Note 11 - Summary of Quarterly Consolidated Financial Data (Unaudited) - Summary Quarterly Results of Operations (Details) - USD ($) |
3 Months Ended | 12 Months Ended | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Dec. 31, 2016 |
Sep. 30, 2016 |
Jun. 30, 2016 |
Mar. 31, 2016 |
Dec. 31, 2015 |
Sep. 30, 2015 |
Jun. 30, 2015 |
Mar. 31, 2015 |
Dec. 31, 2016 |
Dec. 31, 2015 |
Dec. 31, 2014 |
|
Revenues: | |||||||||||
Net product sales | $ 1,279,000 | $ 1,279,000 | |||||||||
Operating expenses: | |||||||||||
Cost of Goods Sold | 35,000 | 35,000 | |||||||||
Research and development | 29,505,000 | 30,242,000 | 27,286,000 | 16,092,000 | $ 16,263,000 | $ 14,241,000 | $ 16,175,000 | $ 14,504,000 | 103,125,000 | 61,183,000 | 54,833,000 |
General and administrative | 5,892,000 | 5,333,000 | 4,774,000 | 5,367,000 | 6,599,000 | 4,127,000 | 4,082,000 | 3,587,000 | 21,366,000 | 18,395,000 | 11,020,000 |
Sales and marketing | 12,650,000 | 12,159,000 | 11,006,000 | 11,853,000 | 8,198,000 | 4,123,000 | 2,757,000 | 2,269,000 | 47,668,000 | 17,347,000 | 8,708,000 |
Loss from operations | (46,803,000) | (47,734,000) | (43,066,000) | (33,312,000) | (31,060,000) | (22,491,000) | (23,014,000) | (20,360,000) | |||
Interest income | 119,000 | 111,000 | 97,000 | 118,000 | 65,000 | 61,000 | 26,000 | 22,000 | |||
Interest expense | (1,270,000) | (886,000) | (257,000) | (251,000) | (247,000) | (242,000) | (237,000) | (232,000) | (2,664,000) | (958,000) | (887,000) |
Other expense | (9,000) | 118,000 | 436,000 | 292,000 | (919,000) | ||||||
Net loss | $ (47,963,000) | $ (48,509,000) | $ (43,226,000) | $ (33,445,000) | $ (31,242,000) | $ (22,672,000) | $ (23,107,000) | $ (20,570,000) | $ (173,143,000) | $ (97,591,000) | $ (76,367,000) |
Basic and diluted net loss per share (in dollars per share) | $ (1.22) | $ (1.24) | $ (1.17) | $ (0.92) | $ (0.87) | $ (0.63) | $ (0.74) | $ (0.70) | $ (4.56) | $ (2.95) | $ (2.87) |