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Consolidated Statements of Stockholders' (Deficit) Equity - USD ($)
shares in Thousands, $ in Thousands
Total
Private Placement
Common Stock
Common Stock
Private Placement
Additional Paid-In Capital
Additional Paid-In Capital
Private Placement
Accumulated Other Comprehensive Income (Loss)
Accumulated Deficit
Balance at Dec. 31, 2021 $ 77,570   $ 1,020   $ 1,689,987   $ (6) $ (1,613,431)
Balance (in shares) at Dec. 31, 2021     102,005          
Issuance of common stock under Employee Stock Purchase Plan 1,444   $ 4   1,440      
Issuance of common stock under Employee Stock Purchase Plan (in shares)     407          
Issuance of common stock under equity incentive plan (1,530)   $ 6   (1,536)      
Issuance of common stock under equity incentive plan (in shares)     614          
Issuance of common stock in a private placement   $ 75,145   $ 161   $ 74,984    
Issuance of common stock in a private placement (in shares)       16,129        
Stock-based compensation expense 42,980       42,980      
Net loss (182,024)             (182,024)
Net unrealized gain (loss) on short-term investments (13)           (13)  
Comprehensive loss (182,037)              
Balance at Dec. 31, 2022 13,572   $ 1,191   1,807,855   (19) (1,795,455)
Balance (in shares) at Dec. 31, 2022     119,155          
Issuance of common stock under Employee Stock Purchase Plan 904   $ 7   897      
Issuance of common stock under Employee Stock Purchase Plan (in shares)     717          
Issuance of common stock under equity incentive plan (903)   $ 11   (914)      
Issuance of common stock under equity incentive plan (in shares)     1,130          
Issuance of common stock in a private placement   $ 29,755   $ 208   $ 29,547    
Issuance of common stock in a private placement (in shares)       20,735        
Issuance of common stock on exercise of pre-funded warrants 1   $ 86   (85)      
Issuance of common stock on exercise of pre-funded warrants (in shares)     8,548          
Issuance of warrants in debt financing 371       371      
Stock-based compensation expense 32,854       32,854      
Net loss (110,559)             (110,559)
Net unrealized gain (loss) on short-term investments 32           32  
Comprehensive loss (110,527)              
Balance at Dec. 31, 2023 $ (33,973)   $ 1,503   $ 1,870,525   $ 13 $ (1,906,014)
Balance (in shares) at Dec. 31, 2023     150,285