UNITED STATES
SECURITIES AND EXCHANGE COMMISSION

WASHINGTON, DC 20549

SCHEDULE 14A

(RULE 14A-101)

SCHEDULE 14A INFORMATION

PROXY STATEMENT PURSUANT TO SECTION 14(A) OF THE SECURITIES
EXCHANGE ACT OF 1934 (AMENDMENT NO. ___)

Filed by Registrant	þ
Filed by a Party other than the Registrant	o

Check the appropriate box:

o Preliminary Proxy Statement.

o Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)).

o Definitive Proxy Statement.

þ Definitive Additional Materials.

o Soliciting Material Pursuant to Section 240.14a-12.

FIRST AMERICAN INVESTMENT FUNDS, INC.

(Name of Registrant as Specified in its Charter)

(Name of Person(s) Filing Proxy Statement, if other than the Registrant)

Payment of Filing Fee (Check the appropriate box):

þ No fee required.

o Fee computed on table below per Exchange Act Rules 14a-6(i)(1) and 0-11.

(1) Title of each class of securities to which transaction applies:

(2) Aggregate number of securities to which transaction applies:

(3) Per unit price or other underlying value of transaction computed pursuant to Exchange Act Rule 0-11 (set forth the amount on which the filing fee is calculated and state how it was determined):

(4) Proposed maximum aggregate value of transaction:

(5) Total fee paid:

o Fee paid previously with preliminary materials.

o Check box if any part of the fee is offset as provided by Exchange Act Rule 0-11(a)(2) and identify the filing for which the offsetting fee was paid previously. Identify the previous filing by registration statement number, or the form or schedule and the date of its filing.

(1) Amount Previously Paid:

(2) Form, Schedule or Registration Statement No.:

(3) Filing Party:

(4) Date Filed:

December 3, 2010

URGENT-YOUR RESPONSE IS NEEDED
1-800-317-8033

“Address 1”
“Address 2”
“Address 3”
“Address 4”
“Address 5”
“Address 6”
“Address 7”

Re: First American Investment Funds

Dear Shareholder,

We have been trying to get in touch with you regarding an extremely important matter pertaining to your investment in one or more of the First American Investment Funds. This matter pertains to the advisory services performed by FAF Advisors, Inc. therefore it is extremely urgent that we speak to you.

FAF Advisors currently serves as investment advisor and administrator to each of the First American Investment Funds. On July 29, 2010, U.S. Bank and FAF Advisors entered into a definitive agreement with Nuveen Investments, Inc., Nuveen Asset Management and certain Nuveen affiliates, whereby Nuveen Asset Management will acquire a portion of the asset management business of FAF Advisors. The acquired business includes the assets of FAF Advisors used in providing investment advisory services to the First American Investment Funds. In this regard, each of the First American Investment Funds is asking shareholders to approve new investment advisory agreements with Nuveen Asset Management.

It is imperative that we hear from you on this matter. Please call 1-800-317-8033 (toll free) between 9:00 a.m. and 11:00 p.m. EST Monday to Friday and Saturday 12:00 p.m. to 6:00 p.m. We do not require you to provide any personal information when calling, and the call will only take a few minutes of your time.

Your prompt response is greatly appreciated. If you have already responded, thank you for your time.

Sincerely,

/s/ Thomas S. Schreier, Jr.

Thomas S. Schreier, Jr.
President