EXHIBIT 32.1

        CERTIFICATION PURSUANT TO SECTION 1350 OF CHAPTER 63 OF 18 U.S.C.
  AS ADOPTED PURSUANT TO SECTION 906 OF THE SARBANES-OXLEY ACT OF 2002/SEC RULE
                                   13a-14(b)

In connection with the Quarterly Report of The Immune Response Corporation (the
"Company") on Form 10-Q for the period ending March 31, 2005 as filed with the
Securities and Exchange Commission (the "Report"), which this written statement
accompanies, I, John N. Bonfiglio, Chief Executive Officer of the Company,
certify that:

      (1)   The Report fully complies with the requirements of section 13(a) of
            the Securities Exchange Act of 1934; and

      (2)   The information contained in the Report fairly presents, in all
            material respects, the financial condition and results of operations
            of the Company.

Dated: May 13, 2005                                    /s/ John N. Bonfiglio
                                                       ------------------------
                                                       John N. Bonfiglio
                                                       Chief Executive Officer