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Consolidated Statements of Cash Flows - USD ($)
12 Months Ended
Dec. 31, 2023
Dec. 31, 2022
Operating activities:    
Net loss $ (6,140,730) $ (13,798,339)
Adjustments to reconcile net loss to net cash used in operating activities:    
Amortization and depreciation 6,554 24,562
Non-cash lease expense 111,153 112,714
Share-based compensation 370,182 333,389
Issuance of common stock to vendors for services 73,000 212,003
Issuance of common stock for unexercised purchase option 50,000  
Loss on extinguishment of debt 393,791  
Change in fair value of convertible debt (43,066)  
Amortization of deferred issuance costs associated with convertible debt 12,518 41,538
Change in operating assets and liabilities:    
Licensing, contracts and grants receivable (56,124) 23,759
Prepaid expenses and other current assets (591,805) 8,694
Research and development incentives receivable 90,016 73,374
Operating lease liability (108,948) (111,122)
Accounts payable and accrued expenses (2,685,073) 396,651
Accrued compensation (85,577) 33,756
Net cash used in operating activities (8,604,109) (12,649,021)
Investing activities:    
Purchases of office furniture and equipment   (13,073)
Net cash used in investing activities   (13,073)
Financing activities:    
Proceeds from issuance of common stock pursuant to B. Riley At Market Issuance Sales Agreement 3,091,462 79,354
Proceeds from issuance of common stock and pre-funded warrants pursuant to public offering 8,495,817  
Convertible debt repayments (7,000,000)  
Net cash provided by financing activities 3,663,506 76,821
Effect of exchange rate on cash and cash equivalents 27,146 (99,009)
Net decrease in cash and cash equivalents (4,913,457) (12,684,282)
Cash and cash equivalents at beginning of year 13,359,615 26,043,897
Cash and cash equivalents at end of year 8,446,158 13,359,615
Supplemental information:    
Cash paid for state income taxes 20,730 16,043
Cash paid for interest 552,058 857,411
Cash paid for lease liabilities:    
Operating lease 133,817 133,300
Non-cash investing and financing activities:    
Right-of-use assets and lease liabilities recorded   347,546
Deferred issuance cost reclassified to additional paid-in capital 20,208 60
Declaration of Series D preferred stock for stock dividend   43
Redemption of Series D preferred stock for stock dividend 43  
B. Riley Sales Agreement    
Financing activities:    
Stock issuance costs associated (93,011) $ (2,533)
Public Offering    
Financing activities:    
Stock issuance costs associated (834,061)  
Pre-funded warrants    
Financing activities:    
Proceeds from the exercise of pre-funded warrants $ 3,299