. FINANCIAL INSTRUMENTS AND CONCENTRATION OF CREDIT RISK
As at September 30, 2006 and December 31, 2005, the carrying amounts for our cash and cash equivalents, short-term investment securities, restricted cash, accounts receivable, and accounts payable approximated fair value due to the short-term maturity of these financial instruments. Our investment in common shares of Diomed Holdings Inc. is carried at fair value based on quoted market prices. Our long-term debt comprises $172.5 million aggregate principal amount of convertible senior notes which had a fair value of $161.7 million as of September 30, 2006 as published by an independent investment bank. These notes are not listed on any securities exchange or included in any automated quotation system. The published value may not be reliable as the amounts cannot be independently verified and not all trades are reflected.
With respect to the concentration of credit risk, our accounts receivable, as at September 30, 2006 and December 31, 2005, comprised primarily of amounts owing from Novartis Pharma AG.
We purchase goods and services primarily in Canadian (“CAD”) and U.S. dollars (“USD”), and earn most of our revenues in USD and Euros (“EUR”). We enter into foreign exchange contracts to manage exposure to currency rate fluctuations related to our expected future net income (primarily in USD and EUR) and cash flows (in USD and Swiss francs (“CHF”)). We are exposed to credit risk in the event of non-performance by counterparties in connection with these foreign exchange contracts. We mitigate this risk by transacting with a diverse group of financially sound counterparties and, accordingly, do not anticipate loss for non-performance. Foreign exchange risk is also managed by satisfying foreign denominated expenditures with cash flows or assets denominated in the same currency. The net unrealized loss in respect of such foreign currency contracts, as at September 30, 2006, was approximately $0.5 million, which was included in our results of operations. At September 30, 2006, we have outstanding forward foreign currency contracts as noted below.
                         
(Unaudited)   Maturity Period   Quantity (millions)   Average Price
 
U.S. / Canadian dollar option-dated forward contracts
    2006- 2007     USD 7.6   1.18514 per USD
 
                       
Swiss franc / Canadian dollar option-dated forward contracts
    2006 - 2007     CHF 59.4   0.90296 per CHF
 
                       
Canadian dollar / Swiss franc average rate forward contract
    2006     CAD 3.8   0.90590 per CHF
 
                       

18


 

                         
(Unaudited)   Maturity Period   Quantity (millions)   Average Price
Canadian / U.S. dollar average rate forward contract
    2006     CAD 18.2   1.15973 per USD
 
                       
Australian dollar (AUD) / Swiss franc average rate forward contract
    2006     AUD 2.1   0.93180 per AUD
 
                       
Euro / Swiss franc average rate forward contract
    2006     EUR 10.7   1.53121 per EUR
 
                       
U.S. dollar / Swiss franc average rate forward contract
    2006     USD 0.4   1.26880 per USD
 
                       
Great Britain pound (GBP) / Swiss franc average rate forward contract
    2006     GBP 1.1   2.22280 per GBP
 
                       
Japanese yen (JPY) / Swiss franc average rate forward contract
    2006     JPY 185.6   0.01112 per JPY
 
11. SEGMENTED INFORMATION
We operate in one industry segment, which is the business of developing, manufacturing, and commercializing therapeutics for human health care. Our chief operating decision makers review our operating results on an aggregate basis and manage our operations as a single operating segment. Our segment information does not include the results of businesses classified as discontinued operations.
Details of our revenues by product category are as follows:
                                 
    For the three months ended   For the nine months ended
    September 30,   September 30,
(In thousands of U.S. dollars)   2006   2005   2006   2005
(Unaudited)                                
Net product revenue and royalties
                               
Visudyne®
  $ 25,763     $ 49,938     $ 102,184     $ 148,642  
Eligard®
    11,645       9,539       31,629       24,014  
Other
    319       294       963       710  
Contract research and development
    275       1,170       946       8,583  
Licensing and milestones
    244       189       732       502  
 
 
  $ 38,246     $ 61,130     $ 136,454     $ 182,451  
 

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Details of our revenues and property, plant and equipment by geographic segments are as follows:
                                 
    For the three months ended   For the nine months ended
Revenues   September 30,   September 30,
(In thousands of U.S. dollars)   2006   2005   2006   2005
(Unaudited)                                
United States
  $ 11,232     $ 27,783     $ 43,264     $ 86,684  
Europe
    19,820       23,462       64,481       67,105  
Canada
    3,581       4,122       13,555       11,904  
Other
    3,613       5,763       15,154       16,758  
 
 
  $ 38,246     $ 61,130     $ 136,454     $ 182,451  
 
 
Property, plant and equipment   September   December                
(In thousands of U.S. dollars)   30, 2006   31,2005                
(Unaudited)                                
Canada
  $ 48,412     $ 48,378                  
United States
    4,083       4,419                  
 
 
  $ 52,495     $ 52,797                  
 
Revenues are attributable to a geographic segment based on the location of: (a) the customer, for net product revenue and royalties; and (b) the head office of the collaborative partner, in the case of revenues from contract research and development and collaborative arrangements.
12. CONTINGENCIES
(a) TAP Litigation
United States
In 2003, plaintiffs TAP Pharmaceutical Products, Inc., Takeda Chemical Industries Ltd. and Wako Pure Chemical Industries, Ltd. filed suit against our subsidiary, QLT USA, Inc. (formerly Atrix Laboratories, Inc.) and co-defendant Sanofi-Synthelabo, Inc. in the U.S. federal court in the Northern District of Illinois Eastern Division (Case No. 1:03-CV-7822). TAP and its co-plaintiffs allege that QLT USA and Sanofi-Synthelabo willfully infringed U.S. Patent No. 4,728,721 (the “‘721 patent”) by the manufacture and sale in the United States of the Eligard® product line and seek injunctive relief, damages, and an award of attorneys’ fees and costs against QLT USA and Sanofi-Synthelabo. The ‘721 patent expired on May 1, 2006.
In its amended answer to the claim, QLT USA and Sanofi-Synthelabo denied the material allegations of the complaint and asserted that the ‘721 patent is invalid, unenforceable, and not infringed. QLT USA and Sanofi-Synthelabo also asserted a counterclaim for declaratory judgements of invalidity, unenforceability, and non-infringement. In December 2005, the case went to trial on liability issues. In the trial, QLT USA and Sanofi-Synthelabo did not contest infringement of the asserted claims of the patent-in-suit as they were construed by the district judge. A jury rendered verdicts that QLT USA and Sanofi-Synthelabo had not proved, by clear and convincing evidence, that the asserted claims were invalid. Thereafter, the judge issued findings of fact rejecting the defendants’ unenforceability defense. On January 24, 2006, the district court entered judgement for TAP and its co-plaintiffs on the invalidity and unenforceability defenses.
In February 2006, plaintiffs filed a motion with the district court seeking an injunction. On February 27, the district court granted an injunction, subject to a seven day stay, enjoining us, sanofi-aventis and subsidiaries from promoting, manufacturing, selling and offering for sale Eligard products in the United States until May 1, 2006, the expiration date of the ‘721 patent. The Court further ordered QLT USA and sanofi-aventis to recall any Eligard products that they still own and provide a voluntary recall program to allow physicians, wholesalers and distributors, who wish to do so, to return Eligard products for a full refund.
On February 28, 2006, QLT USA and Sanofi-Synthelabo filed notices of appeal, as well as emergency motions in the Court of Appeals for the Federal Circuit seeking a stay of the injunction pending the outcome of the appeal. The Court of Appeals issued an order temporarily staying the injunction and then on March 30, 2006, the Court of Appeals

20


 

granted a permanent stay of the injunction, subject to an escrow of QLT USA and Sanofi-Synthelabo’s net revenues from Eligard sales during the period from February 27 to May 1, 2006 which was determined to be $1.7 million and is recorded as restricted cash on our consolidated balance sheet. Sanofi-Synthelabo had previously announced that it was discontinuing sales of Eligard in the U.S. until the expiry of the patent. However, as a result of the Court of Appeals’ decision and its reasoning in granting a permanent stay of the injunction, in early April 2006 Sanofi-Synthelabo re-launched Eligard in a limited manner in order to serve the interests of public health.
Earlier in the case, the issues of damages and willful infringement were separated from the trial on liability. A trial date of January 29, 2007 has been scheduled for the damages and willfulness phase of the case. In the meantime, the parties are proceeding with fact discovery on the damages and willfulness issues.
On September 8, 2006, the Court of Appeals heard our appeal from the district court’s judgement of liability. A decision from the Court of Appeal is anticipated before the end of the year.
Under the agreement entered into between QLT USA and Sanofi-Synthelabo, QLT USA has provided certain indemnities to Sanofi-Synthelabo and its affiliates, including indemnities covering certain losses relating to infringement of a third party’s proprietary rights on and subject to the terms of that agreement.
Germany
On June 1, 2004, our Eligard marketing collaborator, MediGene AG, filed an action in the Federal Patent Court, Munich, Germany, seeking nullification of the European equivalent to the ‘721 patent, European Patent 0 202 065 (the “’065 patent”). The ‘065 patent expired on May 6, 2006.
On June 21, 2004, Takeda Chemical Industries Ltd., Wako Pure Chemical Industries, Ltd. and Takeda Pharma GmbH sought a provisional injunction in the Regional Court Hamburg, Germany, alleging that the marketing of Eligard by MediGene and its licensee Yamanouchi (now Astellas) in Germany violated the ‘065 patent. The Court denied that request.
On June 28, 2004, the Takeda companies and Wako filed a complaint in the Regional Court Düsseldorf, Germany, against MediGene and Yamanouchi, alleging infringement of the ‘065 patent.
In April 2005, in the suit initiated by MediGene, the Federal Patent Court ruled that all of the patent claims asserted by the Takeda companies and Wako in their subsequent infringement suit are null and void in Germany for lack of novelty and lack of inventive step. Takeda and Wako have appealed that decision. The Regional Court Düsseldorf has stayed the infringement action brought by Takeda and Wako in view of the Federal Patent Court’s decision.
Under agreements QLT USA entered into with MediGene and Yamanouchi, QLT USA has provided certain indemnities to MediGene and Yamanouchi including indemnities covering certain losses relating to infringement of a third party’s proprietary rights on and subject to the terms of that agreement.
(b) Patent Litigation with MEEI
The First MEEI Lawsuit
In April 2000, Massachusetts Eye and Ear Infirmary (“MEEI”) filed a civil suit against QLT Inc. in the United States District Court (the “Court”) for the District of Massachusetts seeking to establish exclusive rights for MEEI as the owner of certain inventions relating to the use of verteporfin (the active pharmaceutical ingredient in Visudyne®) as the photoactive agent in the treatment of certain eye diseases including AMD.
In 2002, we moved for summary judgement against MEEI on all eight counts of MEEI’s complaint in Civil Action No. 00-10783-JLT. The Court granted our motion, dismissing all of MEEI’s claims. With respect to our counterclaim requesting correction of inventorship of U.S. Patent No. 5,789,349 (the “‘349 patent”) to add an additional Massachusetts General Hospital (“MGH”) inventor, the Court stayed the claim pending the outcome of the appeal described below.
MEEI appealed the decision of the Court to the U.S. Court of Appeals for the First Circuit. In a decision dated June 15, 2005, the Court of Appeals upheld the dismissal of five of MEEI’s eight claims and remanded to the district court for further proceedings concerning three of MEEI’s claims (unjust enrichment, unfair trade practices and misappropriation of trade secrets). In February, 2006 we filed a Petition for Writ of Certiorari in the United States Supreme Court

21


 

asserting that MEEI’s claim for unjust enrichment is preempted by federal patent law. The Court of Appeals stayed its remand to the district court pending the resolution of our Petition by the Supreme Court. In May 2006, the Supreme Court denied our Petition, and MEEI’s three remaining claims were then remanded to the district court for further proceedings.
On November 6, 2006, a federal jury found QLT liable under Massachusetts state law for unjust enrichment and unfair trade practices and determined that we should pay to MEEI a royalty of 3.01% on net sales of Visudyne worldwide. It remains for the court to determine whether this relates to future sales, or past and future sales of Visudyne. The trial judge will now consider post-trial motions including whether the decision of the jury is of an advisory nature. From the time Visudyne was launched in 2000 to September 30, 2006, net sales of Visudyne have totaled approximately $2.2 billion worldwide. The jury determined that the unfair trade practices were not committed knowingly or willfully and therefore declined to award enhanced damages. Any award may include interest at court imposed rates and MEEI’s attorneys’ fees. We expect to present post-trial motions addressing the effect of the jury’s verdict and to continue to vigorously pursue the defense of this case. It is uncertain when final judgment will be entered.
The Second MEEI Lawsuit
In May 2001 the United States Patent Office issued United States Patent No. 6,225,303 (the “’303 Patent”) to MEEI. The ‘303 Patent is derived from the same patent family as the Patent in issue in the first suit, the ‘349 patent, and claims a method of treating unwanted choroidal neovasculature in a shortened treatment time using verteporfin (the active pharmaceutical ingredient in Visudyne®). The patent application which led to the issuance of the ‘303 patent was filed and prosecuted by attorneys for MEEI and, in contrast to the ’349 patent, named only MEEI researchers as inventors.
The same day the ‘303 patent was issued, MEEI commenced a second civil suit against us and Novartis Ophthalmics, Inc. (now Novartis Ophthalmics, a division of Novartis Pharma AG) in the United States District Court for the District of Massachusetts alleging infringement of the ‘303 Patent (Civil Action No. 01-10747-EFH). The suit seeks damages and injunctive relief for patent infringement. We have answered the complaint, denying its material allegations and raising a number of affirmative defenses, including incorrect inventorship, and we have asserted counterclaims against MEEI and the two MEEI researchers who are named as inventors on the ‘303 patent. In addition, MGH has intervened in the case requesting correction of inventorship on the ‘303 patent to add three MGH scientists and one QLT scientist as joint inventors of the claimed inventions.
In 2004, we and MGH moved to correct inventorship on the ‘303 patent. In January 2005, the Court granted partial summary judgement ordering that the ‘303 patent be corrected to add QLT’s scientist as a joint inventor. Because the Court’s partial ruling made QLT a co-owner of the patent, the Court dismissed MEEI’s complaint for infringement. MEEI appealed that decision to the Court of Appeals for the Federal Circuit. In early October, 2006, the Court of Appeals for the Federal Circuit overturned that summary judgement on the basis that there are issues of fact that remain to be determined. The case has been remanded to the district court for further proceedings. We expect the judge at the district court will now decide whether to rule on the remaining and previously undecided summary judgement motions brought by QLT and MGH with respect to their inventorship on the patent. A trial has now been scheduled for March 2007.
The district court has not yet ruled on whether MGH’s scientists should be added to the patent as joint inventors, nor has it ruled on certain additional grounds we asserted for adding our scientist as an inventor. The Court stayed further proceedings on these issues pending the outcome of MEEI’s appeal. An eventual ruling in our favor on any of these issues would defeat MEEI’s infringement suit, either because the ruling would confirm our status as a co-owner of the patent or because the ruling would make MGH a co-owner of the patent and we would be entitled to assert MGH’s co-ownership rights under a license agreement we have entered into with MGH.
The ‘349 patent is co-owned by QLT, MGH and MEEI. QLT entered into an exclusive license with MGH for its rights under the ‘349 patent in return for a royalty equal to 0.5% of net sales of Visudyne in the United States and Canada. Under the license agreement with MGH, if QLT concludes a license agreement with MEEI for rights under the ‘349 patent and continuation patents which includes payment of royalties and other compensation to MEEI that are more favorable than are contained in the license agreement with MGH, then as of the effective date of such more favorable royalties or compensation to MEEI, the license agreement with MGH shall be revised to the same rate as paid under the agreement with MEEI.
(c) Effect of the TAP Litigation and MEEI Litigation
The final outcome of the TAP and MEEI litigation is not presently determinable or estimable and accordingly, no amounts have been accrued. There can be no assurance that the matters will finally be resolved in our favor. If the TAP litigation is not resolved favorably, QLT USA could be found liable for damages. If the MEEI litigation is not resolved favorably, QLT could be liable for damages or injunctive relief. While we cannot estimate the potential damages in the TAP and MEEI litigation, or what level of indemnification by QLT USA, if any, will be required in connection with the TAP litigation under the agreements with either Sanofi-Synthelabo or MediGene and Yamanouchi (now Astellas), the amount of damages and indemnification could be substantial, which could have a material adverse impact on our financial condition. Alternatively, the TAP and/or MEEI litigation could be resolved favorably or could be settled. An outcome could materially affect the market price of our shares, either positively or negatively. We will continue to aggressively pursue the TAP and MEEI litigation, and potential settlement discussions.
13. RECONCILIATION FROM U.S. GAAP TO CANADIAN GAAP
Canadian securities regulations allow issuers that are required to file reports with the United States Securities & Exchange Commission, or SEC, upon meeting certain conditions, to satisfy their Canadian continuous disclosure obligations by using financial statements prepared in accordance with U.S. GAAP. Accordingly, for interim periods in fiscal 2006, we will include in the notes to our consolidated financial statements a reconciliation highlighting the material differences between our financial statements prepared in accordance with U.S. GAAP as compared to

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financial statements prepared in accordance with accounting principles generally accepted in Canada (“Canadian GAAP”). Subsequent to 2006, no further interim reconciliation will be required under current Canadian securities regulations. Prior to 2005, we prepared interim financial statements (with accompanying notes) and Management’s Discussion and Analysis — Canadian Supplement in accordance with Canadian GAAP, all of which were presented as a separate report and filed with the relevant Canadian securities regulators in compliance with our Canadian continuous disclosure obligations.
Our consolidated financial statements have been prepared in accordance with U.S. GAAP and the accounting rules and regulations of the SEC which differ in certain material respects from those principles and practices that we would have followed had our consolidated financial statements been prepared in accordance with Canadian GAAP. The following is a reconciliation of our net income as reported in U.S. GAAP and our net income computed in accordance with Canadian GAAP for the three and nine months ended September 30, 2006 and 2005.
                                 
    For the three months ended   For the nine months ended
    September 30,   September 30,
(In thousands of U.S. dollars, except per share amounts)   2006   2005   2006   2005
Net income, U.S. GAAP
  $ (3,746 )   $ 12,899     $ 15,871     $ 44,981  
Stock based compensation charge (a)
          (1,818 )           (5,873 )
Amortization of in-process research and development (b)
    (1,320 )     (3,471 )     (3,960 )     (10,412 )
FIT recovery on amortization of in-process research and development (b)
    502       1,319       1,505       3,956  
Imputed interest on convertible debt (c)
    (2,027 )     (1,892 )     (6,023 )     (5,501 )
Unrealized foreign exchange gain (loss) on convertible debt (c)
    405       (795 )     449       12  
License and option fees (d)
                1,910        
Amortization of license and option fees (d)
    (27 )           (49 )      
Goodwill impairment charge
          (230,000 )           (230,000 )
Provision for (recovery of) income taxes on above items (b), (f)
    (163 )     327       (452 )     184  
     
Net (loss) income, Canadian GAAP
  $ (6,377 )   $ (223,431 )   $ 9,251     $ (202,653 )
     
 
                               
Basic net (loss) income per common share, Canadian GAAP
  $ (0.08 )   $ (2.41 )   $ 0.11     $ (2.18 )
 
                               
Diluted net (loss) income per common share
  $ (0.08 )   $ (2.41 )   $ 0.11     $ (2.18 )
 
                               
Weighted average number of common shares outstanding (in thousands)
                               
Basic
    83,831       92,637       87,734       92,979  
Diluted
    83,831       92,637       87,785       92,979  
The following is a reconciliation of our balance sheet information as reported in U.S. GAAP and our balance sheet information computed in accordance with Canadian GAAP as of September 30, 2006 and December 31, 2005.

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(In thousands of U.S. dollars)   September 30, 2006   December 31, 2005
(Unaudited)                
Total assets under U.S. GAAP
  $ 648,316     $ 776,494  
Short-term investments (g)
          137  
Intangibles, net (b), (d), (e)
    81,788       83,880  
Goodwill (b), (e)
    41,923       41,923  
Other long-term assets (g)
          313  
 
Total assets under Canadian GAAP
  $ 772,027     $ 902,747  
 
 
               
Total liabilities under U.S. GAAP
  $ 220,711     $ 250,383  
Future income tax liabilities (b), (f)
    30,218       31,289  
Long-term debt (c)
    (12,906 )     (17,848 )
 
Total liabilities under Canadian GAAP
  $ 238,023     $ 263,824  
 
 
               
Total shareholders’ equity under U.S. GAAP
  $ 427,605     $ 526,111  
Common shares (a), (g), (h), (i)
    (2,434 )     (2,434 )
Contributed surplus (a)
    59,000       59,000  
Equity component of convertible debt (c)
    33,500       33,500  
(Deficit) Retained earnings (j)
    10,140       16,758  
Cumulative translation adjustment(k)
    6,193       5,988  
 
Total shareholder’s equity under Canadian GAAP
  $ 534,004     $ 638,923  
 
 
(a)   Effective January 1, 2004, we adopted the fair value method of accounting for all employee and non-employee stock-based compensation for Canadian GAAP purposes on a retroactive basis, without restatement of prior periods. Compensation expense is recorded for stock options issued to employees using the fair value method. Under U.S. GAAP, we adopted SFAS 123R for stock options granted to employees and directors on January 1, 2006, using the modified prospective method, resulting in no difference in net income between U.S. GAAP and Canadian GAAP for the three and nine months ended September 30, 2006.
 
(b)   Under Canadian GAAP, acquired in-process research and development (“IPR&D”) projects are recorded as an intangible asset and amortized over their useful life. On November 19, 2004, we acquired IPR&D of $236.0 million through the acquisition of Atrix Laboratories, Inc. Accordingly, this amount was capitalized for Canadian GAAP purposes and is being amortized using the straight-line method over its useful life of seventeen years. As a result of book-tax basis differences attributable to IPR&D, an additional deferred tax liability of $89.7 million was recorded. During the quarter ended September 30, 2006, the future income tax liability was adjusted by $0.5 million for Canadian GAAP purposes to reflect the reduction in the temporary difference due to the amortization of the IPR&D. Under U.S. GAAP, IPR&D is expensed at time of acquisition. As a result of the impairment charge during 2005, amortization of IPR&D was lower for the three and nine months ended September 30, 2006. In addition, the future income tax liability was reduced by $91.8 million under Canadian GAAP ($39.9 million under U.S. GAAP). See note (e) for further discussion on the impairment charge.
 
(c)   In 2003, we completed a private placement of $172.5 million aggregate principal amount of convertible senior notes. Under Canadian GAAP, an amount of $33.5 million, representing the estimated value of the right of conversion, was allocated to the shareholders’ equity as the equity component of the convertible debt. Furthermore, with bifurcation, accretion expense is recorded as interest expense under Canadian GAAP. Under U.S. GAAP, bifurcation of debt is not required. In addition, foreign exchange gains/losses are calculated for the full face value of the debt under U.S. GAAP, and calculated only on the liability component under Canadian GAAP.
 
(d)   During the nine months ended September 30, 2006, we acquired certain license and option rights. Under U.S. GAAP, technology licenses and options may not have alternative future uses and were therefore expensed as research and development costs. Under Canadian GAAP, the license and option rights were capitalized as intangibles and are amortized over their useful lives of 17 — 18 years.
 
(e)   During 2005, we performed impairment tests for goodwill and other intangibles and recorded, under U.S. and Canadian GAAP, non-cash impairment charges of $410.5 million and $594.9 million, respectively. The charge reduced the Canadian GAAP carrying amount of goodwill to $145.9 million. Under U.S. GAAP, as explained in (b) above, we expensed IPR&D at the time of acquisition which had the effect of lowering the carrying value of the assets we acquired from Atrix as compared to Canadian GAAP. Under Canadian GAAP, as explained in (b)

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    above, we capitalized IPR&D at the time of acquisition, which increased the carrying value of the assets we acquired from Atrix as compared to US GAAP. With the higher carrying value, impairment of goodwill and other intangibles was higher under Canadian GAAP than under US GAAP.
 
(f)   The differences between Canadian GAAP and U.S. GAAP assets and liabilities resulted in different deferred tax assets and deferred tax liabilities under the respective GAAP’s. Furthermore, investment tax credits are calculated using different formulas for Canadian and U.S. GAAP purposes due to different forecasted earnings under the respective GAAP’s. Under U.S. GAAP, the benefits of investment tax credits are recorded as part of the tax provision. Under Canadian GAAP, such tax credits are classified against the expenditure to which they relate, which is research and development.
 
(g)   We hold certain investments which under Canadian GAAP are recorded at historical costs adjusted for permanent impairment. Under U.S. GAAP they are recorded as available-for-sale securities. Such securities are required to be marked to market, with unrealized holding gains and losses recorded in other comprehensive income.
 
(h)   Under Canadian GAAP, beneficial conversion features attached to certain historical preferred shares were not included in share capital. Under U.S. GAAP, in prior years, a beneficial conversion feature attached to certain preferred shares was accreted as a return to the preferred shareholders. This resulted in an increase in the stated amount of historical share capital.
 
(i)   In 2000 and 2001, we accelerated the vesting of certain employee stock options as part of their severance. Under U.S. GAAP we recorded compensation expense and additional paid in capital in shareholders’ equity equal to the intrinsic value of the options and under Canadian GAAP there was no charge recorded.
 
(j)   Certain adjustments to retained earnings are required to account for the accumulated historical differences between Canadian GAAP and U.S. GAAP as discussed in the other parts of this note.
 
(k)   The cumulative translation adjustment resulting from the translation of our Canadian functional currency financial statements into U.S. dollar for reporting purposes differs between Canadian GAAP and U.S. GAAP due to the difference in the value of our assets and liabilities under the respective GAAP’s.
 
(l)   Recent accounting policy developments include the following:
(i) Comprehensive Income
Commencing with our 2007 fiscal year, the new recommendations of the Canadian Institute of Chartered Accountants (“CICA”) for accounting for comprehensive income (CICA Handbook Section 1530), for the recognition and measurement of financial instruments (CICA Handbook Section 3855) and for hedges (CICA Handbook Section 3865) will apply. The transitional rules for these sections require implementation at the beginning of a fiscal year; and we have not implemented these sections in the nine months ended September 30, 2006. The concept of comprehensive income for purposes of Canadian GAAP will be to include changes in shareholders’ equity arising from unrealized changes in the values of financial instruments.
(ii) Non-Monetary Transactions
The new recommendation of CICA Handbook Section 3831 is applicable commencing in fiscal 2006. The amended recommendations will result in non-monetary transactions normally being measured at fair values, and at carrying values when certain criteria are met. The adoption of CICA Handbook Section 3831 did not have a material impact on our results of operations.
14.   SUBSEQUENT EVENTS
 
    On November 6, 2006, a federal jury hearing claims brought against QLT by Massachusetts Eye and Ear Infirmary (“MEEI”) found QLT liable under Massachusetts state law for unjust enrichment and unfair trade practices and determined that QLT should pay to MEEI a royalty of 3.01% on net sales of Visudyne worldwide. It remains for the court to determine whether this relates to future sales or past and future sales of Visudyne. The jury determined that the unfair trade practices were not committed knowingly or willfully and therefore declined to award enhanced damages. Any award may include interest at court imposed rates and MEEI’s attorneys’ fees. QLT expects to present post-trial motions addressing the effect of the jury’s verdict and to continue to vigorously pursue the defense of this case. It is uncertain when final judgment will be entered. (See Note 12 Contingencies in the consolidated financial statements.)
 
 
    On October 26, 2006, as a result of declining Visudyne sales, we announced plans to restructure our operations in order to reduce our overall cost basis going forward. The cost control efforts include a reduction of our workforce by approximately 80 employees and reduction in R&D and other expenses. We will provide affected employees with severance and human resource support to assist with outplacement. We expect there will be an associated restructuring charge of approximately $5 million in the fourth quarter of 2006.

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ITEM 2. MANAGEMENT’S DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION AND RESULTS OF OPERATIONS
The following information should be read in conjunction with the accompanying unaudited interim consolidated financial statements and notes thereto, which are prepared in accordance with generally accepted accounting principles (“GAAP”) in the United States (“U.S.”) and our audited consolidated financial statements and notes thereto included as part of our 2005 Annual Report on Form 10-K. All of the following amounts are expressed in U.S. dollars unless otherwise indicated.
SPECIAL NOTE REGARDING FORWARD-LOOKING STATEMENTS
This Quarterly Report contains forward-looking statements within the meaning of the United States Private Securities Litigation Reform Act of 1995 and “forward looking information” within the meaning of the Canadian securities legislation which are based on our current expectations and projections. Words such as “anticipate”, “project”, “expect”, “forecast”, “outlook”, “plan”, “intend”, “estimate”, “should”, “may”, “assume”, “continue”, and variations of such words or similar expressions are intended to identify our forward-looking statements. Forward looking statements include, but are not limited to, those in which we state:
    anticipated levels of future sales of our products;
 
    anticipated future operating results;
 
    our expectations as to the outcome of the patent litigation commenced against QLT USA, Inc., a subsidiary of QLT Inc., and Sanofi-Synthelabo, Inc. by TAP Pharmaceuticals, Inc. and its co-plaintiffs;
 
    our expectations as to the outcome of the patent related litigation commenced by Massachusetts Eye and Ear Infirmary against QLT;
 
    our plans to divest our non-core generic dermatology and dental business and related manufacturing facilities;
 
    the anticipated timing and progress of clinical trials;
 
    the anticipated timing of regulatory submissions for our products;
 
    the anticipated timing for, receipt of and our ability to maintain regulatory approvals for our products;
 
    the anticipated timing for, receipt of and our ability to maintain reimbursement approvals for our products in development; and
 
    our expectation as to our eligibility for certain tax benefits resulting from new tax legislation in effect in the Province of British Columbia.
We caution that actual outcomes and results may differ materially from those expressed in our forward-looking statements because such statements are predictions only and they are subject to a number of important risks factors and uncertainties. Risk factors and uncertainties which could cause actual results to differ from what is expressed or implied by our forward-looking statements are described in more detail in our most recent Annual Report on Form 10-K under the headings: “Business — Risk Factors”, “Legal Proceedings”, “Management’s Discussion and Analysis of Financial Condition and Results of Operations” and the “Notes to the Consolidated Financial Statements”. We encourage you to read those descriptions carefully. We caution investors not to place undue reliance on the forward-looking statements contained in this report. These statements, like all statements in this report, speak only as of the date of this report, unless an earlier date is indicated, and, except as required by law and the rules and regulations of the SEC and Canadian regulatory authorities, we undertake no obligation to update or revise the statements.
OVERVIEW
We are a global biopharmaceutical company dedicated to the discovery, development and commercialization of innovative therapies. Our research and development efforts are focused on the discovery and development of pharmaceutical products in the fields of ophthalmology and dermatology. In addition, we utilize two unique technology platforms, photodynamic therapy and atrigel, to create products such as Visudyne® and Eligard®.
Our company was formed in 1981 under the laws of the Province of British Columbia, Canada. In November 2004, we acquired Atrix Laboratories, Inc., a Fort Collins, Colorado based biopharmaceutical company focused on advanced drug delivery. With our acquisition of Atrix (now our wholly owned subsidiary, QLT USA, Inc.) we expanded and diversified our portfolio of approved products, products in development or under regulatory review, and proprietary technologies. (For product revenues, see our Consolidated Financial Statements — Note 8).
Our first commercial product was in the field of photodynamic therapy, or PDT, which uses photosensitizers (light activated drugs) in the treatment of disease. Our lead commercial product, Visudyne, utilizes PDT to treat the eye

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disease known as wet age related macular degeneration, or wet AMD, the leading cause of blindness in people over the age of 55 in North America and Europe.
Visudyne is commercially available in more than 75 countries, including the U.S., Canada, Japan and the European Union countries, for the treatment of a form of wet AMD known as predominantly classic subfoveal choroidal neovascularization, or CNV, and in over 50 countries for the form of wet AMD known as occult subfoveal CNV. Visudyne is reimbursed in the U.S. by the Centers for Medicare & Medicaid Services for certain patients with the occult and minimally classic forms of wet AMD. It is also approved in more than 60 countries, including the U.S., Canada and the European Union countries, for the treatment of subfoveal CNV due to pathologic myopia (severe near-sightedness). In some countries, including the U.S. and Canada, Visudyne is also approved for presumed ocular histoplasmosis or other macular diseases. QLT develops and commercializes Visudyne through a co-development, manufacturing and commercialization agreement with Novartis Ophthalmics of Switzerland (a division of Novartis Pharma AG).
In addition to our lead commercial product Visudyne, we now market (through commercial partners) the Eligard line of products for the treatment of prostate cancer. The Eligard product line includes four different commercial formulations of our Atrigel® technology combined with leuprolide acetate for the treatment of prostate cancer. The U.S. Food and Drug Administration, or FDA, has approved all four products: Eligard 7.5-mg (one-month), Eligard 22.5-mg (three-month), Eligard 30.0-mg (four-month) and Eligard 45.0-mg (six-month). The Eligard 7.5-mg and Eligard 22.5-mg products are also approved in a number of other countries, including some European countries, Canada, Australia, New Zealand and a number of Latin American countries. In addition to the U.S., Eligard 30-mg (four-month) and Eligard 45.0-mg (six-month) are also approved in Canada, Australia and New Zealand (See our Consolidated Financial Statements — Note 12 — Contingencies).
Our most advanced proprietary dermatology product, Aczone™, was approved by the FDA in July 2005 and by Health Canada in June 2006. Although Aczone is approved in the U.S and Canada, it is not yet marketed. A decision with respect to the commercialization of Aczone is pending the outcome of an additional Phase IV clinical study and submission to the FDA to remove a restriction currently on the approved label for the product.
Our efforts to increase our portfolio of products are ongoing. We carry out research and pre-clinical projects in our core therapeutic area of ophthalmology, and other areas such as dermatology. We also conduct contract research and development work on product candidates of third parties using the Atrigel drug delivery system in a number of therapeutic areas from which we can potentially derive royalty and other revenue upon commercialization.
To focus our business on the research and development of proprietary products in our core therapeutic areas, during the first quarter of 2006, we initiated an active plan for the sale of certain non-core assets, including the generic dermatology business, dental business and the manufacturing facility of our subsidiary, QLT USA, Inc. in Fort Collins, Colorado. The generic dermatology business, which is part of a development and commercialization arrangement with Sandoz, Inc., currently comprises eight approved products.
RECENT DEVELOPMENTS
On November 7, 2006, we released positive results of our Phase IV clinical trial of Aczone™ in more than 50 patients with G6PD deficiency that was performed to meet a post-approval commitment requested by the FDA. The purpose of this study was to gather more information about the safety of Aczone, a prescription topical medicine, in treating patients with acne who have certain blood disorders. We intend to submit a label revision supplement to the FDA during the first quarter of 2007. A decision by the FDA on the label review is expected to take approximately 10 months.
On November 6, 2006, a federal jury hearing claims brought against QLT by Massachusetts Eye and Ear Infirmary (“MEEI”) found QLT liable under Massachusetts state law for unjust enrichment and unfair trade practices and determined that QLT should pay to MEEI a royalty of 3.01% on net sales of Visudyne worldwide. It remains for the court to determine whether this relates to future sales or past and future sales of Visudyne. The jury determined that the unfair trade practices were not committed knowingly or willfully and therefore declined to award enhanced damages. Any award may include interest at court imposed rates and MEEI’s attorneys’ fees. QLT expects to present post-trial motions addressing the effect of the jury’s verdict and to continue to vigorously pursue the defense of this case. It is uncertain when final judgment will be entered. (See Note 12 Contingencies in the consolidated financial statements.)
On October 26, 2006, as a result of declining Visudyne sales, we announced plans to restructure our operations in order to reduce our overall cost basis going forward. The cost control efforts include a reduction of our workforce by approximately 80 employees and reduction in R&D and other expenses. We will provide affected employees with severance and human resource support to assist with outplacement.
On September 14, 2006 we announced the final result of our modified “Dutch Auction” tender offer. We accepted for purchase and cancellation 13 million common shares at a price of $8.00 per share, totaling $104 million. These shares represented approximately 14.7% of the shares outstanding as of September 8, 2006. Under this “Dutch Auction” tender offer, shareholders were invited to tender all or a portion of their shares at a price per share that was not less than US$7.00 and not greater than US$8.00. Based on the number of shares tendered and the prices specified by the

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tendering shareholders, we determined the lowest price per share within the range that allowed us to buy 13 million shares properly tendered. The tender offer commenced on August 3, 2006 and expired on September 8, 2006.
CRITICAL ACCOUNTING POLICIES AND ESTIMATES
In preparing our consolidated financial statements, we are required to make certain estimates, judgements and assumptions that we believe are reasonable based upon the information available. These estimates and assumptions affect the reported amounts of assets and liabilities at the date of the financial statements and the reported amounts of revenues and expenses during the periods presented. Significant estimates are used for, but not limited to, stock-based compensation, provisions for non-completion of inventory, assessment of the recoverability of long-lived assets, assessment of impairment of goodwill, accruals for contract manufacturing and research and development agreements, allocation of costs to manufacturing under a standard costing system, allocation of overhead expenses to research and development, determination of fair value of assets and liabilities acquired in the purchase business combinations, determination of fair value of assets held for sale, and provisions for taxes and contingencies. The significant accounting policies which we believe are the most critical to aid in fully understanding and evaluating our reported financial results include those which follow:
Reporting Currency and Foreign Currency Translation
We use the U.S. dollar as our reporting currency, while the Canadian dollar is the functional currency for QLT Inc., and the U.S. dollar is the functional currency for our U.S. subsidiaries. Our consolidated financial statements are translated into U.S. dollars using the current rate method. Assets and liabilities are translated at the rate of exchange prevailing at the balance sheet date. Shareholders’ equity is translated at the applicable historical rates. Revenues and expenses are translated at a weighted average rate of exchange for the respective years. Translation gains and losses from the application of the U.S. dollar as the reporting currency are included as part of the cumulative foreign currency translation adjustment, which is reported as a component of shareholders’ equity under accumulated other comprehensive income (loss). As of September 30, 2006, our accumulated other comprehensive income totalled $91.8 million.
Revenue Recognition
Net Product Revenue
Our net product revenues are derived from sales of Visudyne® and Eligard®.
With respect to Visudyne, under the terms of our collaborative agreement with Novartis Ophthalmics we are responsible for Visudyne manufacturing and product supply, and Novartis Ophthalmics is responsible for marketing and distribution of Visudyne. Our agreement with Novartis Ophthalmics provides that the calculation of total revenue for the sale of Visudyne be composed of three components: (1) an advance on the cost of inventory sold to Novartis Ophthalmics, (2) an amount equal to 50% of Novartis Ophthalmics’ net proceeds from Visudyne sales (determined according to a contractual agreed definition) derived from the sale of Visudyne to end-users, and (3) the reimbursement of other specified costs incurred and paid for by us. We recognize revenue from the sale of Visudyne when persuasive evidence of an arrangement exists, delivery to Novartis Ophthalmics has occurred, the end selling price of Visudyne is fixed or determinable, and collectibility is reasonably assured. Under the calculation of revenue noted above, this occurs when Novartis Opthalmics has sold Visudyne to its end customers. Our revenue from Visudyne will fluctuate dependent upon Novartis Ophthalmics’ ability to market and distribute Visudyne to end customers.
With respect to Eligard, under the terms of the license agreements with our commercial licensees, we are responsible for the manufacture of Eligard and receive from our commercial licensees an agreed upon sales price upon shipment to them. We also earn royalties from certain commercial licensees based upon their sales of Eligard products to end customers, which royalties are included in net royalty revenue. We recognize net revenue from product sales when persuasive evidence of an arrangement exists, product is shipped and title is transferred to our commercial licensees, collectibility is reasonably assured and the price is fixed or determinable. Our net product revenue from Eligard will fluctuate dependent upon our ability to deliver Eligard products to our commercial licensees. Our Eligard commercial licensees are responsible for all products after shipment from our facility. Under this calculation of revenue, we recognize net product revenue from Eligard at the time of shipment to our commercial licensees.
We do not offer rebates or discounts in the normal course of business and have not experienced any material product returns; accordingly, we do not provide an allowance for rebates, discounts, and returns.

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Net Royalties
We recognize net royalties when product is shipped by certain of our commercial licensees to end customers based on royalty rates specified in our agreements with them. Generally, royalties are based on estimated net product sales (gross sales less discounts, allowances and other items) and calculated based on information supplied to us by our commercial licensees.
Contract Research and Development
Contract research and development revenues consist of non-refundable research and development funding under agreements with third parties with whom we have research or development relationships or licenses. Contract research and development funding generally compensates us for discovery, preclinical and clinical expenses related to the collaborative development programs for certain products and product candidates, and is recognized as revenue at the time research and development activities are performed under the terms of those agreements. For fixed price contracts, we recognize contract research and development revenue over the term of the agreement consistent with the pattern of work performed. Amounts received under those agreements for work actually performed are non-refundable even if the research and development efforts performed by us do not eventually result in a commercial product. Contract research and development revenues earned in excess of payments received are classified as contract research and development receivables and payments received in advance of revenue recognition are recorded as deferred revenue.
Licensing and milestones
We have licensing agreements that generally provide for non-refundable license fees and/or milestone payments. The licensing agreements typically require a non-refundable license fee and allow licensees to sell our proprietary products in a defined territory for a defined period. A milestone payment is a payment made by a licensee to us upon achievement of a pre-determined event, as defined in the applicable agreement. Non-refundable license fees and milestone payments are initially reported as deferred revenue. They are recognized as revenue over the remaining contractual term or as covered by patent protection, whichever is earlier, using the straight-line method or until the agreement is terminated. No milestone revenue is recognized until we have completed the required milestone-related services as set forth in licensing agreements.
Cost of Sales
Visudyne cost of sales, consisting of expenses related to the production of bulk Visudyne and royalty expense on Visudyne sales, are charged against earnings in the period that Novartis Ophthalmics sells to end customers. Cost of sales related to the production of various Eligard, generic dermatology, and dental products are charged against earnings in the period of the related product sale to our commercial licensees. We utilize a standard costing system, which includes a reasonable allocation of overhead expenses, to account for inventory and cost of sales, with adjustments being made periodically to reflect current conditions. Our standard costs are estimated based on management’s best estimate of annual production volumes and material costs. Overhead expenses comprise direct and indirect support activities related to the manufacture of bulk Visudyne, various Eligard, generic dermatology, and dental products and involve costs associated with activities such as quality inspection, quality assurance, supply chain management, safety and regulatory. Overhead expenses are allocated to inventory at various stages of the manufacturing process under a standard costing system, and eventually to cost of sales as the related products are sold to our commercial licensees or in the case of Visudyne, by Novartis Ophthalmics to third parties. While we believe our standard costs are reliable, actual production costs and volume changes may impact inventory, cost of sales, and the absorption of production overheads. We record a provision for the non-completion of product inventory based on our history of batch completion to provide for the potential failure of inventory batches to pass quality inspection. The provision is calculated at each stage of the manufacturing process. We estimate our non-completion rate based on past production and adjust our provision based on actual production volume. A batch failure may utilize a significant portion of the provision as a single completed batch currently costs up to $1.2 million, depending on the product and the stage of production. We provide a reserve for obsolescence of Eligard inventory and component materials based on our periodic evaluation of potential obsolete inventory and our history of inventory obsolescence.
Stock-Based Compensation
In the past, we accounted for our stock-based compensation under the intrinsic value method in accordance with the provisions of Accounting Principles Board (APB) Opinion No. 25, Accounting for Stock Issued to Employees, and provided the pro forma disclosures of net income and net income per share.

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In December 2004, the Financial Accounting Standards Board, or FASB, issued SFAS 123 Revised, Share-Based Payment, or SFAS 123R. The statement eliminates the alternative to account for stock-based compensation using APB 25 and requires such transactions be recognized as compensation expense in the statement of earnings based on their fair values on the date of the grant, with the compensation expense recognized over the period in which a grantee is required to provide service in exchange for the stock award. We have adopted this statement effective January 1, 2006 using a modified prospective application as defined in SFAS 123R. As such, the compensation expense recognition provisions are applicable to new awards and to any awards modified, repurchased or cancelled after the adoption date. Additionally, for any unvested awards outstanding at the adoption date, we recognize compensation expense over the remaining vesting period. Estimates of fair value are determined using the Black-Scholes option pricing model. The use of this model requires certain assumptions regarding the volatility, term, risk free interest rate and forfeiture experienced by the holder. SFAS 123R also requires the benefits of tax deductions in excess of recognized compensation cost to be reported as a financing cash flow, rather than as an operating cash flow as previously required. We are unable to utilize the tax benefits until we establish a history of profitability at QLT USA.
In the third quarter of 2006, stock based compensation of $1.0 million was expensed as follows: $0.6 million to research and development costs, $0.3 million to selling, general and administrative costs, $0.1 million to discontinued operations and a negligible amount to cost of sales. The assumptions used for options granted during the third quarter of 2006 included a volatility factor of 44.1%, a 3.3 year term until exercise, and a 3.8% risk free interest rate expected to be experienced by the holder.
Research and Development
Research and development costs are expensed as incurred and consist of direct and indirect expenditures, including a reasonable allocation of overhead expenses, associated with our various research and development programs. Overhead expenses comprise general and administrative support provided to the research and development programs and involve costs associated with support activities such as facility maintenance, utilities, office services, information technology, legal, accounting and human resources. The allocation of overhead expenses requires us to make estimates as to the type and level of support required by our research and development programs. Changes in the composition of our workforce and the types of support activities are factors that can influence our allocation of overhead expenses. Costs related to the acquisition of development rights for which no alternative use exists are classified as research and development and expensed as incurred. Patent application, filing and defense costs are also expensed as incurred. Research and development costs also include funding provided to collaborative partners for joint research and development programs.
Income Taxes
Income taxes are reported using the asset and liability method, whereby deferred tax assets and liabilities are recognized for the future tax consequences attributable to: (i) differences between the financial statement carrying amounts of existing assets and liabilities and their respective tax bases, and (ii) operating loss and tax credit carry forwards using applicable enacted tax rates. An increase or decrease in these tax rates will increase or decrease the carrying value of future net tax assets resulting in an increase or decrease to net income. Income tax credits are included as part of the provision for income taxes. Significant estimates are required in determining our provision for income taxes. Some of these estimates are based on interpretations of existing tax laws or regulations. Various internal and external factors may have favorable or unfavorable effects on our future effective tax rate. These factors include, but are not limited to, changes in tax laws, regulations and/or rates, changing interpretations of existing tax laws or regulations, changes in estimates of prior years’ items, results of tax audits by tax authorities, future levels of research and development spending, and changes in overall levels of pre-tax earnings. The realization of our deferred tax assets is primarily dependent on generating sufficient taxable income prior to expiration of any loss carry forward balance. A valuation allowance is provided when it is more likely than not that a deferred tax asset may not be realized.
Legal Proceedings
We are involved in a number of legal actions, the outcomes of which are not within our complete control and may not be known for prolonged periods of time. In these legal actions, the claimants seek damages, as well as other relief, which, if granted, could require significant expenditures. We record a liability in the consolidated financial statements for these actions when a loss is known or considered probable and the amount can be reasonably estimated. If the loss is not probable or cannot reasonably be estimated, a liability is not recorded in the consolidated financial statements. Our potentially material legal proceedings are discussed in Note 12 to the consolidated financial statements. As of September 30, 2006, no reserve has been established related to these proceedings.

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Long-Lived and Intangible assets
We incur costs to purchase and occasionally construct property, plant and equipment. The treatment of costs to purchase or construct these assets depends on the nature of the costs and the stage of construction. Costs incurred in the initial design and evaluation phase, such as the cost of performing feasibility studies and evaluating alternatives are charged to expense. Costs incurred in the committed project planning and design phase, and in the construction and installation phase, are capitalized as part of the cost of the asset. We stop capitalizing costs when an asset is substantially complete and ready for its intended use. Since 2003, we have been depreciating plant and equipment using the straight-line method over their estimated economic lives, which range from 3-40 years. Determining the economic lives of plant and equipment requires us to make significant judgements that can materially impact our operating results.
We periodically evaluate our long-lived assets for potential impairment under SFAS 144, Accounting for the Impairment or Disposal of Long-lived Assets. We perform these evaluations whenever events or changes in circumstances suggest that the carrying amount of an asset or group of assets is not recoverable. If impairment recognition criteria in SFAS 144 have been met, we charge impairments of the long-lived assets to operations.
In accounting for acquisitions, we allocate the purchase price to the fair value of the acquired tangible and intangible assets, including in-process research and development, or IPR&D. We generally determine the value of acquired intangible assets and IPR&D using a discounted cash flow model, which requires us to make assumptions and estimates about, among other things: the time and investment that is required to develop products and technologies; our ability to develop and commercialize products before our competitors develop and commercialize products for the same indications; the amount of revenue to be derived from the products; and appropriate discount rates to use in the analysis. Use of different estimates and judgements could yield materially different results in our analysis, and could result in materially different asset values and IPR&D charges.
As of September 30, 2006, we have $4.9 million of net acquired intangibles, all of which relates to the generic dermatology products of QLT USA, acquired as part of the acquisition of Atrix. We previously amortized acquired intangible assets using the straight-line method over their estimated economic lives, which range from 16 to 17 years. During the first quarter of 2006, we initiated an active plan to divest our non-core assets, including the generic dermatology and dental business of QLT USA, and reclassified our acquired intangible assets for current and prior periods as assets held for sale and ceased recording amortization expense. Assets held for sale are recorded at the lower of their carrying value or their estimated fair value less costs to sell. During the third quarter of 2006, we recorded an impairment charge of $8.6 million as events and circumstances indicated an impairment to our assets held for sale. The determination of the fair value of assets held for sale was based on future discounted cash flows and requires significant judgements and estimates.
Impairment of Goodwill
In accordance with Statement of Financial Accounting Standard, or SFAS 142, Goodwill and Other Intangibles, we are required to perform impairment tests annually or whenever events or changes in circumstances suggest that the carrying value of an asset may not be recoverable. We made assumptions and estimates regarding product development, market conditions and cash flows in determining the valuation of goodwill and intangibles, all of which related to our acquisition of Atrix (now QLT USA). During the quarter ended September 30, 2006, we performed our annual impairment test, and we did not identify any potential impairment as the fair value of our reporting unit exceeded its carrying amount. Our estimates of fair value are based upon factors such as projected future revenue, probability of success of our products in development, and other uncertain elements requiring significant judgements. While we use available information to prepare our estimates and to perform impairment evaluations, actual results in the future could differ significantly. Impairment tests in future periods may result in impairment charges which could materially impact our future reported results.
Recently Issued and Recently Adopted Accounting Standards
In March 2005, the FASB issued FIN 47, “Accounting for Conditional Asset Retirement Obligations—an interpretation of FASB Statement No. 143” (“FIN 47”). This Interpretation clarifies that the term conditional asset retirement obligation as used in FASB Statement No. 143, Accounting for Asset Retirement Obligations, refers to a legal obligation to perform an asset retirement activity in which the timing and (or) method of settlement are conditional on a future event that may or may not be within the control of the entity. An entity is required to recognize a liability for the fair value of a conditional asset retirement obligation if the fair value of the liability can be reasonably estimated. The fair value of a liability for the conditional asset retirement obligation should be recognized when incurred—generally upon acquisition, construction, or development and (or) through the normal operation of the

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asset. FIN 47 is effective for fiscal years ending after December 15, 2005. The adoption of FIN 47 did not have a material impact on our financial position or results of operations.
In May 2005, the FASB issued SFAS 154, “Accounting Changes and Error Corrections—a replacement of APB Opinion 20 and FASB Statement 3” (“SFAS 154”). This Statement replaces APB Opinion 20, “Accounting Changes” and FASB Statement 3, “Reporting Accounting Changes in Interim Financial Statements,” and changes the requirements for the accounting for and reporting of a change in accounting principle. SFAS 154 applies to all voluntary changes in an accounting principle. It also applies to changes required by an accounting pronouncement in the unusual instance that the pronouncement does not include specific transition provisions. When a pronouncement includes specific transition provisions, those provisions should be followed. SFAS 154 is effective for accounting changes and error corrections occurring in fiscal years beginning after December 15, 2005. The adoption of SFAS 154 did not have a material impact on our results of operations.
In February 2006, the FASB issued SFAS 155, “Accounting for Certain Hybrid Financial Instruments - an amendment of FASB statement 133 and 140 (“SFAS 155”). This Statement simplifies accounting for certain hybrid financial statements by permitting fair value remeasurements for any hybrid financial instrument that contains an embedded derivative that would otherwise require bifurcation, and eliminates the restriction on the passive derivative instruments that a qualifying special - purpose entity may hold. This Statement is effective for all financial instruments acquired or issued after the beginning of an entity’s first fiscal year that begins after September 15, 2006. We believe the adoption of SFAS 155 will not have a material impact on our results of operations.
In July 2006, the FASB issued FIN 48 “Accounting for Uncertainty in Income Taxes — an interpretation of FASB Statement No. 109”. This interpretation provides guidance on the financial statement recognition and measurement of a tax position taken or expected to be taken in a tax return. FIN 48 also provides guidance on derecognition, classification, interest and penalties, accounting in interim periods, disclosures, and transition. FIN 48 is effective for fiscal years beginning after December 15, 2006. We are currently evaluating the impact of this standard on our Consolidated Financial Statements.
In September 2006, the FASB issued SFAS No. 157 “Fair Value Measurements” (“SFAS No. 157”) which defines fair value, establishes a framework for measuring fair value in generally accepted accounting principles, and expands disclosures about fair value measurements. This statement does not require any new fair value measurements and is effective for fiscal periods beginning after November 15, 2007. We are currently evaluating the impact of this standard on our Consolidated Financial Statements.

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RESULTS OF OPERATIONS
For the three months ended September 30, 2006, we recorded a net loss of $3.7 million, or $0.04 diluted net loss per common share. For the nine months ended September 30, 2006, we recorded a net profit of $15.9 million, or $0.18 diluted net income per common share. These results compare with net income of $12.9 million and $45.0 million, or $0.14 and $0.47 diluted net income per common share, for the three and nine months ended September 30, 2005. Detail discussion and analysis of our results of operations are as follows:
Revenues
Net Product Revenue
     Net product revenue was determined as follows:
                                 
    For the three months ended   For the nine months ended
    September 30,   September 30,
(In thousands of U.S. dollars)   2006   2005   2006   2005
(Unaudited)                                
Visudyne® sales by Novartis Ophthalmics
  $ 75,137     $ 123,733     $ 277,259     $ 376,521  
Less: Marketing and distribution costs
    (32,289 )     (32,497 )     (96,796 )     (104,653 )
Less: Inventory costs
    (3,963 )     (5,104 )     (14,669 )     (18,601 )
Less: Royalties to third parties
    (1,581 )     (2,757 )     (5,942 )     (8,371 )
     
 
  $ 37,304     $ 83,375     $ 159,852     $ 244,896  
     
 
                               
QLT’s (50%) share of Novartis Ophthalmics’ net proceeds from Visudyne sales
  $ 18,652     $ 41,688     $ 79,926     $ 122,448  
Add: Advance on inventory costs from Novartis Opthalmics
    3,153       4,353       11,922       14,495  
Add: Royalties reimbursed to QLT
    1,552       2,656       5,944       8,103  
Add: Other costs reimbursed to QLT
    2,406       1,242       4,393       3,597  
     
Revenue from Visudyne® sales
  $ 25,763     $ 49,939     $ 102,185     $ 148,643  
 
                               
Net product revenue from Eligard® and other products
    5,846       5,953       17,643       13,231  
     
 
  $ 31,609     $ 55,892     $ 119,828     $ 161,874  
     
For the three months ended September 30, 2006, revenue from Visudyne sales of $25.8 million decreased by $24.1 million (or 48%) over the three months ended September 30, 2005. The decrease was primarily due to a 39% decline in Visudyne sales over the same quarter in the prior year as a result of decreased end user demand, particularly in the United States due to competing therapies. In the third quarter of 2006, approximately 15% of the total Visudyne sales by Novartis Ophthalmics were in the U.S., compared to approximately 41% in third quarter of 2005. Overall the ratio of our share of revenue on final sales compared to Visudyne sales was 25% in the third quarter of 2006, down from 34% in the third quarter of 2005 primarily due to marketing and distribution costs remaining fairly consistent in comparison to the same period in the prior year.
For the nine months ended September 30, 2006, revenue from Visudyne of $102.2 million decreased by $46.5 million (or 31%) over the prior year period. The decrease was primarily due to a 26% decline in Visudyne sales year over year as a result of decreased end user demand, particularly in the United States due to competing therapies. In the nine months ended September 30, 2006, approximately 22% of total Visudyne sales by Novartis Ophthalmics were in the U.S., compared to approximately 40% in the nine months ended September 30, 2005. Overall, the ratio of our share of revenue on final sales compared to Visudyne sales was 29% in the nine months ended September 30, 2006, down from 33% in the prior year period. Marketing and distribution costs decreased to $96.8 million for the nine months ended September 30, 2006, compared to $104.7 million in the prior year.
For the three months ended September 30, 2006, net product revenue from Eligard of $5.8 million decreased by $0.1 million (or 2%) over the same period in the prior year due to the timing of inventory shipments to licensees. For the nine months ended September 30, 2006, net product revenue from Eligard of $17.6 million increased by $4.4 million (or 33%) over the same period in the prior year primarily due to launches of Eligard in additional countries in Europe.

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Net Royalties
For the three months ended September 30, 2006, royalty revenue of $6.1 million was $2.2 million (or 58%) higher compared to the same period in 2005. For the nine months ended September 30, 2006, royalty revenue of $14.9 million was $3.5 million (or 30%) higher compared to the same period in 2005. The increase was due to higher Eligard sales in the U.S., additional Eligard launches in Europe, and growth in Canada.
Contract Research and Development Revenue
We received non-refundable research and development funding from our strategic partners, which was recorded as contract research and development revenue. For the three months ended September 30, 2006, contract research and development revenue totalled $0.3 million, down 76% compared to the same period in 2005. For the nine months ended September 30, 2006, contract revenue totalled $0.9 million, down 89% compared to the same period in 2005. The decrease was primarily due to (i) the decline in research and development funding from Novartis as our level of research and development activities for Visudyne programs fell below that of Novartis, and (ii) the termination in mid-2005 of the Collaboration, Licensing and Supply agreement previously entered into with Astellas US LLC to develop Aczone.
Costs and Expenses
Cost of Sales
For the three months ended September 30, 2006, cost of sales decreased 19% to $10.5 million compared to $12.9 million for the same period in 2005. The decrease was primarily due to the lower sales volume of Visudyne in comparison to the same period last year. For the nine months ended September 30, 2006, cost of sales decreased by 11% to $32.2 million compared to $36.2 million for the same period in 2005. The decrease was due to lower sales of Visudyne, partially offset by higher shipments of Eligard to our commercial licensees. Cost of sales related to revenue from Visudyne decreased from $7.4 million to $5.1 million in the three months ended September 30, 2006 compared to the same period in 2005, and decreased from $24.5 million to $17.3 million in the nine months ended September 30, 2006. Compared to the same periods in 2005, cost of sales related to revenue from Eligard decreased to $5.3 million from $5.5 million in the three months ended September 30, 2006, and increased from $11.7 million to $14.9 million in the nine months ended September 30, 2006.
Research and Development
Research and development, or R&D, expenditures decreased 14% to $13.6 million for the three months ended September 30, 2006 compared to $15.7 million in the same period in 2005. For the nine months ended September 30, 2006, expenditures decreased by 7% to $43.7 million compared to $47.0 million in the same period in 2005. The decrease was due to reduced spending on Visudyne, Lemuteporfin and Eligard projects, partly offset by in-licensing fees of $1.9 million in the second quarter of 2006 and stock compensation expense of $0.6 million and $1.9 million for the three and nine months ended September 30, 2006.
Selling, General and Administrative Expenses
For the three months ended September 30, 2006, selling, general and administrative, or SG&A, expenses increased 25% to $10.0 million compared to $8.0 million for the three months ended September 30, 2005. For the nine months ended September 30, 2006, SG&A expenses increased 58% to $27.6 million compared to $17.5 million for the same period in 2005. The increases were primarily due to higher legal fees related to ongoing litigation of QLT USA of $4.6 million and $12.7 million for the three and nine months ended September 30, 2006. Excluding legal fees, our SG&A expenses would have declined by $2.6 million and $2.6 million respectively, for the three and nine months ended September 30, 2006 primarily due to our 2005 third quarter SG&A expenses having included the separation costs associated with our former CEO.
Restructuring (Recovery) Charge
We adjusted our restructuring accrual in the second quarter of 2006 to reflect more current estimates in the restructuring plan and recorded a credit of $0.2 million. In 2005, we recorded a $3.4 million restructuring charge as a result of integration activities related to our acquisition of Atrix (now QLT USA).

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Investment and Other Income
Net Foreign Exchange (Losses) Gains
Net foreign exchange gains (losses) comprise gains (losses) from the impact of foreign exchange fluctuation on our cash and cash equivalents, short-term investments, derivative financial instruments, foreign currency receivables, foreign currency payables and U.S. dollar denominated long-term debt. For the three months ended September 30, 2006, we recorded net foreign exchange gains of $0.6 million versus net foreign exchange gains of $0.5 million in the same period in 2005. For the nine months ended September 30, 2006, we recorded net foreign exchange losses of $2.9 million versus net foreign exchange gains of $3.7 million in the same period in 2005. (See “Liquidity and Capital Resources – Interest and Foreign Exchange Rates”.)
Details of our net foreign exchange gains (losses) were as follows:
                                 
    For the three months ended   For the nine months ended
    September 30,   September 30,
    2006   2005   2006   2005
(In thousands of U.S. dollars)                                
Cash and cash equivalents and short-term investments
  $ 328     $ (8,892 )   $ (6,711 )   $ (5,242 )
U.S. dollar long-term debt
    (246 )     8,913       6,723       5,622  
Foreign exchange contracts
    702       2,729       (2,738 )     6,997  
Foreign currency receivables and payables
    (203 )     (2,244 )     (160 )     (3,681 )
     
Net foreign exchange (losses) gains
  $ 581     $ 506     $ (2,886 )   $ 3,696  
     
Interest Income
For the three months ended September 30, 2006, interest income increased by $2.0 million to $5.5 million from $3.5 million for the same period in 2005, and for the nine months ended September 30, 2006, interest income increased by $6.3 million to $15.3 million from $9.1 million for the same period in 2005. The increase was due to higher interest rates compared to the same periods in the prior year.
Interest Expense
Interest expense comprised interest accrued on the 3% convertible senior notes issued on August 15, 2003 and amortization of deferred financing expenses related to the placement of these notes. For the three and nine months ended September 30, 2006, interest expense of $1.6 million and $4.9 million, respectively, was essentially equal to the same periods in 2005.
Other Gains
In August 2006, we sold the non-U.S. rights of our BEMA technology for an upfront payment of $1.0 million and future considerations. In June 2006, we received payment from Axcan Pharma, Inc., or Axcan, of CAD $2.5 million (USD $2.2 million) representing the last milestone payment owed to us from Axcan related to the sale of our Photofrin business to them in 2000.
Discontinued Operations
In February 2006, we initiated an active plan to divest of certain non-core assets, particularly the generic dermatology business, dental business and related manufacturing facility of our subsidiary, QLT USA, Inc in Fort Collins, Colorado. The divestiture of these assets is consistent with our strategy of concentrating our resources on the research and development of proprietary products in our core therapeutic areas. In accordance with SFAS No. 144, “Accounting for the Impairment or Disposal of Long-lived Assets”, the results of operations of the generic dermatology and dental businesses have been excluded from continuing operations and reported as discontinued operations for the current and prior periods. In addition, the assets included as part of this divestiture have been reclassified as held for sale in the Consolidated Balance Sheet. During the third quarter of 2006, we recorded an impairment charge of $8.6 million as events and circumstances indicated an impairment to our assets held for sale. The indicators of impairment were the failure to receive regulatory approval for a late stage generic dermatology product and a launch delay for another product. During the three months ended September 30, 2006, we recorded a loss from discontinued operations, net of income taxes, of $9.9 million compared to a loss of $1.4 million for the same period in 2005, due to impairment and other charges related to the failure to receive approval for a late stage product. For the nine months ended September 30, 2006, we recorded a loss from discontinued operations, net of income taxes, of $11.2 million compared to a loss of $4.4 million for the same period in 2005, due to impairment and other charges

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related to the failure to receive approval for a late stage product offset by increased sales of generic dermatology products and the cessation of depreciation and amortization on assets held for sale. We do not expect any continuing involvement with these businesses following disposition and we expect to sell these assets prior to March 2007.
LIQUIDITY AND CAPITAL RESOURCES
We have financed operations, product development and capital expenditures primarily through proceeds from our commercial operations, public and private sales of equity securities, private placement of convertible senior notes, licensing and collaborative funding arrangements with strategic partners, and interest income.
The primary drivers of our operating cash flows during the three and nine months ended September 30, 2006 were cash payments related to the following: income tax payment, R&D activities, SG&A expenses, severances and related expenses associated with restructuring activities, legal expenses related to various legal proceedings, raw materials purchases, contract manufacturing fees for the manufacture of Visudyne, manufacturing costs related to the production of Eligard, and interest expense related to our convertible notes offset by cash receipts from product revenues, and royalties.
For the three months ended September 30, 2006, we generated $11.7 million of cash from operations as opposed to $22.9 million for the same period in 2005. Lower cash receipts from Visudyne sales and contract research and development of $20.7 million, higher income tax instalments of $6.6 million, higher foreign exchange contract losses of $3.4 million, were offset by higher cash receipts from Eligard and generic dermatology product sales, royalties, and licensing and milestone payments of $1.6 million, lower operating and inventory related expenditures of $15.0 million, other gains of $1.0 million representing the upfront payment from the sale of the non-U.S. rights of our BEMA technology, and higher interest income of $1.8 million.
During the three months ended September 30, 2006, capital expenditures and a decrease in short-term investments accounted for the most significant cash flows provided by investing activities. We used $1.3 million for the purchase of property, plant and equipment.
For the three months ended September 30, 2006 our cash flows used in financing activities consisted primarily of common shares repurchased, net of share repurchase costs, for $104.3 million offset by cash receipts of $0.1 million from stock option exercises.
For the nine months ended September 30, 2006, we generated $7.6 million of cash from operations as opposed to $70.3 million for the same period in 2005. Lower cash receipts from Visudyne sales and contract research and development of $41.1 million, higher income tax instalments of $34.7 million, higher foreign exchange contract losses of $0.2 million, were offset by higher cash receipts from Eligard and generic dermatology product sales, royalties, and licensing and milestone payments of $2.3 million, lower operating and inventory related expenditures of $1.1 million, other gains of $3.2 million representing the last milestone payment owed to us from Axcan Pharma Inc. related to the sale of our Photofrin business and the upfront payment from the sale of the non-U.S. rights of our BEMA technology, and higher interest income of $5.9 million.
During the nine months ended September 30, 2006, capital expenditures and an increase in short-term investments and restricted cash accounted for the most significant cash flows used in investing activities. We used $4.8 million for the purchase of property, plant and equipment.
For the nine months ended September 30, 2006, our cash flows used in financing activities consisted primarily of common shares repurchased, net of share repurchase costs, for $127.8 million offset by cash receipts of $0.7 million from stock option exercises.
Interest and Foreign Exchange Rates
We are exposed to market risk related to changes in interest and foreign currency exchange rates, each of which could adversely affect the value of our current assets and liabilities. At September 30, 2006, we had an investment portfolio consisting of fixed interest rate securities with an average remaining maturity of approximately 29 days. If market interest rates were to increase immediately and uniformly by 10% of levels at September 30, 2006, the fair value of the portfolio would decline by an immaterial amount.
At September 30, 2006, we had $356.7 million in cash, cash equivalents short-term investments and restricted cash, and $172.5 million of debt. To offset the foreign exchange impact of our $172.5 million U.S. dollar-denominated

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debt, we held at least the equivalent amount in U.S. dollar denominated cash, cash equivalents and short-term investments such that if the U.S. dollar were to decrease in value by 10% against the Canadian dollar, the decline in fair value of our U.S. dollar-denominated cash, cash equivalents and short-term investments would be mostly offset by the decline in the fair value of our $ 172.5 million U.S. dollar denominated long-term debt, resulting in an immaterial amount of unrealized foreign currency translation loss. As the functional currency of our U.S. subsidiaries is the U.S. dollar, the U.S. dollar-denominated cash, cash equivalents and short-term investments holdings of our U.S. subsidiaries do not result in foreign currency gains and losses in operations.
We enter into foreign exchange contracts to manage exposures to currency rate fluctuations related to our expected future net income and cash flows. The net unrealized gains (losses) in respect of such foreign currency contracts for the three and nine months ended September 30, 2006, were approximately $1.9 million and $(0.5) million respectively, and were included as part of the net foreign exchange losses in our results of operations.
We purchase goods and services primarily in Canadian and U.S. dollars and earn a significant portion of our revenues in U.S. dollars. Foreign exchange risk is also managed by satisfying U.S. dollar denominated expenditures with U.S. dollar cash flows or assets.
Contractual Obligations
Our material contractual obligations as of September 30, 2006 comprised our long-term debt, supply agreements with contract manufacturers, and clinical and development agreements. We also had operating lease commitments for office space and office equipment. Details of these contractual obligations are described in our Annual Report on Form 10-K for the year ending December 31, 2005.
Off-Balance Sheet Arrangements
In the course of our business, we regularly provide indemnities with respect to certain matters, including product liability, patent infringement, contractual breaches and misrepresentations, and other indemnities to third parties under the clinical trial, license, service, manufacturing, supply, distribution and other agreements that we enter into in the normal course of our business. In addition, under the agreement entered into between QLT USA, Inc. and Sanofi-Synthelabo, Inc. with respect to the marketing and sale of Eligard in the U.S. and Canada, QLT USA, Inc. has provided to Sanofi-Synthelabo and its affiliates certain indemnities with respect to certain defined matters including certain intellectual property infringement claims that may arise in connection with the litigation commenced by TAP Pharmaceuticals, Inc. and its co-plaintiffs against QLT USA, Inc. and Sanofi-Synthelabo, Inc. (see our Consolidated Financial Statements — Note 12 - Contingencies).
Except as described above and the contractual arrangements described in the Contractual Obligations section, we do not have any other off-balance sheet arrangements that are currently material or reasonably likely to be material to our financial position or results of operations.
General
We believe that our available cash resources and working capital, and our cash generating capabilities, should be sufficient to satisfy the funding of ongoing product development programs and other operating and capital requirements, including our recently completed tender offer to purchase up to 13 million of our common shares, and the in-licensing or acquisition of products and technologies for the reasonably foreseeable future. The nature and form of any future in-licensing or acquisition may have a material impact on our financial position and results of operations. Depending on the overall structure of current and future strategic alliances, we may have additional capital requirements related to the further development, marketing and distribution of existing or future products.
Our working capital and capital requirements will depend upon numerous factors, including: the status of competitors; the outcome of legal proceedings (see our Consolidated Financial Statements - Note 12 — Contingencies); the progress of our preclinical and clinical testing; fluctuating or increasing manufacturing requirements and R&D programs; the timing and cost of obtaining regulatory approvals; the levels of resources that we devote to the development of manufacturing, marketing and support capabilities; technological advances; the cost of filing, prosecuting and enforcing our patent claims and other intellectual property rights; and our ability to establish collaborative arrangements with other organizations.
We may require additional capital in the future to fund any damage awards resulting from legal proceedings, clinical and product development costs for certain product applications or other technology opportunities, and strategic acquisitions of products, product candidates, technologies or other businesses. Accordingly, we may seek funding from a combination of sources, including product licensing, joint development and new collaborative arrangements,

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additional equity or debt financing or from other sources. No assurance can be given that additional funding will be available or, if available, on terms acceptable to us. If adequate capital is not available, our business could be materially and adversely affected.
ITEM 3. QUANTITATIVE AND QUALITATIVE DISCLOSURES ABOUT MARKET RISK
See “Management’s Discussion and Analysis of Financial Condition and Results of Operations – Liquidity and Capital Resources” and Note 10 to the unaudited consolidated financial statements as well as our Annual Report on Form 10-K for the year ended December 31, 2005.
ITEM 4. CONTROLS AND PROCEDURES
(a) Evaluation of Disclosure Controls and Procedures
We maintain a set of disclosure controls and procedures designed to ensure that information required to be disclosed in filings made pursuant to the Securities Exchange Act of 1934 is recorded, processed, summarized and reported within the time periods specified and in accordance with the Securities and Exchange Commission’s rules and forms. Our principal executive and financial officers have evaluated the Company’s disclosure controls and procedures as of the end of the period covered by this report and concluded that the Company’s disclosure controls and procedures were effective in ensuring that material information relating to the Company was made known to management, including the Chief Executive Officer and Chief Financial Officer, by others within the Company during the period in which this report was being prepared.
(b) Changes in Internal Controls
In July 2006, our subsidiary, QLT USA, upgraded its enterprise resource planning (or ERP) system. We believe the upgrade of this system, a system designed for mid-size manufacturers, will enhance our operational efficiency and effectiveness and further improve our internal controls that were previously considered effective.
Except for the preceding change, there was no change to our internal controls over financial reporting in connection with this evaluation that has materially affected, or is reasonably likely to materially affect, our internal controls over financial reporting.

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PART II — OTHER INFORMATION
ITEM 1. LEGAL PROCEEDINGS
Information pertaining to legal proceedings can be found in “Part I, Item 1 Financial Statements — Notes to the Consolidated Financial Statements — Note 12 Contingencies”, and is incorporated by reference herein.
ITEM 1A. RISK FACTORS
In addition to the other information set forth in this report, you should carefully consider the factors discussed in “Part I, Item 1A Risk Factors” in our Annual Report on Form 10-K for the year ended December 31, 2005, which could materially affect our business, financial condition or future results. The risks described in our Annual Report on Form 10-K are not the only risks facing our Company. Additional risks and uncertainties not currently known to us or that we currently deem not to be material also may materially adversely affect our business, financial condition and/or operating results.
ITEM 2. UNREGISTERED SALES OF EQUITY SECURITIES, USE OF PROCEEDS AND ISSUER PURCHASES OF EQUITY SECURITIES
The following table sets forth information regarding our purchases of common shares on a monthly basis during the three months ended September 30, 2006:
                                 
Issuer Purchases of Equity Securities
                    Total Number of   Maximum Number
    Total           Shares Purchased as   of Shares that May
    Number of   Average   Part of Publicly   Yet Be Purchased
    Shares   Price Paid   Announced Plans or   Under the Plans or
                  Period   Purchased   per Share   Programs   Programs
 
July 1, 2006 through July 31, 2006
                       
 
                               
August 1, 2006 through August 31, 2006
                       
 
                               
September 1, 2006 through September 30, 2006
    13,000,000     $ 8.00       13,000,000        
 
                               
 
Total
    13,000,000     $ 8.00       13,000,000        
 
On April 28, 2005, we announced a share buy-back program pursuant to which we had the right to purchase up to $50 million of our common shares over a two-year period. In December 2005 we increased the amount that could be purchased to $100 million worth of our common shares over a two-year period ending May 2007. The share purchases would be made as a normal course issuer bid. All purchases would be effected in the open market through the facilities of The Toronto Stock Exchange and the NASDAQ Stock Market, and in accordance with all regulatory requirements. The actual number of common shares which could be purchased and the timing of any such purchases were determined by management.
On July 27, 2006, we terminated the normal course issuer bid as a result of our decision to proceed with an offer to purchase up to 13 million shares in a modified “Dutch Auction” tender offer. The tender offer commenced on August 2, 2006 and expired on September 8, 2006. As a result of that tender offer, we accepted for purchase and cancellation 13 million common shares at a price of $8.00 per share, totalling $104 million.

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ITEM 3. DEFAULTS UPON SENIOR SECURITIES
     None.
ITEM 4. SUBMISSION OF MATTERS TO A VOTE OF SECURITY HOLDERS
     None.
ITEM 5. OTHER INFORMATION
     None.
ITEM 6. EXHIBITS
     
Exhibit    
Number   Description
 
31.1
  Certification pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 302 of the Sarbanes-Oxley Act of 2002: Robert L. Butchofsky, President and Chief Executive Officer;
 
   
31.2
  Certification pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 302 of the Sarbanes-Oxley Act of 2002: Cameron R. Nelson, Vice President, Finance and Chief Financial Officer;
 
   
32.1
  Certification pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002: Robert L. Butchofsky, President and Chief Executive Officer; and
 
   
32.2
  Certification pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002: Cameron R. Nelson, Vice President, Finance and Chief Financial Officer;

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SIGNATURES
Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned thereunto duly authorized.
             
 
      QLT Inc.    
 
      (Registrant)    
 
           
Date: November 9, 2006
  By:   /s/ Robert L. Butchofsky    
 
           
 
      Robert L. Butchofsky    
 
      President and Chief Executive Officer    
 
      (Principal Executive Officer)    
 
           
Date: November 9, 2006
  By:   /s/ Cameron R. Nelson    
 
           
 
      Cameron R. Nelson    
 
      Vice President, Finance and Chief Financial Officer    
 
      (Principal Financial and Accounting Officer)    

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EXHIBIT INDEX
     
Exhibit    
Number   Description
31.1
  Certification pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 302 of the Sarbanes-Oxley Act of 2002: Robert L. Butchofsky, President and Chief Executive Officer;
 
   
31.2
  Certification pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 302 of the Sarbanes-Oxley Act of 2002: Cameron R. Nelson, Vice President, Finance and Chief Financial Officer;
 
   
32.1
  Certification pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002: Robert L. Butchofsky, President and Chief Executive Officer; and
 
   
32.2
  Certification pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002: Cameron R. Nelson, Vice President, Finance and Chief Financial Officer;

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