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Significant Contract, License and Royalty Agreements - Additional Information (Detail) - USD ($)
1 Months Ended 12 Months Ended
Dec. 31, 2015
Mar. 31, 2015
Jul. 31, 2011
Dec. 31, 2017
Dec. 31, 2016
Dec. 31, 2015
Dec. 31, 2013
Dec. 31, 2012
Apr. 30, 2015
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                  
Additional milestone payments related to active in-license agreements       $ 99,000,000          
Collaborative Arrangement [Member]                  
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                  
Revenue related to drug product delivered       0 $ 2,400,000 $ 6,000,000      
Recognized license revenue     $ 25,000,000 300,000 1,500,000 1,800,000      
Milestone payment upon finalization of the trial design               $ 10,000,000  
Revenue related to contract services delivered       12,900,000 10,100,000 8,700,000      
Collaborative Arrangement [Member] | Astellas In-License Agreements [Member]                  
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                  
Restricted stock issued, shares   86,121              
Potential future milestone payments   $ 99,000,000              
Collaborative Arrangement [Member] | Astellas In-License Agreements [Member] | Research and development [Member]                  
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                  
Cash payment for license agreement   $ 250,000              
IPPOX Foundation [Member]                  
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                  
Contractual obligation to manufacture HIV-antigen plasmid DNA                 $ 4,100,000
Revenue related to drug product delivered $ 4,100,000                
CytRx [Member]                  
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                  
License fees       $ 100,000 $ 100,000 $ 100,000      
CytRx [Member] | Up-front Payment [Member]                  
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                  
License fees             $ 3,800,000