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Note 11 - Summary of Quarterly Consolidated Financial Data (Unaudited) - Summary Quarterly Results of Operations (Details) - USD ($)
3 Months Ended 12 Months Ended
Dec. 31, 2016
Sep. 30, 2016
Jun. 30, 2016
Mar. 31, 2016
Dec. 31, 2015
Sep. 30, 2015
Jun. 30, 2015
Mar. 31, 2015
Dec. 31, 2016
Dec. 31, 2015
Dec. 31, 2014
Revenues:                      
Net product sales $ 1,279,000         $ 1,279,000
Operating expenses:                      
Cost of Goods Sold 35,000         35,000
Research and development 29,505,000 30,242,000 27,286,000 16,092,000 $ 16,263,000 $ 14,241,000 $ 16,175,000 $ 14,504,000 103,125,000 61,183,000 54,833,000
General and administrative 5,892,000 5,333,000 4,774,000 5,367,000 6,599,000 4,127,000 4,082,000 3,587,000 21,366,000 18,395,000 11,020,000
Sales and marketing 12,650,000 12,159,000 11,006,000 11,853,000 8,198,000 4,123,000 2,757,000 2,269,000 47,668,000 17,347,000 8,708,000
Loss from operations (46,803,000) (47,734,000) (43,066,000) (33,312,000) (31,060,000) (22,491,000) (23,014,000) (20,360,000)      
Interest income 119,000 111,000 97,000 118,000 65,000 61,000 26,000 22,000      
Interest expense (1,270,000) (886,000) (257,000) (251,000) (247,000) (242,000) (237,000) (232,000) (2,664,000) (958,000) (887,000)
Other expense (9,000) 118,000 436,000 292,000 (919,000)
Net loss $ (47,963,000) $ (48,509,000) $ (43,226,000) $ (33,445,000) $ (31,242,000) $ (22,672,000) $ (23,107,000) $ (20,570,000) $ (173,143,000) $ (97,591,000) $ (76,367,000)
Basic and diluted net loss per share (in dollars per share) $ (1.22) $ (1.24) $ (1.17) $ (0.92) $ (0.87) $ (0.63) $ (0.74) $ (0.70) $ (4.56) $ (2.95) $ (2.87)