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Consolidated Statements of Stockholders' Equity - USD ($)
$ in Thousands
Common Stock [Member]
Additional Paid-in Capital [Member]
AOCI Attributable to Parent [Member]
Retained Earnings [Member]
Total
Balance (in shares) at Dec. 31, 2015 36,106,000        
Balance at Dec. 31, 2015 $ 361 $ 530,617 $ (40) $ (412,828) $ 118,110
Conversion benefit included in Convertible Notes issued 348 348
Issuance of common stock under Employee Stock Purchase Plan (in shares) 55,000        
Issuance of common stock under Employee Stock Purchase Plan $ 1 770 $ 771
Issuance of common stock on exercise of stock options (in shares) 798,000       798,363
Issuance of common stock on exercise of stock options $ 8 6,676 $ 6,684
Issuance of common stock on exercise of warrants (in shares) 2,396,000        
Issuance of common stock on exercise of warrants $ 24 (24)
Stock-based compensation expense 25,956 25,956
Net loss (173,143) (173,143)
Net unrealized gain on short-term investments 23 23
Comprehensive loss (173,120)
Balance (in shares) at Dec. 31, 2016 39,355,000        
Balance at Dec. 31, 2016 $ 394 564,343 (17) (585,971) (21,251)
Conversion benefit included in Convertible Notes issued 369 369
Issuance of common stock under Employee Stock Purchase Plan (in shares) 77,000        
Issuance of common stock under Employee Stock Purchase Plan $ 1 988 $ 989
Issuance of common stock on exercise of stock options (in shares) 1,351,000       1,350,605
Issuance of common stock on exercise of stock options $ 13 11,450 $ 11,463
Issuance of common stock on exercise of warrants (in shares) 4,000        
Issuance of common stock on exercise of warrants
Stock-based compensation expense 30,538 30,538
Net loss (197,484) (197,484)
Net unrealized gain on short-term investments 7 7
Comprehensive loss (197,477)
Issuance of common stock in public offerings, net (in shares) 23,822,000        
Issuance of common stock in public offerings, net $ 238 306,041 306,279
Issuance of warrants 226 226
Balance (in shares) at Dec. 31, 2017 64,609,000        
Balance at Dec. 31, 2017 $ 646 913,955 (10) (783,455) 131,136
Conversion benefit included in Convertible Notes issued 392 392
Issuance of common stock under Employee Stock Purchase Plan (in shares) 72,000        
Issuance of common stock under Employee Stock Purchase Plan $ 1 1,178 $ 1,179
Issuance of common stock on exercise of stock options (in shares) 1,530,000       1,529,509
Issuance of common stock on exercise of stock options $ 15 18,286 $ 18,301
Stock-based compensation expense 33,367 33,367
Net loss (178,840) (178,840)
Net unrealized gain on short-term investments (77) (77)
Comprehensive loss (178,917)
Issuance of common stock in public offerings, net (in shares) 11,963,000        
Issuance of common stock in public offerings, net $ 120 363,008 363,128
Balance (in shares) at Dec. 31, 2018 78,174,000        
Balance at Dec. 31, 2018 $ 782 1,330,186 (87) (960,721) 370,160
Cumulative Effect of New Accounting Principle in Period of Adoption $ 1,574 $ 1,574