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Shareholders' Equity (Tables)
 12 Months Ended
Dec. 31, 2016
Equity [Abstract]  
Summary of Stock Options Activity
The following table summarizes stock option activity for the Company during the three years ended December 31, 2016:
 
Options
 
Weighted
Average
Exercise
Price
 
Weighted
Average
Contractual
Term
 
Aggregate
Intrinsic
Value
Outstanding December 31, 2013
261,667

 
$
54.80

 
 
 
 
Granted
13,678

 
$
51.20

 
 
 
 
Exercised
(15,601
)
 
$
94.40

 
 
 
 
Forfeited or expired
(26,875
)
 
$
43.20

 
 
 
 
Outstanding December 31, 2014
232,869

 
$
53.20

 
 
 
 
Granted
46,075

 
$
21.60

 
 
 
 
Exercised
(1,250
)
 
$
10.80

 
 
 
 
Forfeited or expired
(9,697
)
 
$
70.40

 
 
 
 
Outstanding December 31, 2015
267,997

 
$
47.20

 
 
 
 

Granted
48,444

 
$
11.61

 
 
 
 

Exercised
—

 
$
—

 
 
 
 

Forfeited or expired
(153,776
)
 
$
40.63

 
 
 
 

Outstanding December 31, 2016
162,665

 
$
43.11

 
6.30
 
$
—

Vested or expected to vest at December 31, 2015
102,020

 


 

 
Summary of Carrying Value of Warrant Liability
The below table summarizes the warrant liability activity for the years ended December 31, 2016, 2015 and 2014. The gain included in net loss is reflective of several changes in the assumptions used in the computation of fair value, including the decrease in the Company's stock price, during the years ended December 31, 2016, 2015 and 2014.
 
2016
 
2015
 
2014
Beginning Balance, January 1
$
1,958,775

 
$
597,719

 
$
1,064,810

Issuance of warrants and effect of repricing
2,427,183

 
4,286,314

 
62,683

Exercise of warrants
—

 
—

 
—

(Gain) or loss included in earnings
(3,812,398
)
 
(2,925,258
)
 
(529,774
)
Transfers in and/or out of Level 3
—

 
—

 
—

Ending Balance December 31,
$
573,560

 
$
1,958,775

 
$
597,719