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Stockholders' Equity - Summary of Anti-Dilutive Options Excluded (Details) - $ / shares
3 Months Ended 6 Months Ended
Jun. 30, 2017
Jun. 30, 2016
Jun. 30, 2017
Jun. 30, 2016
Stockholders' Equity Note [Abstract]        
Options to purchase shares of common stock (in shares) 3,897,177 3,253,343 3,603,850 2,941,864
Weighted average exercise price of options (in dollars per share) $ 49.18 $ 49.91 $ 49.81 $ 50.39