-----BEGIN PRIVACY-ENHANCED MESSAGE-----
Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
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 TWSM7vrzLADbmYQaionwg5sDW3P6oaM5D3tdezXMm7z1T+B+twIDAQAB
MIC-Info: RSA-MD5,RSA,
 TnxsReb8xhCvD89UeEgWDYg13AFEPBZJERyn6W5k4HvxSnMGd4zDAzNmmdcg3XLE
 Uly2FHnwJSqFuMyhFaDHUQ==

<SEC-DOCUMENT>0001209191-09-025706.txt : 20090511
<SEC-HEADER>0001209191-09-025706.hdr.sgml : 20090511
<ACCEPTANCE-DATETIME>20090511161500
ACCESSION NUMBER:		0001209191-09-025706
CONFORMED SUBMISSION TYPE:	4
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20090507
FILED AS OF DATE:		20090511
DATE AS OF CHANGE:		20090511

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			VICAL INC
		CENTRAL INDEX KEY:			0000819050
		STANDARD INDUSTRIAL CLASSIFICATION:	BIOLOGICAL PRODUCTS (NO DIAGNOSTIC SUBSTANCES) [2836]
		IRS NUMBER:				930948554
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		10390 PACIFIC CENTER COURT
		STREET 2:		.
		CITY:			SAN DIEGO
		STATE:			CA
		ZIP:			92121-4340
		BUSINESS PHONE:		858-646-1100

	MAIL ADDRESS:	
		STREET 1:		10390 PACIFIC CENTER COURT
		STREET 2:		.
		CITY:			SAN DIEGO
		STATE:			CA
		ZIP:			92121-4340

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			TEMASEK HOLDINGS (PRIVATE) LTD
		CENTRAL INDEX KEY:			0001021944
		FISCAL YEAR END:			0331

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-21088
		FILM NUMBER:		09815154

	BUSINESS ADDRESS:	
		STREET 1:		60B ORCHARD ROAD #06-18 TOWER 2
		STREET 2:		THE ATRIUM @ ORCHARD
		CITY:			SINGAPORE
		STATE:			U0
		ZIP:			238891
		BUSINESS PHONE:		(65) 6828 6828

	MAIL ADDRESS:	
		STREET 1:		60B ORCHARD ROAD #06-18 TOWER 2
		STREET 2:		THE ATRIUM @ ORCHARD
		CITY:			SINGAPORE
		STATE:			U0
		ZIP:			238891

	FORMER NAME:	
		FORMER CONFORMED NAME:	TEMASEK HOLDINGS LTD
		DATE OF NAME CHANGE:	19960829

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Fullerton Management Pte Ltd
		CENTRAL INDEX KEY:			0001379348
		STATE OF INCORPORATION:			U0
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-21088
		FILM NUMBER:		09815155

	BUSINESS ADDRESS:	
		STREET 1:		60B ORCHARD ROAD, #06-18 TOWER 2
		STREET 2:		THE ATRIUM@ORCHARD
		CITY:			SINGAPORE
		STATE:			U0
		ZIP:			238891
		BUSINESS PHONE:		0116568286762

	MAIL ADDRESS:	
		STREET 1:		60B ORCHARD ROAD, #06-18 TOWER 2
		STREET 2:		THE ATRIUM@ORCHARD
		CITY:			SINGAPORE
		STATE:			U0
		ZIP:			238891

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Temasek Life Sciences Private LTD
		CENTRAL INDEX KEY:			0001379349
		STATE OF INCORPORATION:			U0
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-21088
		FILM NUMBER:		09815156

	BUSINESS ADDRESS:	
		STREET 1:		60B ORCHARD ROAD, #06-18 TOWER 2
		STREET 2:		THE ATRIUM@ORCHARD
		CITY:			SINGAPORE
		STATE:			U0
		ZIP:			238891
		BUSINESS PHONE:		0116568286762

	MAIL ADDRESS:	
		STREET 1:		60B ORCHARD ROAD, #06-18 TOWER 2
		STREET 2:		THE ATRIUM@ORCHARD
		CITY:			SINGAPORE
		STATE:			U0
		ZIP:			238891

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			V-Sciences Investments Pte Ltd
		CENTRAL INDEX KEY:			0001379350

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-21088
		FILM NUMBER:		09815157

	BUSINESS ADDRESS:	
		STREET 1:		60B ORCHARD ROAD, #06-18 TOWER 2
		STREET 2:		THE ATRIUM@ORCHARD
		CITY:			SINGAPORE
		STATE:			U0
		ZIP:			238891
		BUSINESS PHONE:		0116568286762

	MAIL ADDRESS:	
		STREET 1:		60B ORCHARD ROAD, #06-18 TOWER 2
		STREET 2:		THE ATRIUM@ORCHARD
		CITY:			SINGAPORE
		STATE:			U0
		ZIP:			238891
</SEC-HEADER>
<DOCUMENT>
<TYPE>4
<SEQUENCE>1
<FILENAME>c85238_4x0.xml
<DESCRIPTION>MAIN DOCUMENT DESCRIPTION
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0303</schemaVersion>

    <documentType>4</documentType>

    <periodOfReport>2009-05-07</periodOfReport>

    <issuer>
        <issuerCik>0000819050</issuerCik>
        <issuerName>VICAL INC</issuerName>
        <issuerTradingSymbol>VICL</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001379350</rptOwnerCik>
            <rptOwnerName>V-Sciences Investments Pte Ltd</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>60B ORCHARD ROAD #06-18, TOWER 2</rptOwnerStreet1>
            <rptOwnerStreet2>THE ATRIUM@ORCHARD</rptOwnerStreet2>
            <rptOwnerCity>SINGAPORE</rptOwnerCity>
            <rptOwnerState>U0</rptOwnerState>
            <rptOwnerZipCode>238891</rptOwnerZipCode>
            <rptOwnerStateDescription>SINGAPORE</rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001379349</rptOwnerCik>
            <rptOwnerName>Temasek Life Sciences Private LTD</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>60B ORCHARD ROAD #06-18, TOWER 2</rptOwnerStreet1>
            <rptOwnerStreet2>THE ATRIUM@ORCHARD</rptOwnerStreet2>
            <rptOwnerCity>SINGAPORE</rptOwnerCity>
            <rptOwnerState>U0</rptOwnerState>
            <rptOwnerZipCode>238891</rptOwnerZipCode>
            <rptOwnerStateDescription>SINGAPORE</rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001379348</rptOwnerCik>
            <rptOwnerName>Fullerton Management Pte Ltd</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>60B ORCHARD ROAD #06-18, TOWER 2</rptOwnerStreet1>
            <rptOwnerStreet2>THE ATRIUM@ORCHARD</rptOwnerStreet2>
            <rptOwnerCity>SINGAPORE</rptOwnerCity>
            <rptOwnerState>U0</rptOwnerState>
            <rptOwnerZipCode>238891</rptOwnerZipCode>
            <rptOwnerStateDescription>SINGAPORE</rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001021944</rptOwnerCik>
            <rptOwnerName>TEMASEK HOLDINGS (PRIVATE) LTD</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>60B ORCHARD ROAD #06-18, TOWER 2</rptOwnerStreet1>
            <rptOwnerStreet2>THE ATRIUM@ORCHARD</rptOwnerStreet2>
            <rptOwnerCity>SINGAPORE</rptOwnerCity>
            <rptOwnerState>U0</rptOwnerState>
            <rptOwnerZipCode>238891</rptOwnerZipCode>
            <rptOwnerStateDescription>SINGAPORE</rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Common Shares</value>
            </securityTitle>
            <transactionDate>
                <value>2009-05-07</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>S</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>205260.000</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>2.3626</value>
                    <footnoteId id="F1"/>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>D</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>4452409.0000</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                    <footnoteId id="F2"/>
                </directOrIndirectOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Common Shares</value>
            </securityTitle>
            <transactionDate>
                <value>2009-05-08</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>S</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>129600.0000</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>2.3842</value>
                    <footnoteId id="F3"/>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>D</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>4322809.0000</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                    <footnoteId id="F2"/>
                </directOrIndirectOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
    </nonDerivativeTable>

    <derivativeTable></derivativeTable>

    <footnotes>
        <footnote id="F1">Represents the weighted average price of 636 different transactions. Actual sale prices ranged from $2.17 to $2.60 per share. The reporting person will provide to the issuer, any shareholder of the issuer, or the staff of the Securities and Exchange Commission (the &quot;Staff&quot;), upon request, information regarding the number of shares of common stock, $0.01 par value per share, which are the subject of this filing (the &quot;Shares&quot;), sold at each price within the range.</footnote>
        <footnote id="F2">Temasek Holdings (Private) Limited, is the parent of Fullerton Management Pte Ltd, which is the parent of Temasek Life Sciences Private Limited, which is the parent of V-Sciences Investments Pte Ltd (the designated filer), which directly owns the Shares. Because of the foregoing relationships, the direct and indirect parents of V-Sciences Investments Pte Ltd may be deemed to beneficially own the Shares.</footnote>
        <footnote id="F3">Represents the weighted average price of 431 different transactions. Actual sale prices ranged from $2.32 to $2.57 per share. The reporting person will provide to the issuer, any shareholder of the issuer, or the Staff, upon request, information regarding the number of Shares sold at each price within the range.</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>/s/ Chong Kwang Cheong Robert, Director, V-Sciences Investments Pte Ltd</signatureName>
        <signatureDate>2009-05-11</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>/s/ Cheo Hock Kuan, Director, Temasek Life Sciences Private Limited</signatureName>
        <signatureDate>2009-05-11</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>/s/ Lena Chia Yue Joo, Director, Fullerton Management Pte Ltd</signatureName>
        <signatureDate>2009-05-11</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>/s/ Lena Chia Yue Joo, Managing Director, Legal &amp; Regulations, Temasek Holdings (Private) Limited</signatureName>
        <signatureDate>2009-05-11</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
-----END PRIVACY-ENHANCED MESSAGE-----